Cited by 122Antimicrobial Peptides and ActivitiesHerpesvirus Infections and TreatmentsAntimicrobial agents and applications

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1

Open access

Torres, Nicolás I., Noll, Katia Sutyak, Xu, Shiqi, Li, Ji, Huang, Qingrong, Sinko, Patrick J., Wachsman, Mónica B., Chikindas, Michael L.·2013·Probiotics and Antimicrobial Proteins

DOI 10.1007/s12602-012-9123-xPMC PMC3637976

Open this paper in CoChat — free account

Abstract

In the present study the antiviral properties of the bacteriocin subtilosin against Herpes simplex virus type 1 (HSV-1) and the safety and efficacy of a subtilosin-based nanofiber formulation were determined. High concentrations of subtilosin, the cyclical antimicrobial peptide produced by Bacillus amyloliquefaciens, were virucidal against HSV-1. Interestingly, at non-virucidal concentrations, subtilosin inhibited wild type HSV-1 and aciclovir-resistant mutants in a dose-dependent manner. Although the exact antiviral mechanism is not fully understood, time of addition experiments and western blot analysis suggest that subtilosin does not affect viral multiplication steps prior to protein synthesis. Poly(vinyl alcohol) (PVOH)-based subtilosin nanofibers with a width of 278 nm were produced by the electrospinning process. The retained antimicrobial activity of the subtilosin-based fibers was determined via an agar well diffusion assay. The loading capacity of the fibers was 2.4 mg subtilosin/g fiber, and loading efficiency was 31.6%. Furthermore, the nanofibers with and without incorporated subtilosin were shown to be nontoxic to human epidermal tissues using an in vitro human tissue model. Taking together these results subtilosin-based nanofibers should be further studied as a novel alternative method for treatment and/or control of HSV-1 infection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s12602-012-9123-x

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Rapid colorimetric assay for cell growth and survival
Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,935
Peptide Antimicrobial Agents
Jenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,605
Herpes simplex virus infections
Whitley, R. J., & Roizman, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04638-9 · Cited by 1,391
Taylor cone and jetting from liquid droplets in electrospinning of nanofibers
Yarin, A. L., Koombhongse, S., & Reneker, D. H. (2001) · Journal of Applied Physics · doi:10.1063/1.1408260 · Cited by 895
Electrospinning: A whipping fluid jet generates submicron polymer fibers
Shin, Y.-S., Hohman, M. M., Brenner, M. P., & Rutledge, G. C. (2001) · Applied Physics Letters · doi:10.1063/1.1345798 · Cited by 702
Diversity and applications of Bacillus bacteriocins
Abriouel, H., Franz, C. M. A. P., Benomar, N., & Gálvez, A. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00244.x · Cited by 633
Genital herpes
Gupta, R., Warren, T. J., & Wald, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61908-4 · Cited by 595
The neurotropic herpes viruses: herpes simplex and varicella-zoster
Steiner, I., Kennedy, P. G. E., & Pachner, A. R. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70267-3 · Cited by 572
Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management
Fatahzadeh, M., & Schwartz, R. A. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.06.027 · Cited by 571
Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management
Piret, J., & Boivin, G. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00615-10 · Cited by 558

Show all 55 references

Sorted by citations

Bacteriocins, Antimicrobial Peptides from Bacterial Origin: Overview of Their Biology and Their Impact against Multidrug-Resistant Bacteria
Simons, A., Alhanout, K., & Duval, R. E. (2020) · Microorganisms · doi:10.3390/microorganisms8050639 · Cited by 587
Antimicrobial Peptides as Potential Alternatives to Antibiotics in Food Animal Industry
Wang, S., Zeng, X., Yang, Q., & Qiao, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050603 · Cited by 431
Antimicrobial peptides of the genus Bacillus : a new era for antibiotics
Sumi, C. D., Yang, B. W., Yeo, I., & Hahm, Y. T. (2014) · Canadian Journal of Microbiology · doi:10.1139/cjm-2014-0613 · Cited by 379
Gut microbiota as a source of novel antimicrobials
García-Gutiérrez, E., Mayer, M. J., Cotter, P. D., & Narbad, A. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1455790 · Cited by 306
Antimicrobial potential of bacteriocins: in therapy, agriculture and food preservation
Ahmad, V., Khan, M. S., Jamal, Q. M. S., Alzohairy, M. A., Karaawi, M. A. A., & Siddiqui, M. U. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.08.016 · Cited by 292
Bacteriocin diversity, function, discovery and application as antimicrobials
Sugrue, I., Ross, R. P., & Hill, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01045-x · Cited by 286
Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine
Hernández-González, J. C., Martínez-Tapia, A., Lazcano-Hernández, G., García‐Pérez, B. E., & Castrejón-Jiménez, N. S. (2021) · Animals · doi:10.3390/ani11040979 · Cited by 278
Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins
Al Kassaa, I., Hober, D., Hamze, M., Chihib, N. E., & Drider, D. (2014) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-014-9162-6 · Cited by 217
Antimicrobial peptides: an alternative for innovative medicines?
