Cited by 235DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

The role of BRCA1 in DNA damage response

Open access

Wu, Jiaxue, Lu, Lin-Yu, Yu, Xiaochun·2010·Protein & Cell

DOI 10.1007/s13238-010-0010-5PMC PMC3078634

Open this paper in CoChat — free account Open PDF

Abstract

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s13238-010-0010-5

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544
Cell Cycle Control and Cancer
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Kuerbitz, S. J., Plunkett, B., Walsh, W., & Kastan, M. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7491 · Cited by 1,837
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Show all 100 references

Sorted by citations

Items 101–200 of 235

Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1
Hoch, D., Bachbauer, M., Pöchlauer, C., Algaba‐Chueca, F., Tandl, V., Novakovic, B., Megía, A., Gauster, M., Saffery, R., Glasner, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020468 · Cited by 18
High BRCA1 gene expression increases the risk of early distant metastasis in ER+ breast cancers
Ch’ang, H.-J., Yang, U., Lai, M., Chen, C., & Fann, Y. C. (2022) · Scientific Reports · doi:10.1038/s41598-021-03471-w · Cited by 17
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19
Loh, D., & Reiter, R. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158122 · Cited by 17
Role of the Nrf2/ARE Pathway in the mtDNA Reparation
Gureev, A. P., Chernyshova, E. V., Krutskikh, E. P., Sadovnikova, I. S., Tekutskaya, E. E., & Dorohova, A. A. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906218 · Cited by 15
Polyisoprenylated methylated protein methyl esterase overexpression and hyperactivity promotes lung cancer progression.
Amissah, F., Duverna, R., Aguilar, B. J., Poku, R. A., Kiros, G.-E., & Lamango, N. S. (2014) · Europe PMC (PubMed Central) · Cited by 15
Epigenetic Modifications in Ovarian Cancer: A Review
Ashraf, A. H. M. Z., Afroze, S. H., Osuji, G., Kayani, S., Colon, N., Pantho, A. F., Kuehl, T. J., Pilkinton, K. A., & Uddin, M. (2020) · Journal of Cancer Treatment and Diagnosis · doi:10.29245/2578-2967/2020/2.1179 · Cited by 15
Effects of radiotherapy and short-term starvation combination on metastatic and non-tumor cell lines
Pignatta, S., Cortesi, M., Arienti, C., Zanoni, M., Cocchi, C., Sarnelli, A., Arpa, D., Piccinini, F., & Tesei, A. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102949 · Cited by 15
Exposure to coal mining can lead to imbalanced levels of inorganic elements and DNA damage in individuals living near open-pit mining sites
León-Mejía, G., Vargas, J. E., Quintana-Sosa, M., Rueda, R. A., Pérez, J. P., Miranda-Guevara, A., Moreno, O. F., Trindade, C., Acosta-Hoyos, A. J., Dias, J. F., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115773 · Cited by 14
Bloom syndrome patients and mice display accelerated epigenetic aging
Lee, J., Zhang, J., Flanagan, M., Martínez-Agosto, J. A., Cunniff, C. M., Kucine, N., Lu, A. T.-H., Haghani, A., Gordevičius, J., Horvath, S., et al. (2023) · Aging Cell · doi:10.1111/acel.13964 · Cited by 13
CRISPR based therapeutic targeting of signaling pathways in breast cancer.
Misra, G., Qaisar, S., & Singh, P. (2023) · Biochimica et Biophysica Acta - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166872 · Cited by 11
Advances in breast cancer research using CRISPR/Cas9 system
Eskandari, F., Aali, M., Hadisadegh, S. N., & Azadeh, M. (2024) · Nano Select · doi:10.1002/nano.202400015 · Cited by 18
DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration
Sharma, H., Koirala, S., Chew, Y. L., & Konopka, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04331-0 · Cited by 14
Complex Interplay between DNA Damage and Autophagy in Disease and Therapy
