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Cited by 92Intracerebral and Subarachnoid Hemorrhage ResearchMangiferin and Mango ExtractsHeme Oxygenase-1 and Carbon Monoxide

Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation

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Wang, Zefeng, Guo, Songxue, Wang, Junxing, Shen, Yuanyuan, Zhang, Jianmin, Wu, Qun·2017·Scientific Reports
DOI 10.1038/s41598-017-12160-6PMC PMC5605716
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Abstract

Early brain injury (EBI) is involved in the process of cerebral tissue damage caused by subarachnoid hemorrhage (SAH), and multiple mechanisms, such as apoptosis and inflammation, participate in its development. Mangiferin (MF), a natural C-glucoside xanthone, has been reported to exert beneficial effects against several types of organ injury by influencing various biological progresses. The current study aimed to investigate the potential of MF to protect against EBI following SAH via histological and biological assessments. A rat perforation model of SAH was established, and MF was subsequently administered via intraperitoneal injection at a low and a high dose. High-dose MF significantly lowered the mortality of SAH animals and ameliorated their neurological deficits and brain edema. MF also dose-relatedly attenuated SAH-induced oxidative stress and decreased cortical cell apoptosis by influencing mitochondria-apoptotic proteins. In addition, MF downregulated the activation of the NLRP3 inflammasome and NF-κ B as well as the production of inflammatory cytokines, and the expression of Nrf2 and HO-1 was upregulated by MF. The abovementioned findings indicate that MF is neuroprotective against EBI after SAH and Nrf2/HO-1 cascade may play a key role in mediating its effect through regulation of the mitochondrial apoptosis pathway and activation of the NLRP3 inflammasome and NF-κ B.

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  • Mangiferin exerts neuroprotective effects against EBI by promoting the Nrf2/HO-1 cascade in the mitochondrial apoptosis pathway, as well as through NLRP3 inflammasome activation and NF-κB inhibition.

    “Mechanism analysis of mangiferin demonstrated that it exerts its neuroprotective effects against EBI by promoting the nuclear factor erythroid 2-related factor 2 (Nrf2)/HO-1 cascade in the mitochondrial apoptosis pathway, as well as through NLRP3 inflammasome activation and NF-κB inhibition (74).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [74]

    The Results (page not available) support mangiferin’s effects on mitochondrial apoptosis and NF-κB inhibition in rats with early brain injury after subarachnoid hemorrhage. But the NLRP3 Results state the opposite of the claim’s 'NLRP3 inflammasome activation': mangiferin inhibited its activation. (LLM, conf=0.92)

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  • Mangiferin decreases mortality of animals with SAH, ameliorates neurological deficits and brain edema, attenuates SAH-induced oxidative stress and decreases cortical cell apoptosis in a dose-dependent manner.

    “It was demonstrated that mangiferin decreases the mortality of animals with SAH, ameliorates neurological deficits and brain edema, attenuates SAH-induced oxidative stress and decreases cortical cell apoptosis in a dose-dependent manner.”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [74]

  • Mangiferin effectively protects against early brain injury involved in cerebral tissue damage induced by subarachnoid hemorrhage.

    “Furthermore, mangiferin effectively protects against early brain injury (EBI) that is involved in the process of cerebral tissue damage induced by subarachnoid hemorrhage (SAH) (74).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [74]

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Cited by

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Authors
Wang, Z., Guo, S., Wang, J., Shen, Y., Zhang, J., & Wu, Q.
Affiliations
Second Affiliated Hospital of Zhejiang University (CN)
Corresponding author
Wu, Qun
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-09-19
Volume
7
Issue
1
Pages
11883-11883
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-12160-6
PMC
PMC5605716
OpenAlex
W2754836087
Cited by
92
References
8
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 19 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 1 · 2016: 1
FWCI
6.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81671909)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords
mangiferin, subarachnoid hemorrhage, early brain injury, neuroprotection, Nrf2/HO-1 pathway, mitochondrial apoptosis, NLRP3 inflammasome, NF-κB, neuroinflammation, oxidative stress, cerebral edema, xanthones
MeSH terms
Animals, Brain Injuries, Heme Oxygenase (Decyclizing), Inflammation, Male, Mitochondria, Subarachnoid Hemorrhage, Rats, Sprague-Dawley, Apoptosis, Neuroprotective Agents, Xanthones, NF-E2-Related Factor 2, Rats

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