da Costa, J. P., Cova, M. M., Ferreira, R. M., & Vitorino, R. M. P. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6375-x · Cited by 212
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177
Antimicrobial potential of bacteriocins in poultry and swine production
Lagha, A. B., Haas, B., Gottschalk, M. G., & Grenier, D. (2017) · Veterinary Research · doi:10.1186/s13567-017-0425-6 · Cited by 209
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides
Ongpipattanakul, C., Desormeaux, E. K., DiCaprio, A. J., van der Donk, W. A., Mitchell, D. A., & Nair, S. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00210 · Cited by 169
Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice
Heunis, T. D. J., Smith, C., & Dicks, L. M. T. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00622-13 · Cited by 157
Subtilosin Prevents Biofilm Formation by Inhibiting Bacterial Quorum Sensing
Algburi, A., Zehm, S., Netrebov, V., Bren, A. B., Chistyakov, V. A., & Chikindas, M. L. (2016) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-016-9242-x · Cited by 128
Prebiotic, Probiotic, Antimicrobial, and Functional Food Applications of Bacillus amyloliquefaciens
Woldemariam, K. Y., Wan, Z., Yu, Q., Li, H., Wei, X., Liu, Y., Wang, J., & Sun, B. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06396 · Cited by 128
Use of Bacteriocins and Bacteriocinogenic Beneficial Organisms in Food Products: Benefits, Challenges, Concerns
Todorov, S. D., Popov, I. V., Weeks, R. M., & Chikindas, M. L. (2022) · Foods · doi:10.3390/foods11193145 · Cited by 134
Bacteriocins of lactic acid bacteria as biotechnological tools in food and pharmaceuticals: Current applications and future prospects
Daba, G. M., & Elkhateeb, W. A. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101750 · Cited by 117
Probiotics at War Against Viruses: What Is Missing From the Picture?
Tiwari, S. K., Dicks, L. M. T., Popov, I. V., Karaseva, A. B., Ermakov, A. M., Suvorov, A. N., Tagg, J. R., Weeks, R. M., & Chikindas, M. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01877 · Cited by 109
Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate
Jabeen, S., Islam, A., Ghaffar, A., Gull, N., Hameed, A., Bashir, A., Jamil, T., & Hussain, T. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.014 · Cited by 98
The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis
Fakharian, F., Thirugnanam, S., Welsh, D. A., Kim, W., Rappaport, J., Bittinger, K. L., & Rout, N. (2023) · Microorganisms · doi:10.3390/microorganisms11071849 · Cited by 107
Fabrication of novel carrageenan based stimuli responsive injectable hydrogels for controlled release of cephradine
Rasool, A., Ata, S., Islam, A., & Khan, R. U. (2019) · RSC Advances · doi:10.1039/c9ra02130b · Cited by 90
A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis
Gopinath, D., Koe, K. H., Maharajan, M. K., & Panda, S. (2023) · Viruses · doi:10.3390/v15010225 · Cited by 98
Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications
Dart, A., Bhave, M. R., & Kingshott, P. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201800488 · Cited by 87
On Bacteriocin Delivery Systems and Potential Applications
Arthur, T. D., Cavera, V. L., & Chikindas, M. L. (2014) · Future Microbiology · doi:10.2217/fmb.13.148 · Cited by 85
Bacillales: From Taxonomy to Biotechnological and Industrial Perspectives
Harirchi, S., Şar, T., Ramezani, M., Aliyu, H., Etemadifar, Z., Nojoumi, S. A., Yazdian, F. A., Awasthi, M. K., & Taherzadeh, M. J. (2022) · Microorganisms · doi:10.3390/microorganisms10122355 · Cited by 85
Anti-influenza Activity of a Bacillus subtilis Probiotic Strain
Starosila, D., Рыбалко, С. Л., Varbanetz, L., Ivanskaya, N. V., & Sorokulova, I. B. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00539-17 · Cited by 82