Singh, A. D., Ravendranathan, N., Frisbee, J. C., & Singh, K. K. (2024) · Biomolecules · doi:10.3390/biom14080922 · Cited by 14
Dysregulation of miR-638 in the progression of cancers
Chong, Z. X., Yeap, S. K., & Ho, W. Y. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153351 · Cited by 14
In-Silico Analyses of Nonsynonymous Variants in the BRCA1 Gene
Arshad, S., Ishaque, I., Mumtaz, S., Rashid, M. U., & Malkani, N. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10074-7 · Cited by 14
Conducting polymers as a functional recognition interface to design sensors for pathogen and cancer diagnosis
Karasu, T., Armutçu, C., Elkhoury, K., Özgür, E., Maziz, A., & Uzun, L. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117705 · Cited by 13
Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases’ occurrence
Medimegh, I., Troudi, W., Stambouli, N., Khodjet‐El‐Khil, H., Baroudi, O., Ayari, H., Omrane, I., Uhrhammer, N. A., Privat, M., Mézlini, A., et al. (2014) · Medical Oncology · doi:10.1007/s12032-014-0255-6 · Cited by 13
A new genetically engineered mouse model of choroid plexus carcinoma
Nagar, S. E., Zindy, F., Moens, C., Martin, L., Plassard, D., Roussel, M. F., Lamonerie, T., & Billon, N. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.192 · Cited by 13
Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma
Wei, B., Han, Q. Y., Xu, L., Zhang, X., Zhu, J., Wan, L., Jin, Y., Qian, Z., Wu, J., Gao, Y., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1364-0 · Cited by 12
Self-citation
Loss of BRCA1-A Complex Function in RAP80 Null Tumor Cells
Bian, C., WU, R. T., Cho, K. R., & Yu, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040406 · Cited by 12
Self-citation
β-TrCP1 facilitates cell cycle checkpoint activation, DNA repair, and cell survival through ablation of β-TrCP2 in response to genotoxic stress
Islam, S., Dutta, P., Sahay, O., & Santra, M. K. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100511 · Cited by 12
DNA repair function scores for 2172 variants in the BRCA1 amino-terminus
Diabate, M., Islam, M. M., Nagy, G., Banerjee, T., Dhar, S., Smith, N. T., Adamovich, A. I., Starita, L. M., & Parvin, J. D. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010739 · Cited by 11
BRCA1 regulates transforming growth factor‐β (TGF‐β1) signaling through Gadd45a by enhancing the protein stability of Smad4
Li, D., Kang, N., Ji, J., & Zhan, Q. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.05.002 · Cited by 11
Clinical Benefit of Niraparib to TKI/mTORi-Resistance Metastatic ccRCC With BAP1-Frame Shift Mutation: Case Report and Literature Review
Lian, B., Zhang, K., Fang, X.-D., Li, F., Dai, Z., Chen, W., & Qi, X.-P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.927250 · Cited by 11
Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer
Prodosmo, A., Buffone, A., Mattioni, M., Barnabei, A., Persichetti, A., Leo, A. D., Appetecchia, M., Nicolussi, A., Coppa, A., Sciacchitano, S., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0410-3 · Cited by 11
Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome
Kota, S. K., Chowdhury, D. R., Rao, L. K., Padmalatha, V. V., Singh, L., & Bhadra, U. (2014) · Chromosoma · doi:10.1007/s00412-014-0495-4 · Cited by 10
Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats
García-Alegría, A. M., Gómez‐Álvarez, A., Anduro-Corona, I., Burgos‐Hernández, A., Ruíz-Bustos, E., Canett‐Romero, R., González‐Ríos, H., López‐Cervantes, J. G., Rodríguez-Martínez, K. L., & Astiazarán‐García, H. (2020) · Toxics · doi:10.3390/toxics8020031 · Cited by 10
Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies
Zhao, H., Shen, J., Wang, D., Gregory, S., Medico, L., Hu, Q., Yan, L., Odunsi, K. O., Lele, S., & Liu, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047962 · Cited by 10
