Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review
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To determine the effectiveness of weight loss intervention for breast cancer survivors. From October 2012 until March 2013, Pubmed was searched for weight loss intervention trials that reported body weight or weight loss as a primary outcome. Fifteen of these studies are included in this review. Of the 15 studies included, 14 resulted in statistically significant weight loss and 10 obtained clinically meaningful weight loss of ≥5 % from baseline. Evidence was provided of the feasibility of using several methods of weight loss intervention (telephone, in person, individual, group). Successful intervention used a comprehensive approach, with dietary, physical activity, and behavior modification components. Weight loss improved cardiovascular risk factors and markers of glucose homeostasis. However, there is insufficient evidence to identify the components of this intervention that led to successful weight loss, or to determine the weight loss necessary to affect biomarkers linked to breast cancer prognosis. The small number of randomized controlled trials shared several limitations, including small study sample sizes and lack of follow-up beyond 6 months. Intervention with longer follow-up revealed weight regain, showing the importance of considering strategies to promote long-term weight maintenance. Weight loss intervention for breast cancer survivors can lead to statistically significant and clinically meaningful weight loss, but the limited number of interventional studies, small sample sizes, and short duration of follow-up in many studies limit our ability to draw conclusions regarding the most efficacious weight-loss intervention after a breast cancer diagnosis. The findings to date are encouraging, but research on the effect of weight loss on breast cancer recurrence and mortality, and on prevention of weight gain for women newly diagnosed with breast cancer, is needed.
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Variability in intervention design and delivery and mixed weight loss results suggest a lack of clarity in the literature on mechanisms important to weight loss among breast cancer survivors.
“The variability in intervention design/delivery and mixed weight loss results suggest an existing lack of clarity in the literature on the mechanisms that are important to weight loss among breast cancer survivors [29]”
From A qualitative evaluation of a group phone-based weight loss intervention for rural breast cancer survivors: Themes and mechanisms of success (2016) · cites this paper as [29]
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Weight Management: Perception, Interest, and Preferences in Adult Cancer Survivors
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Nutrition and Weight Management
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Obesity, Weight Gain, and Weight Management
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Self-citationTumour stage and age relate with body composition in breast cancer patients: cohort study
Doś, J., Rosochowicz, M. A., Mocydlarz-Adamcewicz, M., Górecki, M., & Górska-Doś, M. (2026) · Reports of Practical Oncology & Radiotherapy · doi:10.5603/rpor.115004
- Authors
- Playdon, M., Thomas, G., Sanft, T., Harrigan, M., Ligibel, J., & Irwin, M.
- Affiliations
- Yale University (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Irwin, Melinda
- Venue
- Current Breast Cancer Reports
- Published
- 2013-05-17
- Volume
- 5
- Issue
- 3
- Pages
- 222-246
- ISSN
- 1943-4588 (ISSN-L)
- 1943-4596
- PMC
- PMC4655116
- OpenAlex
- W2094480921
- Cited by
- 62
- References
- 61
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Breast Cancer Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (T32CA105666)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- breast cancer survivors, weight loss interventions, body weight, weight regain, weight maintenance, dietary intervention, physical activity, behavior modification, cardiovascular risk factors, glucose homeostasis, postmenopausal weight gain, breast cancer recurrence
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