A Preliminary Study: Efficacy of Mindfulness-Based Cognitive Therapy versus Sertraline as First-line Treatments for Major Depressive Disorder
Open accessAbstract
Major depressive disorder (MDD) is the leading cause of disability in the developed world, yet broadly effective treatments remain elusive. The primary aim of this pilot study was to investigate the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) monotherapy, compared to sertraline monotherapy, for patients with acute MDD. This open-label, nonrandomized controlled trial examined a MBCT cohort (N=23) recruited to match the gender, age, and depression severity of a depressed control group (N=20) that completed 8 weeks of monotherapy with the antidepressant sertraline. The 17-item clinician-rated Hamilton Depression Severity Rating Scale (HAMD-17) was the primary outcome measure of depression to assess overall change after 8 weeks and rates of response and remission. The 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR16) was the secondary outcome measure to further assess depression severity. Both cohorts were demographically similar and showed significant improvement in depression ratings. No difference was found in the degree of change in HAMD-17 scores (t(34) = 1.42, p = .165) between groups. Secondary analysis showed statistically significant differences in mean scores of the QIDS-SR16 (t (32) = 4.39, p < 0.0001), with the MCBT group showing greater mean improvement. This study was limited by the small sample size and non-randomized, non-blinded design. Preliminary findings suggest that an 8-week course of MBCT monotherapy may be effective in treating MDD and a viable alternative to antidepressant medication. Greater changes in the self-rated QIDS-SR16 for the MBCT cohort raise the possibility that patients derive additional subjective benefit from enhanced self-efficacy skills.
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Where substantially larger effects have been observed, these have been based on small samples.
“Where substantially larger effects have been observed, these have been based on small samples (Barnhofer et al. 2009; Chiesa et al. 2015; Eisendrath et al. 2015; Kingston et al. 2007).”
From The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Real-World Healthcare Services (2020) · cites this paper as Eisendrath et al. 2015
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MethodInfluentialUsing Self-Report Assessment Methods to Explore Facets of Mindfulness
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MethodIntroduction to Statistical Mediation Analysis
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“…were only available for the MBCT group, we were unable to complete a formal mediation analysis wherein a set of linear models tests whether the relationship of type of treatment received to outcome is accounted for the change in variable which, in turn, affects the outcome (MacKinnon 2008).”
MethodRush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · cited 2× · see citing works
“The 16- item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16) (Rush et al. 2003) was the secondary outcome measure of self-reported depression severity.”
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BackgroundEvidence-based health policy—lessons from the Global Burden of Disease Study
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“Major depressive disorder (MDD) is the number one cause of disability in developed countries and is projected to become the second cause of disability worldwide by 2020 (WHO 2001; Murray and Lopez 1996), yet broadly effective treatments remain elusive.”
BackgroundComplementary and alternative medicine use among adults: United States, 2002
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“Patients appear interested in such alternative approaches that enhance self-efficacy and offer skills to autonomously regulate dysphoric moods (Barnes et al. 2004).”
BackgroundMa, S. H., & Teasdale, J. D. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.1.31 · Cited by 1,390 · cited 1× · see citing works
“It has demonstrated effectiveness when compared to routine clinical management (Godfrin and van Heeringen 2010; Ma and Teasdale 2004; Teasdale et al. 2000), and yields equivalent efficacy to maintenance antidepressants in preventing relapse (Kuyken et al. 2010a; Segal et al. 2010).”
BackgroundMindfulness-based cognitive therapy for depression
TEASDALE, J. D. (2006) · Routledge eBooks · doi:10.4324/9780203098899-33 · Cited by 1,331 · see citing works
Response styles and the duration of episodes of depressed mood.
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MethodMindfulness-Based Cognitive Therapy for Depression
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Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression
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BackgroundMechanisms of mindfulness: emotion regulation following a focused breathing induction
Arch, J. J., & Craske, M. G. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.12.007 · Cited by 1,005 · cited 1× · see citing works
“It’s believed that MBCT’s putative mechanisms of action include enhanced mindfulness (Kuyken et al. 2010b), improved emotional regulation (Arch and Craske 2006), increased self-compassion and acceptance (Kuyken et al. 2008), reduced rumination (Nolen-Hoeksema and Morrow 1991), and the expanded…”
BackgroundKoolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · cited 1× · see citing works
“Meditation may enhance executive control areas (e.g., the dorsolateral prefrontal cortex and dorsal anterior cingulate) and regulation of ventral affective processing areas (e.g., the amygdala and ventrolateral prefrontal cortex) (Koolschijn et al. 2009).”