Comprehensive analysis the prognostic and immune characteristics of mitochondrial transport-related gene SFXN1 in lung adenocarcinoma
Liu, W., Du, Q., Mei, T., Wang, J., Huang, D., & Qin, T. (2024) · BMC Cancer · doi:10.1186/s12885-023-11646-z · Cited by 9
Navigating the frontier: Comprehensive insights into CRISPR technology advancements, delivery strategies, and ethical considerations in cancer research
Jain, M. S., Srikruthi, K. S., Prakash Goudanavar, S. O. P., & Naveen, N. R. (2024) · Oral Oncology Reports · doi:10.1016/j.oor.2024.100224 · Cited by 10
Personalized prediction of genes with tumor-causing somatic mutations based on multi-modal deep Boltzmann machine
Li, Y., Fauteux, F., Zou, J., Nantel, A., & Pan, Y. (2018) · Neurocomputing · doi:10.1016/j.neucom.2018.02.096 · Cited by 9
Epigenetic factors in breast cancer therapy
Mathur, R., Jha, N. K., Saini, G., Jha, S. K., Shukla, S. P., Filipejová, Z., Kesari, K. K., Iqbal, D., Nand, P., Upadhye, V. J., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.886487 · Cited by 13
Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation
Yan, L., Wu, F., Jiao, J., Maimaiti, A., Li, Y., Shao, L., Liang, Q., Xiong, X., & Qin, Z. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s491473 · Cited by 8
Transcript profile distinguishes variability in human myogenic progenitor cell expansion capacity
Riddle, E. S., Bender, E. L., & Thalacker‐Mercer, A. E. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00041.2018 · Cited by 8
The Role of Genetic Mutations in Mitochondrial-Driven Cancer Growth in Selected Tumors: Breast and Gynecological Malignancies
Czegle, I., Huang, C., Soria, P., Purkiss, D., Shields, A., & Wappler-Guzzetta, E. A. (2023) · Life · doi:10.3390/life13040996 · Cited by 10
MicroRNA-199a-3p promotes drug sensitivity in triple negative breast cancer by down-regulation of BRCA1.
Ho, J. C.-W., Chen, J., Cheuk, I., Siu, M.-T., Shin, V. Y., & Kwong, A. (2022) · PubMed Central · Cited by 8
Riccardin D Exerts Its Antitumor Activity by Inducing DNA Damage in PC-3 Prostate Cancer Cells In Vitro and In Vivo
Hu, Z., Kong, F., Si, M., Tian, K., Yu, L. X., Young, C. Y. F., Yuan, H., & Lou, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074387 · Cited by 8
PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in mice
Bošnjak, M., Jesenko, T., Markelc, B., Janžič, L., Čemažar, M., & Serša, G. (2021) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2021.107832 · Cited by 8
Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Gursky, Z. H., Khan, Z. N., Koundal, S., Bhardwaj, A., Melgarejo, J. C., Xu, K., Chen, X., Lin, H., Gu, X., Lee, H., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci182555 · Cited by 7
Genome Assembly and Evolutionary Analysis of the Mandarin Duck Aix galericulata Reveal Strong Genome Conservation among Ducks
Ng, C. S., Lai, C., Ke, H., Lee, H., Chen, C., Tang, P., Cheng, H., Lu, M. J., Li, W., & Tsai, I. J. (2022) · Genome Biology and Evolution · doi:10.1093/gbe/evac083 · Cited by 7
BRCA1 transports the DNA damage signal for CDDP ‐induced centrosome amplification through the centrosomal Aurora A
Qi, H., Kikuchi, M., Yoshino, Y., Fang, Z., Ohashi, K., Gotoh, T., Ideta, R., Ui, A., Endo, S., Otsuka, K., et al. (2022) · Cancer Science · doi:10.1111/cas.15573 · Cited by 7
A transcriptomic study of ‘Granny Smith’ apple fruit response to x-ray irradiation using RNA-Seq
Atamian, H. S., Loayza, F. E., & Prakash, A. (2022) · Scientia Horticulturae · doi:10.1016/j.scienta.2022.111777 · Cited by 7
IRX5 promotes DNA damage repair and activation of hair follicle stem cells
Chen, J. K., Wiedemann, J., Nguyen, L. T. H., Lin, Z., Tahir, M., Hui, C., Plikus, M. V., & D, B. A. M. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.03.013 · Cited by 7
