Cited by 64Cancer Risks and FactorsCancer survivorship and careObesity, Physical Activity, Diet

Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review

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Playdon, Mary, Thomas, Gwendolyn, Sanft, Tara, Harrigan, Maura, Ligibel, Jennifer, Irwin, Melinda·2013·Current Breast Cancer Reports

Abstract

To determine the effectiveness of weight loss intervention for breast cancer survivors. From October 2012 until March 2013, Pubmed was searched for weight loss intervention trials that reported body weight or weight loss as a primary outcome. Fifteen of these studies are included in this review. Of the 15 studies included, 14 resulted in statistically significant weight loss and 10 obtained clinically meaningful weight loss of ≥5 % from baseline. Evidence was provided of the feasibility of using several methods of weight loss intervention (telephone, in person, individual, group). Successful intervention used a comprehensive approach, with dietary, physical activity, and behavior modification components. Weight loss improved cardiovascular risk factors and markers of glucose homeostasis. However, there is insufficient evidence to identify the components of this intervention that led to successful weight loss, or to determine the weight loss necessary to affect biomarkers linked to breast cancer prognosis. The small number of randomized controlled trials shared several limitations, including small study sample sizes and lack of follow-up beyond 6 months. Intervention with longer follow-up revealed weight regain, showing the importance of considering strategies to promote long-term weight maintenance. Weight loss intervention for breast cancer survivors can lead to statistically significant and clinically meaningful weight loss, but the limited number of interventional studies, small sample sizes, and short duration of follow-up in many studies limit our ability to draw conclusions regarding the most efficacious weight-loss intervention after a breast cancer diagnosis. The findings to date are encouraging, but research on the effect of weight loss on breast cancer recurrence and mortality, and on prevention of weight gain for women newly diagnosed with breast cancer, is needed.

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Authors
Playdon, M., Thomas, G., Sanft, T., Harrigan, M., Ligibel, J., & Irwin, M.
Affiliations
  • Yale University (US)
  • Dana-Farber Cancer Institute (US)
Corresponding author
Irwin, Melinda
Venue
Current Breast Cancer Reports
Published
2013-05-17
Volume
5
Issue
3
Pages
222-246
ISSN
  • 1943-4588 (ISSN-L)
  • 1943-4596
OpenAlex
W2094480921
Cited by
62
References
61
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 1
FWCI
0.21
Type
journal article
Language
en
Open access
Locations
  • Current Breast Cancer Reports (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (T32CA105666)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
breast cancer survivors, weight loss interventions, body weight, weight regain, weight maintenance, dietary intervention, physical activity, behavior modification, cardiovascular risk factors, glucose homeostasis, postmenopausal weight gain, breast cancer recurrence

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