BackgroundFresco, D. M., Moore, M. T., van Dulmen, M. H. M., Segal, Z. V., Ma, S. H., Teasdale, J. D., & Williams, J. M. G. (2007) · Behavior Therapy · doi:10.1016/j.beth.2006.08.003 · Cited by 810 · cited 1× · see citing works
““Decentering,” another key term used in the mindfulness literature, has been defined as the ability to view one’s thoughts and feelings as temporary mental events, as opposed to concrete reflections about oneself or others (Fresco et al. 2007).”
BackgroundHow does mindfulness-based cognitive therapy work?
Kuyken, W., Watkins, E., Holden, E., White, K., Taylor, R. S., Byford, S., Evans, A., Radford, S., Teasdale, J. D., & Dalgleish, T. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.08.003 · Cited by 809 · cited 4× · see citing works
“It has demonstrated effectiveness when compared to routine clinical management (Godfrin and van Heeringen 2010; Ma and Teasdale 2004; Teasdale et al. 2000), and yields equivalent efficacy to maintenance antidepressants in preventing relapse (Kuyken et al. 2010a; Segal et al. 2010).”
BackgroundResultInfluentialMindfulness-based cognitive therapy to prevent relapse in recurrent depression.
Kuyken, W., Byford, S., Taylor, R. S., Watkins, E., Holden, E., White, K., Barrett, B., Byng, R., Evans, A., Mullan, E., et al. (2008) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0013786 · Cited by 770 · cited 2× · see citing works
“…include enhanced mindfulness (Kuyken et al. 2010b), improved emotional regulation (Arch and Craske 2006), increased self-compassion and acceptance (Kuyken et al. 2008), reduced rumination (Nolen-Hoeksema and Morrow 1991), and the expanded ability to “decenter” from one’s automatic thoughts and…”
BackgroundAbnormal gray and white matter volume in delusional infestation
Wolf, R. C., Huber, M. K., Depping, M. S., Thomann, P. A., Kärner, M., Lepping, P., & Freudenmann, R. W. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.06.004 · Cited by 606 · see citing works
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“Because the combined subscales of isolation and self-judgment have previously been demonstrated to play a mediating role in MBCT’s effect in relapse prevention (Van Dam et al. 2010), the version of the SCS which measures these factors was included.”
BackgroundSegal, Z. V., Bieling, P., Young, T., MacQueen, G., Cooke, R., Martin, L., Bloch, R., & Levitan, R. D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.168 · Cited by 429 · cited 2× · see citing works
“It has demonstrated effectiveness when compared to routine clinical management (Godfrin and van Heeringen 2010; Ma and Teasdale 2004; Teasdale et al. 2000), and yields equivalent efficacy to maintenance antidepressants in preventing relapse (Kuyken et al. 2010a; Segal et al. 2010).”
BackgroundThe role of self-compassion in development: a healthier way to relate to oneself
Neff, K. D. (2009) · Human Development · doi:10.1159/000215071 · Cited by 419 · cited 2× · see citing works
“The 26-item SelfCompassion Scale (SCS) (Neff 2009), subdivided into six subscales: self-kindness, self-judgment, isolation, overidentification, common humanity, and mindfulness, was used to measure mean levels of self-compassion.”
MethodMindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study
Barnhofer, T., Crane, C., Hargus, E., Amarasinghe, M., Winder, R., & Williams, J. M. G. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.01.019 · Cited by 396 · cited 1× · see citing works
“These studies followed works by Barnhofer et al. (2009) and Kingston et al. (2007) demonstrating that MBCT augmentation was more efficacious than treatment as usual (typically antidepressant management) in reducing the residual symptoms of chronic depression.”