Nanostructures for delivery of natural antimicrobials in food
Lopes, N. A., & Brandelli, A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1308915 · Cited by 82
Self-crosslinked chitosan/κ-carrageenan-based biomimetic membranes to combat diabetic burn wound infections
Khaliq, T., Sohail, M. F., Minhas, M. U., Shah, S. A., Jabeen, N., Khan, S., Hussain, Z., Mahmood, A., Kousar, M., & Rashid, H. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.100 · Cited by 87
Antimicrobial Effect of Probiotics against Common Pathogens
Fijan, S. (2016) · InTech eBooks · doi:10.5772/63141 · Cited by 76
Bacteriocins: potentials and prospects in health and agrifood systems
Reuben, R. C., & Torres, C. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03948-y · Cited by 88
Antimicrobial Nanomaterials Derived from Natural Products—A Review
Wang, J., & Vermerris, W. (2016) · Materials · doi:10.3390/ma9040255 · Cited by 75
Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin
Quintana, V. M., Torres, N. I., Wachsman, M. B., Sinko, P. J., Castilla, V., & Chikindas, M. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12618 · Cited by 69
In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP 4 protein production
Olaya-Galán, N. N., Ulloa, J. C., Reyes, F. A. V., Duarte, K. P. F., Salas-Cárdenas, S. P., & Fernández, M. F. G. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13069 · Cited by 68
Bacteriocinogenic LAB Strains for Fermented Meat Preservation: Perspectives, Challenges, and Limitations
Favaro, L., & Todorov, S. D. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9330-6 · Cited by 73
Nanofibers as drug-delivery systems for antimicrobial peptides
Sousa, M. G. C., Rezende, T. M. B., & Franco, O. L. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.03.008 · Cited by 65
Development of Pleurocidin-poly(vinyl alcohol) electrospun antimicrobial nanofibers to retain antimicrobial activity in food system application
Wang, X., Yue, T., & Lee, T.-C. (2015) · Food Control · doi:10.1016/j.foodcont.2015.02.001 · Cited by 61
Endophytic bacteria from banana cultivars and their antifungal activity
de SOUZA, Á., da Cruz, J. C., Sousa, N. R. G., Procópio, A. R. L., & Silva, G. F. (2014) · Genetics and Molecular Research · doi:10.4238/2014.october.27.6 · Cited by 59
Postbiotics as the key mediators of the gut microbiota-host interactions
Ozma, M. A., Abbasi, A., Akrami, S., Lahouty, M., Shahbazi, N., Ganbarov, K., Pagliano, P., Sabahi, S., Köse, Ş., Yousefi, M., et al. (2022) · Infezioni in Medicina · doi:10.53854/liim-3002-3 · Cited by 61
Microbial Biopesticides: Diversity, Scope, and Mechanisms Involved in Plant Disease Control
Vero, S., Garmendia, G., Allori, E., Sanz‐Martín, J. M., Gonda, M., Alconada, T. M., Cavello, I., Dib, J. R., Díaz, M. A., Nally, M. C., et al. (2023) · Diversity · doi:10.3390/d15030457 · Cited by 57
Potential Novel Food-Related and Biomedical Applications of Nanomaterials Combined with Bacteriocins
Naskar, A., & Kim, K.-S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010086 · Cited by 57
Antiviral Active Compounds Derived from Natural Sources against Herpes Simplex Viruses
van de Sand, L., Bormann, M., Schmitz, Y., Heilingloh, C. S., Witzke, O., & Krawczyk, A. (2021) · Viruses · doi:10.3390/v13071386 · Cited by 55
Bacteriocin nanoconjugates: boon to medical and food industry
Sulthana, R., & Archer, A. C. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14982 · Cited by 55
Controlled release of protein from core–shell nanofibers prepared by emulsion electrospinning based on green chemical
Wang, X., Yuan, Y., Huang, X., & Yue, T. (2014) · Journal of Applied Polymer Science · doi:10.1002/app.41811 · Cited by 51
