The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
The role of BRCA1 in DNA damage response
Open accessAbstract
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
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“Evidence suggests that BRCA1 could be one of the key players in DNA damage response [281].”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [281]
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Cites
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Alhegaili, A. S. (2016) · Figshare
The Ras effector NORE1A forms a tumor suppressor complex with BRCA1.
Nelson, N. C. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2336
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Novel Aminoglycoside Polymers and Combination Treatments in Triple Negative Breast Cancer Studies
Muralikrishnan, H. (2018)
A mini review on role of brca1 in breast cancer
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BAP1, BIOMARCADOR DE PROGNÓSTICO EM GLIOBLASTOMA?
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Pathogenic BRCA1 DBD variants exhibit altered DNA binding affinities and susceptibility to menadionePreprint
Cismas, E., Lowry, E., Salib, V., Lowran, K., & Wu, C. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.10.664210
Genuardi, M., D’Ambrosio, P., & Sonnini, E. (2025) · Medizinische Genetik · doi:10.1515/medgen-2025-2038 · Cited by 1
The genetic basis of breast cancer
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Conserved Master Regulators Orchestrate Cellular Reprogramming-Induced RejuvenationPreprint
Yücel, A. D., Stevens, H. P., Tyshkovskiy, A., & Gladyshev, V. N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.27.690899
Additional file 3 of Disentangling the aging gene expression network of termite queens
Monroy-Kuhn, J. M., Meusemann, K., & Korb, J. (2021) · Figshare · doi:10.6084/m9.figshare.14576490
Liu, W., Du, Q., Mei, T., Wang, J., Huang, D., & Qin, T. (2024) · Figshare · doi:10.6084/m9.figshare.25017829
Additional file 1 of Disentangling the aging gene expression network of termite queens
Monroy-Kuhn, J. M., Meusemann, K., & Korb, J. (2021) · Figshare · doi:10.6084/m9.figshare.14576484
Domain-specific Analysis of BRCA1 Variants Revealed Enrichment of G → T and C → A TransversionsPreprint
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Pemetrexed increases BRCA1 protein stability and sensitizes TNBC cells to radiotherapy
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Metadata
- Authors
- Wu, J., Lu, L.-Y., & Yu, X.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Yu, Xiaochun
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 1
- Issue
- 2
- Pages
- 117-123
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- PMC
- PMC3078634
- OpenAlex
- W2140930673
- Cited by
- 235
- References
- 100
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 25 · 2023: 17 · 2022: 32 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Protein & Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health
- National Cancer Institute (R01CA132755, R01CA130899, CA132755)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, DNA damage response, tumor suppression, DNA repair, genome stability, ubiquitination, chromatin remodeling, transcriptional regulation, apoptosis, breast cancer, ovarian cancer
- MeSH terms
- Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Ovarian Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Genes, cdc, BRCA1 Protein
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