Treatment-resistant depressed patients show a good response to Mindfulness-based Cognitive Therapy
Kenny, M. A., & Williams, J. M. G. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2006.04.008 · Cited by 364 · cited 1× · see citing works
“Open label trials of MBCT augmentation of antidepressants for treatment-resistant depression showed effect sizes of 1.0 (Cohen’s D) in both Kenny and Williams (2007) and Eisendrath et al. (2008) hence making MBCT a realistically viable treatment to investigate as a stand-alone treatment for…”
InfluentialFinucane, A., & Mercer, S. W. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-14 · Cited by 308 · cited 2× · see citing works
“Through these emotion regulation mechanisms (i.e., mindfulness, self-compassion, rumination, decentering), MBCT also shows promise in reducing symptoms of anxiety, which commonly co-occur with depression (Finucane and Mercer 2006).”
BackgroundThase, M. E., Haight, B. R., Richard, N., Rockett, C. B., Mitton, M., Modell, J. G., VanMeter, S., Harriett, A. E., & Wang, Y. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0803 · Cited by 304 · cited 2× · see citing works
“Moreover, there are well-documented problems with antidepressant adherence, side effects, drug interactions, cost, and personal preference (Thase et al., 2005).”
BackgroundGodfrin, K. A., & van Heeringen, C. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.04.006 · Cited by 296 · see citing works
Dysregulated relationship of inflammation and oxidative stress in major depression
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“A description and the results of that trial have been previously published (Rawdin et al., 2012).”
BackgroundSelf-citationSdol, E. (2009) · Cited by 249 · see citing works
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“These studies followed works by Barnhofer et al. (2009) and Kingston et al. (2007) demonstrating that MBCT augmentation was more efficacious than treatment as usual (typically antidepressant management) in reducing the residual symptoms of chronic depression.”
PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW
Cuijpers, P. J., Reynolds, C. F., Donker, T., Li, J., Andersson, G., & Beekman, A. T. F. (2012) · Depression and Anxiety · doi:10.1002/da.21985 · Cited by 166 · cited 1× · see citing works
“While existing psychotherapy treatments offer similar efficacy to medication for treatment of less severe MDD (Cuijpers et al. 2012), there are often significant barriers to access for patients wishing to pursue psychotherapy as a first-line treatment.”
BackgroundMindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A Pilot Study
Eisendrath, S. J., Delucchi, K., Bitner, R., Fenimore, P., Smit, M., & McLane, M. (2008) · Psychotherapy and Psychosomatics · doi:10.1159/000142525 · Cited by 148 · cited 1× · see citing works
“…label trials of MBCT augmentation of antidepressants for treatment-resistant depression showed effect sizes of 1.0 (Cohen’s D) in both Kenny and Williams (2007) and Eisendrath et al. (2008) hence making MBCT a realistically viable treatment to investigate as a stand-alone treatment for depression.”
BackgroundInfluentialSelf-citationManicavasgar, V., Parker, G., & Perich, T. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.027 · Cited by 136 · cited 2× · see citing works
“For example, Manicavasgar et al. (2011) compared MBCT and CBT in a population with MDD and found similar efficacy in both groups, although their work had the confounding effect of 57% of their participants being on concurrent antidepressants.”
BackgroundMethodMeta-analysis of relapse prevention antidepressant trials in depressive disorders
Glue, P., Donovan, M. R., Kolluri, S., & Emir, B. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048671003705441 · Cited by 100 · cited 1× · see citing works
“MBCT’s proven effectiveness to prevent depression relapse upon remission, contrasts with standard medication management for recurrent MDD, in which relapse prevention has been noted to last for only a relatively limited period after drug discontinuation (Dunlop et al. 2012; Glue et al. 2010).”
BackgroundDunlop, B. W., Thase, M. E., Wun, C., Fayyad, R. S., Guico‐Pabia, C. J., Musgnung, J. J., & Ninan, P. T. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.153 · Cited by 72 · cited 1× · see citing works
“MBCT’s proven effectiveness to prevent depression relapse upon remission, contrasts with standard medication management for recurrent MDD, in which relapse prevention has been noted to last for only a relatively limited period after drug discontinuation (Dunlop et al. 2012; Glue et al. 2010).”