F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently to low-dose ionizing radiation exposure
Mukherjee, S., Sainis, K. B., & Deobagkar, D. D. (2014) · Journal of Genetics · doi:10.1007/s12041-014-0422-8 · Cited by 7
Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer—A Comprehensive Review of Literature
Kciuk, M., Wanke, K., Marciniak, B., Kołat, D., Aleksandrowicz, M., Mujwar, S., Ainane, T., & Kontek, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031152 · Cited by 7
FOXM1 affects oxidative stress, mitochondrial function, and the DNA damage response by regulating p21 in aging oocytes
Yu, W., Cai, X., Wang, C., Peng, X., Xu, L., Gao, Y., Tian, T., Zhu, G., Pan, Y., Chu, H., et al. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.08.010 · Cited by 6
Letrozole and zoledronic acid changed signalling pathways involved in the apoptosis of breast cancer cells
Sheweita, S. A., Ammar, R. G., Sabra, S. A., & Sultan, A. (2020) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2020.10.017 · Cited by 7
Multitumor Case Series of Germline BRCA1, BRCA2 and CHEK2-Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors
Kinget, L., Bechter, O. E., Punie, K., Debruyne, P. R., Brems, H., Clement, P., Roussel, E., Herck, Y. V., Albersen, M., Baldewijns, M. M. L. L., et al. (2021) · Current Oncology · doi:10.3390/curroncol28050280 · Cited by 8
Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers.
Rajan, A., Varghese, G. R., Yadev, I., Anandan, J., Latha, N. R., Patra, D., Krishnan, N., Kuppusamy, K., Warrier, A. V., Bhushan, S., et al. (2022) · PubMed Central · Cited by 6
BAG1, MGMT, FOXO1 , and DNAJA1 as potential drug targets for radiosensitizing cancer cell lines
Manunu, B., Serafin, A. M., & Akudugu, J. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2074164 · Cited by 6
Investigation of germline variants in Bahraini women with breast cancer using next-generation sequencing based-multigene panel
Al‐Kafaji, G., Jassim, G., Hajeri, A. A., Alawadhi, A. M. T., Fida, M., Şahin, İ., Alali, F., & Fadel, E. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291015 · Cited by 6
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update
Yan, L.-J., Lau, A. T. Y., & Xu, Y. (2024) · Epigenomics · doi:10.2217/epi-2023-0430 · Cited by 6
Association of genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 with the risk of endometrial carcinoma and clinicopathological parameters among Chinese Han women
Zheng, L., Song, A.-P., Chen, L., Liu, D., Li, X.-H., Guo, H., Tian, X., & Fang, W. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.11.001 · Cited by 6
Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability
Tarpey, M. D., Amorese, A. J., LaFave, E. R., Minchew, E. C., Fisher‐Wellman, K. H., McClung, J. M., Hvastkovs, E. G., & Spangenburg, E. E. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000265 · Cited by 5
Overexpression of CDC42 causes accumulation of DNA damage leading to failure of oogenesis in triploid Pacific oyster Crassostrea gigas
Yang, Q., Yu, H., Du, S., & Li, Q. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136769 · Cited by 5
The effects of novel point mutations in the BRCA1 protein structure of breast cancer patients with breast or ovarian familial cancer history: an in-silico study
Nabi‐Afjadi, M., Yaghoubzad-Maleki, M., Asl, F. S. S., Yazdanpour, M., Kachouei, F. A., & Baziyar, P. (2025) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-024-05961-y · Cited by 5
Functional coding and non-coding variants in human BRCA1 gene and their use in genetic screening
Tuncel, G., & Ergören, M. Ç. (2019) · Medical Oncology · doi:10.1007/s12032-019-1294-9 · Cited by 5
Genomic Instability and DNA Repair in Cancer
Das, B., Choudhury, B., Kumar, A. A., & Baruah, V. J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95736 · Cited by 5