The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health
Ismael, M., Huang, M., & Zhong, Q. (2024) · Foods · doi:10.3390/foods13233887 · Cited by 57
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)
Fu, Y., Jaarsma, A. H., & Kuipers, O. P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03759-0 · Cited by 48
The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
Wu, D., Fu, L., Wen, W., & Dong, N. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00796-y · Cited by 48
Bacteriocin encapsulation for food and pharmaceutical applications: advances in the past 20 years
Chandrakasan, G., Rodríguez‐Hernández, A., López-Cuellar, M. D. R., Palma‐Rodríguez, H. M., & Chavarría‐Hernández, N. (2019) · Biotechnology Letters · doi:10.1007/s10529-018-02635-5 · Cited by 47
Anti–Influenza Activity of Enterocin B In vitro and Protective Effect of Bacteriocinogenic Enterococcal Probiotic Strain on Influenza Infection in Mouse Model
Ермоленко, Е. И., Desheva, Y. A., Kolobov, A. A., Котылева, М. П., Sychev, I. А., & Suvorov, A. N. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9457-0 · Cited by 51
Antiviral biomaterials
Huang, X., Xu, W., Li, M., Zhang, P., Zhang, Y. S., Ding, J., & Chen, X. (2021) · Matter · doi:10.1016/j.matt.2021.03.016 · Cited by 45
Hyaluronic acid/alginate-based biomimetic hydrogel membranes for accelerated diabetic wound repair
Khaliq, T., Sohail, M. F., Minhas, M. U., Mahmood, A., Munir, A., Qalawlus, A. H. M., Jabeen, N., Kousar, M., & Anwar, Z. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123244 · Cited by 46
Electrospun fibers for the treatment of skin diseases
Gürtler, A.-L., Rades, T., & Heinz, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.009 · Cited by 43
Plant diversity patterns along an elevation gradient: the relative impact of environmental and spatial variation on plant diversity and assembly in arid and semi-arid regions
He, X., Arif, M., Zheng, J., Ni, X., Yuan, Z., Zhu, Q., Wang, J., Ding, D., & Li, C. (2023) · Frontiers in Environmental Science · doi:10.3389/fenvs.2023.1021157 · Cited by 42
Antiviral Effects of Lactococcus lactis on Feline Calicivirus, A Human Norovirus Surrogate
Aboubakr, H. A., El-Banna, A. A., Youssef, M. M., Sohaimy, S. A. E., & Goyal, S. M. (2014) · Food and Environmental Virology · doi:10.1007/s12560-014-9164-2 · Cited by 42
Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis
Rajan, S. S., Cavera, V. L., Zhang, X., Singh, Y., Chikindas, M. L., & Sinko, P. J. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02446-14 · Cited by 35
Novel Dietary Approach with Probiotics, Prebiotics, and Synbiotics to Mitigate Antimicrobial Resistance and Subsequent Out Marketplace of Antimicrobial Agents: A Review
Habteweld, H. A., & Asfaw, T. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s413416 · Cited by 36
The Role of Whey in Functional Microorganism Growth and Metabolite Generation: A Biotechnological Perspective
Malos, I. G., Ghizdareanu, A.-I., Vidu, L., Matei, C. B., & Pasarin, D. (2025) · Foods · doi:10.3390/foods14091488 · Cited by 44
Interactions between commensal bacteria and viral infection: insights for viral disease control in farmed animals
Ran, C., Li, Y., Ma, X., Xie, Y., Xie, M., Zhang, Y., Zhou, W., Yang, Y., Zhang, Z., Zhou, L., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1721-5 · Cited by 32
Genomic and functional characterization of bacteriocinogenic lactic acid bacteria isolated from Boza, a traditional cereal-based beverage
Queiroz, L. L., Hoffmann, C., Lacorte, G. A., Franco, B. D. G. D. M., & Todorov, S. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-05086-1 · Cited by 27
The Fight against the Carcinogenic Epstein-Barr Virus: Gut Microbiota, Natural Medicines, and Beyond