BackgroundChiesa, A., Mandelli, L., & Serretti, A. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0407 · Cited by 64 · cited 1× · see citing works
“Chiesa et al. (2012) noted that in a sample of participants randomized to MBCT or psychoeducation, MBCTwas more efficacious in reducing residual symptoms after initial antidepressant treatment.”
BackgroundAdapting Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression
Eisendrath, S., Chartier, M., & McLane, M. (2011) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2010.05.004 · Cited by 60 · cited 1× · see citing works
“Most of these adaptations were derived from our work with individuals suffering from treatment-resistant depression (Eisendrath et al. 2011).”
BackgroundSelf-citationOmidi, A., Mohammadkhani, P., Mohammadi, A., & Zargar, F. (2013) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.8018 · Cited by 52 · cited 1× · see citing works
“Omidi et al. (2013) found similar efficacy of CBT and MBCT in reducing depressive symptoms and superiority to medication alone, although 100 % of participants were on concurrent antidepressants.”
ResultKuyken, W., Byford, S., Byng, R., Dalgleish, T., Lewis, G., Taylor, R., Watkins, E. R., Hayes, R., Lanham, P., Kessler, D., et al. (2010) · Trials · doi:10.1186/1745-6215-11-99 · Cited by 48 · see citing works
Psychomotor retardation and agitation in depression
Avery, D., & Silverman, J. (1984) · Journal of Affective Disorders · doi:10.1016/0165-0327(84)90066-1 · Cited by 44 · cited 1× · see citing works
“The manual was adapted to cater to an acutely depressed patient population that often suffers from increased agitation, decreased attention span, and executive impairments (Avery and Silverman 1984).”
MethodClinical outcome and tolerability of sertraline in major depression
Mauri, M. C., Laini, V., Cerveri, G., Scalvini, M. E., Volonteri, L. S., Regispani, F., Malvini, L., Manfré, S., Boscati, L., & Panza, G. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00314-1 · Cited by 36 · cited 2× · see citing works
“All individuals had plasma concentrations within the range of published steady state concentrations for sertraline at therapeutic doses (Mauri et al., 2002), indicating good compliance with medication treatment.”
BackgroundOmidi, A., Hamidian, S., Mousavinasab, S. M., & Naziri, G. (2013) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.8024 · Cited by 22 · cited 1× · see citing works
“Hamidian et al. (2013) noted that augmentation with MBCT could improve outcomes in dysthymia compared to imipramine treatment alone.”
ResultShawyer, F., Meadows, G. N., Judd, F. K., Martin, P. R., Segal, Z. V., & Piterman, L. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-3 · Cited by 18 · cited 2× · see citing works
“Although individuals are required to invest more time and energy in MBCT than in medication management during the first 8 weeks of treatment, studies indicate that MBCTmay be cost effective in comparison to maintenance medications over time (Kuyken et al. 2010b; Shawyer et al. 2012).”
Background
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Cited by
Sorted by citations
Parsons, C. E., Crane, C., Parsons, L. J., Fjorback, L. O., & Kuyken, W. (2017) · Behaviour Research and Therapy · doi:10.1016/j.brat.2017.05.004 · Cited by 550 · see citing works
“Two of the 49 studies reported on associations between mindfulness practice and outcomes (Carmody et al., 2008; Eisendrath et al., 2015) but the mean mindfulness practice data were not available.”
BackgroundKing, A. P., Block, S. R., Sripada, R. K., Rauch, S., Giardino, N., Favorite, T., Angstadt, M., Kessler, D., Welsh, R., & Liberzon, I. (2016) · Depression and Anxiety · doi:10.1002/da.22481 · Cited by 225 · see citing works
“Several RCTs have found mindfulness-based cognitive therapy (MBCT) to be effective for preventing depression relapse,[11–13] and there is accumulating evidence that MBCT and mindfulness-based stress reduction (MBSR) may be helpful for active depression [14, 15] and generalized anxiety disorder (GAD).”
BackgroundThe Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Real-World Healthcare Services
Tickell, A., Ball, S., Bernard, P., Kuyken, W., Marx, R., Pack, S., Strauss, C., Sweeney, T., & Crane, C. (2020) · Mindfulness · doi:10.1007/s12671-018-1087-9 · Cited by 99 · see citing works
Clinical research challenges posed by difficult-to-treat depression.
Rush, A. J., Sackeim, H. A., Conway, C. R., Bunker, M. T., Hollon, S. D., Demyttenaere, K., Young, A. H., Aaronson, S. T., Dibué, M., Thase, M. E., et al. (2022) · Psychological Medicine · doi:10.1017/s0033291721004943 · Cited by 89 · see citing works
“…grit may provide therapeutic opportunities (Thase & Howland, 1994; Young, 2018), as in helping patients with DTD to identify psychological ‘ negative feedback loops ’ and trigger the use of specific psychotherapeutic strategies to mitigate their impact (Eisendrath et al., 2015; Lynch et al., 2020).”
King, A. P., Block, S. R., Sripada, R. K., Rauch, S. A. M., Porter, K. E., Favorite, T. K., Giardino, N., & Liberzon, I. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00154 · Cited by 64 · see citing works
Mindfulness-based cognitive therapy for residual depressive symptoms and relapse prophylaxis
Segal, Z. V., & Walsh, K. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000216 · Cited by 62 · see citing works
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Self-citationEbrahiminejad, S., Poursharifi, H., Roodsari, A. B., Zeinodini, Z., & Noorbakhsh, S. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.25116 · Cited by 41 · see citing works
“Since MBCT improves mood and its short-term implementation decreases fatigue and anxiety (9), and considering its effects on depression (10), anxiety, and psychological adaptability (11), it is somewhat surprising that few studies whether in Iran or other countries have addressed the effect of this therapy on social p…”
BackgroundLi, H., Yan, W., Wang, Q., Liu, L., Lin, X., Zhu, X., Su, S., Sun, W., Sui, M., Bao, Y., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.841461 · Cited by 34 · see citing works
An examination of concurrent and incremental validity of four mindfulness scales
Andrei, F., Vesely, A., & Siegling, A. B. (2016) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-016-9546-x · Cited by 29 · see citing works
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“Besides, research also demonstrated that both MM and HQ showed certain effects on stress reduction, improvement of sleep quality, and enhancement of self-efficacy [17, 25, 28, 29].”
ResultTime trends in the effects of mindfulness‐based cognitive therapy for depression: A meta‐analysis
Thimm, J. C., & Johnsen, T. J. (2020) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12642 · Cited by 17 · see citing works
Mindfulness-Based Workplace Interventions for Wellness Promotion
King, A. P. J. (2019) · Integrating psychiatry and primary care · doi:10.1007/978-3-030-04266-0_13 · Cited by 13 · see citing works
Mindfulness-Based Cognitive Therapy for Combat-Related Posttraumatic Stress Disorder
King, A. P. J., & Favorite, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-29866-5_15 · Cited by 7 · see citing works
Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression
Deen, S. R., Sipe, W. E. B., & Eisendrath, S. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-29866-5_12 · Cited by 7 · see citing works
Self-citationAltered auditory feedback perception following an 8-week mindfulness meditation practice
Miyashiro, D., Toyomura, A., Haitani, T., & Kumano, H. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.01.010 · Cited by 7 · see citing works
Hu, M., Wu, X., & Qiu, S. (2024) · BMC Medical Education · doi:10.1186/s12909-024-05554-4 · Cited by 5 · see citing works
“…research findings indicate that trait mindfulness significantly moderates the negative impact of perceived discrimination on WWB. Numerous clinical studies confirm the therapeutic advantages of trait mind-fulness in the psychological rehabilitation of individuals with disabilities [67, 68].”
BackgroundMindfulness as an Intervention for Depression
Metcalf, C. A., Gold, A. K., Davis, B. J., Sylvia, L. G., & Battle, C. L. (2019) · Psychiatric Annals · doi:10.3928/00485713-20181205-01 · Cited by 5 · see citing works
Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression
Sipe, W. E. B., & Eisendrath, S. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416031-6.00003-7 · Cited by 5 · see citing works
Self-citationStańko-Kaczmarek, M., Jankowski, T., Bartel, R., Stankowska, M., Andrzejewska, M., Rybakowski, F., Kaczmarek, L. D., & RYBAKOWSKI, J. K. (2025) · Journal of Happiness Studies · doi:10.1007/s10902-025-00932-1 · Cited by 4 · see citing works
“Traditional mindfulness-based interventions have been extensively studied and are recognized as effective nonpharmacological treatments for depression (Eisendrath et al., 2015; Teasdale et al., 2000).”
Jakary, A., Lupo, J., Mackin, S. R., Yin, A., Murray, D. E., Yang, T. T., Mukherjee, P., Larson, P. E. Z., Xu, D., Eisendrath, S. J., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.038 · Cited by 3 · see citing works
Self-citationUnderstanding the variability in ketamine’s efficacy in managing treatment-resistant depression
Bryan, J. (2024) · Discover Psychology · doi:10.1007/s44202-024-00277-5 · Cited by 3 · see citing works
“MBIs have been shown to effectively prevent depression relapse in individuals with a history of recurring depression [37] and reduce depressive symptoms in patients with active depression [15].”
Sweeney, T. (2016) · Nottingham ePrints (University of Nottingham) · Cited by 3 · see citing works
Experiences Questionnaire (EQ)
Naragon-Gainey, K., McMahon, T. P., Park, J., & Fresco, D. M. (2022) · Handbook of Assessment in Mindfulness Research · doi:10.1007/978-3-030-77644-2_42-1 · Cited by 2 · see citing works
The Brain Mechanism of Depression: Evidence from the Brain Midline Areas
刘, 永. (2016) · Advances in Psychology · doi:10.12677/ap.2016.611147 · Cited by 1 · see citing works
Luberto, C. M., Crute, S., Wang, A., Li, R., Yeh, G. Y., Huffman, J. C., Celano, C. M., Victorson, D. E., Hoeppner, B. B., & Park, E. R. (2024) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130241288213 · Cited by 1 · see citing works
Treating Acute Depression with Mindfulness‐Based Cognitive Therapy
Baer, R. A., & Walsh, E. C. (2015) · doi:10.1002/9781119114482.ch14 · Cited by 1 · see citing works
Complementary and Integrative Therapies for Older Age Bipolar Disorder
Poscablo-Stein, M. C., & Hermida, A. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-48912-4_10
Mindfulness Based Interventions in the Clinical Setting
MacKay, H. (2016) · National University System Repository (National University System)
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Harper, C. M. (2019) · UA Campus Repository (The University of Arizona)
Li, Y. (2024) · Transactions on Materials Biotechnology and Life Sciences · doi:10.62051/wrdh5n52
Sankar, K., Ramesh, S., Shanmugasundaram, N., Anbalagan, D., Sivaraman, V., Singaram, V., & Jeyabalan, S. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173959
Experiences Questionnaire (EQ)
Naragon‐Gainey, K., McMahon, T. P., Park, J., & Fresco, D. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-47219-0_42
- Authors
- Eisendrath, S. J., Gillung, E., Delucchi, K., Mathalon, D. H., Yang, T. T., Satre, D. D., Rosser, R., Sipe, W. E. B., & Wolkowitz, O. M.
- Affiliations
- University of California, San Francisco (US)
- San Francisco VA Medical Center (US)
- Kaiser Permanente (US)
- Corresponding author
- Eisendrath, Stuart J.
- Venue
- Mindfulness
- Published
- 2014-01-28
- Volume
- 6
- Issue
- 3
- Pages
- 475-482
- ISSN
- 1868-8527 (ISSN-L)
- 1868-8535
- PMC
- PMC4465797
- OpenAlex
- W2049201244
- Cited by
- 34
- References
- 51
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 6 · 2017: 2 · 2016: 10 · 2015: 2 · 2014: 1
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Mindfulness (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01at004572-04)
- National Institute of Mental Health (R01MH085734)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007762)
- National Center for Complementary and Integrative Health (R01AT004572.)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- mindfulness-based cognitive therapy, sertraline, major depressive disorder, monotherapy, antidepressant treatment, acute depression, treatment efficacy, self-efficacy, QIDS-SR16, Hamilton Depression Rating Scale
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