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Research progress of exosomes in the angiogenesis of digestive system tumour

Liu, Yuan, Wu, Hao, Sang, Yaodong, Chong, Wei, Shang, Liang, Li, Leping·2024·Discover Oncology
DOI 10.1007/s12672-024-00879-4PMC PMC10859358
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Abstract

Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes in the angiogenesis of digestive system tumours and highlight the clinical application prospects, directly used as targers or delivery vehicles, in antiangiogenic therapy.

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Fig. 1 Tumour-derived exosomes are generated through ESE, LSE, and ILVs in MVBs. After being secreted, exosomes can participate in the pro- and anti-angiogenesis of cancer by the cargos. ESE early-sorting endosome, LSE late-sorting endosome, ILVs intraluminal vesicles, MVBs multivesicular bodies, HUVEC human umbilical vein endothelial cell
Fig. 1 Tumour-derived exosomes are generated through ESE, LSE, and ILVs in MVBs. After being secreted, exosomes can participate in the pro- and anti-angiogenesis of cancer by the cargos. ESE early-sorting endosome, LSE late-sorting endosome, ILVs intraluminal vesicles, MVBs multivesicular bodies, HUVEC human umbilical vein endothelial cellCC BY · PubMed Central
Fig. 2 Exosomes in angiogenesis of digestive system tumours. The two light colored circles are factors of proangiogenesis. The first inner circle is protein; the outer circle is RNA. The factors in outermost dark circle are antiangiogenesis
Fig. 2 Exosomes in angiogenesis of digestive system tumours. The two light colored circles are factors of proangiogenesis. The first inner circle is protein; the outer circle is RNA. The factors in outermost dark circle are antiangiogenesisCC BY · PubMed Central

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Metadata

Authors
Liu, Y., Wu, H., Sang, Y., Chong, W., Shang, L., & Li, L.
Venue
Discover Oncology
Publisher
Springer Science and Business Media LLC
Published
2024-02-11
Volume
15
Issue
1
ISSN
2730-6011
DOI
10.1007/s12672-024-00879-4
PMC
PMC10859358
Cited by
7
References
0
Language
en
Licence
Funders
  • National Natural Scientific Foundation of China (82102702)
  • The Research Incubation Funding of Shandong Provincial Hospital (2020FY035)
  • Natural Science Foundation of Shandong Province of China (ZR2021QH141)
  • China Postdoctoral Science Foundation (2022M711970)
  • Clinical Medical Science and Technology Innovation Project of Jinan (202225046)
  • Youth Innovation Science and Technology Program of Shandong Provincial Universities (2022KJ187)
  • National Natural Science Foundation of China (82203854)
  • Key Research and Development Program of Shandong Province (No.2021CXGC011104)
  • Academic promotion programme of Shandong First Medical University (2019QL021)
  • Special Foundation for Taishan Scholars Program of Shandong Province (No.ts20190978)

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CoChat. (2026). Citation check: Research progress of exosomes in the angiogenesis of digestive system tumour. https://app.cochat.ai/papers/10.1007/s12672-024-00879-4
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Liu, Y., Wu, H., Sang, Y., Chong, W., Shang, L., & Li, L. (2024). Research progress of exosomes in the angiogenesis of digestive system tumour. Discover Oncology. https://doi.org/10.1007/s12672-024-00879-4