Eladwy, R. A., Vu, H. T., Shah, R., Li, C. G., Chang, D., & Bhuyan, D. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021716 · Cited by 27
Prophylactic effects of probiotics on respiratory viruses including COVID-19: a review
Lee, N., & Paik, H. (2021) · Food Science and Biotechnology · doi:10.1007/s10068-021-00913-z · Cited by 23
Precision Postbiotics and Mental Health: the Management of Post-COVID-19 Complications
Pandey, M., Bhati, A., Priya, K. G. G. L. S., Sharma, K. K., & Singhal, B. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09875-4 · Cited by 24
Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic
Loffredo, M. R., Nencioni, L., Mangoni, M. L., & Casciaro, B. (2023) · Journal of Peptide Science · doi:10.1002/psc.3534 · Cited by 25
Expanding Layers of Bacteriocin Applications: From Food Preservation to Human Health Interventions
Demirgül, F., Kaya, H. İ., Uçar, R. A., Mitaf, N. A., & Şimşek, Ö. (2025) · Fermentation · doi:10.3390/fermentation11030142 · Cited by 24
Antifungal nanofibers made by controlled release of sea animal derived peptide
Viana, J. F. C., Carrijo, J., de Freitas, C. G., Paul, A., Alcaraz‐Espinoza, J. J., Lacorte, C. C., Migliolo, L., Andrade, C. A. S., Falcão, R., Santos, N. C., et al. (2015) · Nanoscale · doi:10.1039/c5nr00767d · Cited by 22
Could Probiotics and Postbiotics Function as “Silver Bullet” in the Post-COVID-19 Era?
Todorov, S. D., Tagg, J. R., & Иванова, И. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09833-0 · Cited by 21
In-silico design and molecular docking evaluation of peptides derivatives from bacteriocins and porcine beta defensin-2 as inhibitors of Hepatitis E virus capsid protein
Quintero-Gil, C., Parra-Suescún, J., Herrera, A. L., & Ordúz, S. (2017) · VirusDisease · doi:10.1007/s13337-017-0383-7 · Cited by 21
2,3-Dihydroxybenzoic Acid Electrospun into Poly(d,l-lactide) (PDLLA)/Poly(ethylene oxide) (PEO) Nanofibers Inhibited the Growth of Gram-Positive and Gram-Negative Bacteria
Ahire, J. J., Neppalli, R., Heunis, T. D. J., van Reenen, A. J., & Dicks, L. M. T. (2014) · Current Microbiology · doi:10.1007/s00284-014-0635-3 · Cited by 19
Recent advances in antiviral effects of probiotics: potential mechanism study in prevention and treatment of SARS-CoV-2
Montazeri‐Najafabady, N., Kazemi, K., & Gholami, A. (2022) · Biologia · doi:10.1007/s11756-022-01147-y · Cited by 16
Nanoparticles and essential oils with antiviral activity on packaging and surfaces: An overview of their selection and application
Márquez, R., Zwilling, J. D., Zambrano, F., Tolosa, L. I., Marquez, M. E., Venditti, R. A., Jameel, H., & González, R. (2022) · Journal of Surfactants and Detergents · doi:10.1002/jsde.12609 · Cited by 15
The Effectiveness of Probiotics against Viral Infections: A Rapid Review with Focus on SARS-CoV-2 Infection
Salman, J. A. S., Mahmood, N. N., Abdulsattar, B. O., & Abid, H. A. (2020) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2020.5483 · Cited by 15
Innovative Approaches to Combat Antimicrobial Resistance: A Review of Emerging Therapies and Technologies
Rahman, M. U., Shah, J. A., Khan, M. N., Bilal, H., Zhu, D., Du, Z., & Mu, D. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10676-2 · Cited by 15
The Antiviral Activity of Probiotic Metabolites
Kassaa, I. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-49688-7_4 · Cited by 14
Oxygen-Limiting Growth Conditions and Deletion of the Transition State Regulator Protein Abrb in Bacillus subtilis 6633 Result in an Increase in Subtilosin Production and a Decrease in Subtilin Production
Stein, T. H. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09547-4 · Cited by 14