ANKHD1 is an S phase protein required for histone synthesis and DNA repair in multiple myeloma cells
Dhyani, A., Favaro, P. M. B., & Saad, S. T. O. (2020) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2020.102460 · Cited by 5
DNA Damage Response and Repair Genes and Anthracycline-Induced Cardiomyopathy in Childhood Cancer Survivors: A Report From the Children’s Oncology Group and the Childhood Cancer Survivor Study
Wang, X., Singh, P., Cejas, R. B., Zhou, L., Sharafeldin, N., Trainor, P. J., Landier, W., Cheng, C., Hageman, L., Wang, F., et al. (2025) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.124.004813 · Cited by 4
Involvement of a coumarin analog AD-013 in the DNA damage response pathways in MCF-7 cells
Długosz-Pokorska, A., Drogosz-Stachowicz, J., Deredas, D., Janecki, T., & Janecka, A. E. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4271-z · Cited by 4
Establishing the role of BRCA1 in the diagnosis, prognosis and immune infiltrates of breast invasive cancer by bioinformatics analysis and experimental validation
Li, L., Li, S., Zhang, X., Mei, L., Fu, X., Dai, M., & Wei, N. (2024) · Aging · doi:10.18632/aging.205366 · Cited by 5
Distinct associations of the Saccharomyces cerevisiae Rad9 protein link Mac1-regulated transcription to DNA repair
Gkouskou, K. K., Fragiadakis, G. S., Voutsina, A., & Alexandraki, D. (2019) · Current Genetics · doi:10.1007/s00294-019-01047-w · Cited by 4
Correction: Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies
Zhao, H., Shen, J., Wang, D., Guo, Y., Gregory, S., Medico, L., Hu, Q., Li, Y., Odunsi, K. O., Lele, S., et al. (2013) · PLoS ONE · doi:10.1371/annotation/febad39e-58f0-4562-a687-1fee2a7d1eff · Cited by 4
Selenium-containing metallodrug overcomes cervical cancer radioresistance through physical–chemical dual sensitization
Cao, J., Guo, F., Jiang, H., Liu, C., Guo, J., Cai, F., Lin, H., Ma, L., & Chen, T. (2024) · Dalton Transactions · doi:10.1039/d4dt02643h · Cited by 3
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay
Sun, B., Li, Y., Wu, Y., Wang, C., Zhu, J., Zhang, W., Li, D., Que, W., & Chen, G. (2025) · Oncogenesis · doi:10.1038/s41389-025-00578-x · Cited by 3
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation
Yu, Z., Peng, W., Li, M., Li, F., Zhang, T., Nong, Y., Liu, C., Liu, W., Ding, H., Lv, X., et al. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000004655 · Cited by 3
Research Progress of BAP1 in Structure, Function, and Cancer
Lu, W.-T., Li, M.-R., Yang, Y., Sun, Y., & Dong, C.-M. (2023) · Protein and Peptide Letters · doi:10.2174/0929866530666230526143710 · Cited by 3
Immunogenomics of Metastatic Clear-Cell Renal Cell Carcinoma: Remarkable Response to Nivolumab in a Patient With a Pathogenic Germ Line BRCA1 Mutation
Beulque, Y., Deleu, A.-L., Punie, K., Wever, L. D., Baldewijns, M. M. L. L., Caruso, S., Couchy, G., Zucman‐Rossi, J., & Beuselinck, B. (2019) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2019.06.013 · Cited by 3
Sequencing of BRCA1/2-alterations using NGS-based technology: annotation as a challenge
Ebner, S., Winkelmann, R., Martin, S., Köllermann, J. W., Wild, P. J., & Demes, M. C. (2022) · Oncotarget · doi:10.18632/oncotarget.28213 · Cited by 3
Cell-type-specific epigenomic variations associated with BRCA1 mutation in pre-cancer human breast tissues
Hsieh, Y.-P., Naler, L. B., Ma, S., & Lu, C. (2022) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqac006 · Cited by 3
Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis
He, W., Zhu, H., Zhang, S., Shu, G., Lei, H., Yin, G., Ni, X., Wang, M., & Wu, Q. (2024) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5105109 · Cited by 3
Gene Expression Analysis Approach to Establish Possible Links Between Parkinson's Disease, Cancer and Cardiovascular Diseases
