The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells
Open accessAbstract
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged as important tools for tissue engineering due to their differentiation potential along various cell types. In recent years, accumulating evidence has suggested that the regulation of mitochondria dynamics and function is essential for successful differentiation of MSCs. In this paper, we review and provide an integrated view on the role of mitochondria in MSC differentiation. The mitochondria are maintained at a relatively low activity level in MSCs, and upon induction, mtDNA copy number, protein levels of respiratory enzymes, the oxygen consumption rate, mRNA levels of mitochondrial biogenesis-associated genes, and intracellular ATP content are increased. The regulated level of mitochondrial ROS is found not only to influence differentiation but also to contribute to the direction determination of differentiation. Understanding the roles of mitochondrial dynamics during MSC differentiation will facilitate the optimization of differentiation protocols by adjusting biochemical properties, such as energy production or the redox status of stem cells, and ultimately, benefit the development of new pharmacologic strategies in regenerative medicine.
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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
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PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
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Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 759
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Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
Tormos, K. V., Anso, E., Hamanaka, R. B., Eisenbart, J., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 663
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Cited by
Yan, W., Diao, S., & Fan, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02194-z · Cited by 167
Human cells with osteogenic potential in bone tissue research
Dvorakova, J., Wiesnerova, L., Chocholata, P., Kulda, V., Landsmann, L., Cedikova, M., Kripnerova, M., Eberlova, L., & Babuska, V. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-023-01096-w · Cited by 58
Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control
Mukkala, A. N., Jerkic, M., Khan, Z., Szaszi, K., Kapus, A., & Rotstein, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115788 · Cited by 45
Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites
Wu, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020697 · Cited by 29
Nrf2 signaling pathway: focus on oxidative stress in osteoporosis
Gu, H.-Y., Liu, N., Lin, F.-X., & Yin, J. (2025) · Osteoporosis International · doi:10.1007/s00198-025-07592-0 · Cited by 10
Metadata
- Authors
- Li, Q., Gao, Z., Chen, Y., & Guan, M.-X.
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-07
- Volume
- 8
- Issue
- 6
- Pages
- 439-445
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- OpenAlex
- W2592262247
- Cited by
- 355
- References
- 46
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Q., Gao, Z., Chen, Y., & Guan, M.-X. (2017). The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein & Cell. https://doi.org/10.1007/s13238-017-0385-7
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