Bactericidal and non‐cytotoxic activity of bacteriocin produced by Lacticaseibacillus paracasei F9 ‐02 and evaluation of its tolerance to various physico‐chemical conditions
Duraisamy, S., Sathyan, A., Balakrishnan, S., Subramani, P., Prahalathan, C., & Kumarasamy, A. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16327 · Cited by 12
The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment
Al-Khazaleh, A. K., Chang, D., Münch, G. W., & Bhuyan, D. J. (2024) · Cancers · doi:10.3390/cancers16081464 · Cited by 12
Nature-inspired male contraceptive and spermicidal products
Hifnawy, M. S., Aboseada, M. A., Hassan, H. M., Tohamy, A. F., Naggar, E. M. B. E., & Abdelmohsen, U. R. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09721-5 · Cited by 14
Enhancing antibacterial properties of bacteriocins using combination therapy
Sharma, P., & Yadav, M. (2022) · Journal of Applied Biology & Biotechnology · doi:10.7324/jabb.2023.110206 · Cited by 12
Subtilosin A production by Bacillus subtilis KATMIRA1933 and colony morphology are influenced by the growth medium
Nikiforova, O. A., Klykov, S. P., Volski, A., Dicks, L. M. T., & Chikindas, M. L. (2015) · Annals of Microbiology · doi:10.1007/s13213-015-1149-3 · Cited by 14
Characterization of Tonsil Microbiota and Their Effect on Adenovirus Reactivation in Tonsillectomy Samples
Wang, L., Xu, D., Huang, Q., Yang, G., Zhang, M., Bi, J., Shan, J., Li, E., & He, S. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01246-21 · Cited by 11
Evaluation of an Industrial Soybean Byproduct for the Potential Development of a Probiotic Animal Feed Additive with Bacillus Species
Mahoney, R., Weeks, R. M., Zheng, T., Huang, Q., Dai, W., Cao, Y., Liu, G., Guo, Y., Chistyakov, V. A., & Chikindas, M. L. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09619-5 · Cited by 11
Draft Genome Sequence of Bacillus subtilis strain KATMIRA1933
Karlyshev, A. V., Melnikov, V. G., & Chikindas, M. L. (2014) · Genome Announcements · doi:10.1128/genomea.00619-14 · Cited by 11
Antibacterial and Antiviral Nanofibrous Membranes
Bakhshi, A., Naghib, S. M., & Rabiee, N. (2024) · ACS symposium series · doi:10.1021/bk-2024-1472.ch002 · Cited by 10
Antiviral Mechanisms Related to Lactic Acid Bacteria and Fermented Food Products
Özel, Z. B., & Öztürk, H. İ. (2020) · Biotech Studies · doi:10.38042/biost.2020.29.01.03 · Cited by 10
Bacteriocins as Antimicrobial and Antibiofilm Agents
dos Santos, V. L., Drummond, R. M. N., & Dias-Souza, M. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-444-63660-7.00016-4 · Cited by 10
Postbiotic Potential of Newly Isolated Riboflavin-Overproducing Lactiplantibacillus plantarum Strains
Scauro, A., Rocchetti, M. T., Soccio, M., la Gatta, B., Liberatore, M. T., Simone, N. D., Spano, G., Fiocco, D., & Russo, P. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10538-x · Cited by 10
Exploring preventive and treatment strategies for oral cancer: Modulation of signaling pathways and microbiota by probiotics
Saadh, M. J., Allela, O. Q. B., Kareem, R. A., Sanghvi, G. V., Ballal, S., Naidu, K. S., Bareja, L., Chahar, M., Gupta, S., Sameer, H. N., et al. (2025) · Gene · doi:10.1016/j.gene.2025.149380 · Cited by 9
Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses
Teiar, R., Sané, F., Erol, İ., Nekoua, M. P., Lecouturier, D., Boukherroub, R., Durdağı, S., Hober, D., & Drider, D. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04002-7 · Cited by 8
A hydrogen-bonded curdlan-chitosan/polyvinyl alcohol edible dual functional hydrogel bandage against MRSA promotes wound healing
Gao, Y., Wang, H., & Niu, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129351 · Cited by 7
A nanofiber based antiviral (TAF) prodrug delivery system