Karim, S., Mirza, Z., Kamal, M. A., Abuzenadah, A. M., & Al-Qahtani, M. H. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141023122803 · Cited by 3
Systems Pharmacodynamic Model of Combined Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
Miao, X., Koch, G., Shen, S., Wang, X., Li, J., Shen, X., Qu, J., Straubinger, R. M., & Jusko, W. J. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.10.036 · Cited by 3
Realizing the Potential of Protein-Protein Interaction Prediction for Studying Single and Evolutionarily Similar Organisms and Engineering Inhibitory Proteins with InSiPS: The In Silico Protein Synthesizer
Schoenrock, A. (2016) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2016-11283 · Cited by 3
Disentangling the aging network of a termite queenPreprint
Kuhn, J. M. M., Meusemann, K., & Korb, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.19.423576 · Cited by 3
Triple-Action Therapy: Combining Machine Learning, Docking, and Dynamics to Combat BRCA1-Mutated Breast Cancer
Zainulabidin, A. A., Sufyan, A. J., & Thirunavukkarasu, M. K. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01328-x · Cited by 2
The pyrrolizidine alkaloid lasiocarpine impairs cell cycle progression in vitro
Hessel‐Pras, S., Beckschulte, M., Peters, A., Koellner, A., Rosskopp, B., Stahl, A., Templin, M. F., Sprenger, H., Böhmert, L., Kuepper, J.-H., et al. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04185-y · Cited by 2
Ubiquitin Signaling in Ovarian Cancer: From Potential to Challenges
Mitra, S. (2018) · InTech eBooks · doi:10.5772/intechopen.75485 · Cited by 2
Dry tobacco leaves: anin vivoandin silicoapproach to the consequences of occupational exposure
Dalberto, D., Garcia, A. L. H., de Souza, M. R., Picinini, J., Soares, S., de Souza, G. M. S., Chytry, P., Dias, J. F., Salvador, M. M., da Silva, F. R., et al. (2023) · Mutagenesis · doi:10.1093/mutage/gead003 · Cited by 2
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
Lu, M., Gao, Q. S., Jin, R., Gu, M., Wang, Z., Li, X., Li, W., Wang, J., & Ma, T. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00941-x · Cited by 2
DNA damage and repair in patients undergoing myocardial perfusion single-photon emission computed tomography
Lorenzo, A. D., Fernandes, M. C. D. S., Romeiro, F., Botelho, A. P. A., & Dias, G. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-63537-3 · Cited by 2
Intertumoral heterogeneity of the immune microenvironment in high grade canine mast cell tumors
Bardales, K., Jiang, L., Radaelli, E., Assenmacher, C., Lenz, J., & Atherton, M. J. (2025) · Veterinary oncology. · doi:10.1186/s44356-025-00020-9 · Cited by 2
Domain-Specific DNA Binding Activities of BRCA1 Reveal Substrate Preferences for Homologous Recombination and Telomere Regulation
Lowran, K., Campbell, L., Cismas, E., & Wu, C. G. (2025) · Biochemistry · doi:10.1021/acs.biochem.5c00333 · Cited by 2
BCR-ABL Hits at Mitosis; Implications for Chromosomal Instability, Aneuploidy and Therapeutic Strategy
Piwocka, K., Wolanin, K., Kusio-Kobiałka, M., & Podszywalow‐Bartnicka, P. (2011) · InTech eBooks · doi:10.5772/25780 · Cited by 2
Changes in the Proteome Profile of A549 Cells Following Helichrysetin-Induced Apoptosis Suggest the Involvement of DNA Damage Response and Cell Cycle Arrest-Associated Proteins
Ho, Y. F., Yajit, N. L. M., Shiau, J., Malek, S. N. A., Shyur, L., & Karsani, S. A. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04384-2 · Cited by 2
Computational drug Cumintrazole-analog for the treatment of mutant BRCA1 and BRCA2 proteins in breast cancer
Baseer, S., Khan, S. A., & Nouroz, F. (2015) · International Current Pharmaceutical Journal · doi:10.3329/icpj.v4i8.24021 · Cited by 2
Core Homologous Recombination Mutations and Improved Survival in Nonpancreatic GI Cancers
Tan, E., Whiting, J., Knepper, T., Xie, H., Imanirad, I., Carballido, E., Felder, S. I., Frakes, J., Mo, Q., Permuth, J. B., et al. (2022) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000901 · Cited by 1
Targeting mammalian N-end rule pathway for cancer therapy
Mattoo, S., Arora, M., Sharma, P., & Pore, S. K. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116684 · Cited by 1
Eukaryote DNA Replication and Recombination: an Intimate Association
Ramsay, J., Al-Zeer, K., & Jacob, Z. (2011) · InTech eBooks · doi:10.5772/19995 · Cited by 1
BRCA1 and BRCA2 Testing in Inherited Breast Cancer
Bowles, K. R., & Rosenthal, E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8127-0_10 · Cited by 1
Innovative strategies to overcome cancer drug resistance: from nanodelivery systems to targeted therapeutics
Rejili, M., Farahani, N., Alimohammadi, M., & Hushmandi, K. (2026) · Discover Oncology · doi:10.1007/s12672-026-05260-1 · Cited by 1
Radiation-Induced Colitis in a Pancreatic Cancer Patient With a Germline BRCA2 Mutation: A Case Report
Wolfe, A. R., Jain, R., Pawlik, T. M., Walker, J. P., & Williams, T. M. (2018) · Advances in Radiation Oncology · doi:10.1016/j.adro.2018.08.025 · Cited by 1
An in silico analysis of genome-wide expression profiles of the effects of exhaustive exercise identifies heat shock proteins as the key players
Orozco, C. A., González‐Giraldo, Y., Bonilla, D. A., & Forero, D. A. (2022) · Meta Gene · doi:10.1016/j.mgene.2022.101012 · Cited by 1
Therapeutic Options in BRCA1-Linked Breast Cancer and Systemic Approaches
Khan, A. S., Jan, A., & Fatmi, M. Q. (2022) · Springer eBooks · doi:10.1007/978-981-19-0197-3_12 · Cited by 1
Validation of a Gene-Expression Based Assay for BRCA1 Function
Uy, P. (2013) · QSpace (Queen's University Library) · Cited by 1
The Genetics of Pancreatic Cancer
Dagan, E., & Gershoni‐Baruch, R. (2012) · InTech eBooks · doi:10.5772/29751
[BRCA1: a new predictive genomic marker for chemotherapy and radiotherapy of non-small cell lung cancer].
Li, M., & Fan, S. (2012) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2012.08.06
Investigação do papel de SNVs (single nucleotide variants) na etiologia da fissura lábio-palatina não sindrômica
Silva, C. M. A. D. C. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2013.tde-23072013-140648
Molecular basis of gynecological oncology – TopBP1 protein as the guardian of genome integrity
Forma, E., Wójcik‐Krowiranda, K., Bieńkiewicz, A., & Bryś, M. (2013) · Ginekologia Polska · doi:10.17772/gp/1592

Authors: Wu, J., Lu, L.-Y., & Yu, X.
Affiliations: University of Michigan (US)
Corresponding author: Yu, Xiaochun
ORCID: Wu, Jiaxue
Lu, Lin-Yu
Yu, Xiaochun
Venue: Protein & Cell
Publisher: Oxford University Press (OUP)
Published: 2010-02
Volume: 1
Issue: 2
Pages: 117-123
ISSN: 1674-800X (ISSN-L)
1674-8018
DOI: 10.1007/s13238-010-0010-5
PMC: PMC3078634
OpenAlex: W2140930673
Cited by: 235
References: 100
Citations by year: 2026: 5 · 2025: 13 · 2024: 25 · 2023: 17 · 2022: 32 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
FWCI: 0.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Protein & Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Michigan
National Institutes of Health
National Cancer Institute (R01CA132755, R01CA130899, CA132755)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, DNA damage response, tumor suppression, DNA repair, genome stability, ubiquitination, chromatin remodeling, transcriptional regulation, apoptosis, breast cancer, ovarian cancer
MeSH terms: Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Ovarian Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Genes, cdc, BRCA1 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of BRCA1 in DNA damage response

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks