The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research
Open accessAbstract
Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a devastating neurological disease that has a morbidity and mortality rate higher than 50 %. Most of the traditional in vivo research has focused on the pathophysiological or morphological changes of large arteries after intracisternal blood injection. This was due to a widely held assumption that delayed vasospasm following SAH was the major cause of delayed cerebral ischemia and poor outcome. However, the results of the CONSCIOUS-1 trial implicated some other pathophysiological factors, independent of angiographic vasospasm, in contributing to the poor clinical outcome. The term early brain injury (EBI) has been coined and describes the immediate injury to the brain after SAH, before onset of delayed vasospasm. During the EBI period, a ruptured aneurysm brings on many physiological derangements such as increasing intracranial pressure, decreased cerebral blood flow, and global cerebral ischemia. These events initiate secondary injuries such as blood–brain barrier disruption, inflammation, and oxidative cascades that all ultimately lead to cell death. Given the fact that the reversal of vasospasm does not appear to improve patient outcome, it could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH. In this review, we provide an overview of the major advances in EBI after SAH research.
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2 retracted
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Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
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Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage.
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Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage
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Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage
Rabinstein, A. A., Friedman, J. A., Weigand, S. D., McClelland, R. L., Fulgham, J. R., Manno, E. M., Atkinson, J. L. D., & Wijdicks, E. F. M. (2004) · Stroke · doi:10.1161/01.str.0000133132.76983.8e · Cited by 498
Cited by
Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
Bothwell, S. W., Janigro, D., & Patabendige, A. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0129-6 · Cited by 319
Geraghty, J. R., & Testai, F. D. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0690-x · Cited by 304
Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage
Rass, V., & Helbok, R. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0990-3 · Cited by 253
Wang, Z., Guo, S., Wang, J., Shen, Y., Zhang, J., & Wu, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-12160-6 · Cited by 92
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Metadata
- Authors
- Fujii, M., Yan, J., Rolland, W. B., Soejima, Y., Caner, B., & Zhang, J. H.
- Venue
- Translational Stroke Research
- Published
- 2013-03-08
- Volume
- 4
- Issue
- 4
- Pages
- 432-446
- ISSN
- 1868-4483 (ISSN-L)
- 1868-601X
- OpenAlex
- W1967866252
- Cited by
- 493
- References
- 101
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- green
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