Dart, A., Roy, D., Vlaskin, V. A., Limqueco, E., Lowe, N. M., Srinivasan, S., Ratner, D. M., Bhave, M. R., Stayton, P. S., & Kingshott, P. (2022) · Biomaterials Advances · doi:10.1016/j.msec.2021.112626 · Cited by 7
Probiotics and Antimicrobial Peptides: The Creatures’ and Substances’ Future in the Twenty-First Century: An Opinion Letter
Chikindas, M. L. (2014) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-014-9161-7 · Cited by 7
Bacteriocin: the avenues of innovation towards applied microbiology
Hashim, H. (2018) · Pure and Applied Biology · doi:10.19045/bspab.2018.700205 · Cited by 7
Biotechnological potential of lactic acid bacteria derived bacteriocins in sustainable food preservation
Mekala, P. N., & Ansari, R. M. H. (2023) · World Journal of Biology Pharmacy and Health Sciences · doi:10.30574/wjbphs.2023.14.3.0245 · Cited by 5
Bacteriocins and Nanotechnology
Dicks, L. M. T., Staden, A. D. P. V., & Klumperman, B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-41625-2.00007-7 · Cited by 5
The Diversity of Bacteriocin and Its Antiviral Potential: An Overview
Elalem, N. (2021) · The Egyptian Journal of Medical Microbiology · doi:10.21608/ejmm.2021.203649 · Cited by 4
Advances on virucidal textile coatings
Calais, G. B., Bataglioli, R. A., de Freitas, E. D., Mondal, M. I. H., & Beppu, M. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90477-3.00002-x · Cited by 4
Progress for Antiviral Development in Latin America
Castilla, V., Sepulveda, C. S., García, C. C., & Damonte, E. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-54567-7_22 · Cited by 3
Probiotics and immunity: An overview
Sil, M., Mitra, S., & Goswami, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85730-7.00007-2 · Cited by 3
Antimicrobial Peptide and Toxin-Based Mutualism: Obligate Symbiotic Entomopathogenic Nematode—Bacterium Associations
Banerjee, A., & Saha, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-5617-0_4 · Cited by 2
Literature search and data collection on RA for human health for microorganisms used as plant protection products
Hackl, E., Pacher-Zavisin, M. C., Sedman, L., Arthaber, S., Bernkopf, U., Brader, G., Gorfer, M., Mitter, B., Mitropoulou, A., Schmoll, M., et al. (2015) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2015.en-801 · Cited by 2
Rising Threats of Viral Infections: Exploring Probiotics as Antiviral Agents
Bhat, H. M., Nazir, R., & Kashoo, Z. A. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01378-4 · Cited by 1

Authors: Torres, N. I., Noll, K. S., Xu, S., Li, J., Huang, Q., Sinko, P. J., Wachsman, M. B., & Chikindas, M. L.
Affiliations: Universidad de Buenos Aires (AR)
Rutgers, The State University of New Jersey (US)
Corresponding author: Chikindas, Michael L.
ORCID: Torres, Nicolás I.
Xu, Shiqi
Li, Ji
Huang, Qingrong
Sinko, Patrick J.
Chikindas, Michael L.
Venue: Probiotics and Antimicrobial Proteins
Publisher: Springer Science and Business Media LLC
Published: 2013-01-13
Volume: 5
Issue: 1
Pages: 26-35
ISSN: 1867-1306 (ISSN-L)
1867-1314
DOI: 10.1007/s12602-012-9123-x
PMC: PMC3637976
OpenAlex: W2050952290
Cited by: 122
References: 55
Citations by year: 2026: 3 · 2025: 6 · 2024: 12 · 2023: 15 · 2022: 13 · 2021: 19 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 13 · 2013: 2
FWCI: 8.58
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Probiotics and Antimicrobial Proteins (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI084137)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords: antimicrobial peptides, herpes simplex virus type 1, acyclovir resistance, virucidal activity, nanofibers, polyvinyl alcohol, electrospinning, drug delivery, skin toxicity, Bacillus amyloliquefaciens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks