The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effects of Oxidative Stress on Mesenchymal Stem Cell Biology
Open accessAbstract
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and immune modulation, but their full clinical potential is far from realization. Here we review the role of oxidative stress in MSC biology, as their longevity and functions are affected by oxidative stress. In general, increased reactive oxygen species (ROS) inhibit MSC proliferation, increase senescence, enhance adipogenic but reduce osteogenic differentiation, and inhibit MSC immunomodulation. Furthermore, aging, senescence, and oxidative stress reduce their ex vivo expansion, which is critical for their clinical applications. Modulation of sirtuin expression and activity may represent a method to reduce oxidative stress in MSCs. These findings have important implications in the clinical utility of MSCs for degenerative and immunological based conditions. Further study of oxidative stress in MSCs is imperative in order to enhance MSC ex vivo expansion and in vivo engraftment, function, and longevity.
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Cites
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Cited by
Yan, W., Diao, S., & Fan, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02194-z · Cited by 167
Banihani, S. A. (2018) · Biomolecules · doi:10.3390/biom8040119 · Cited by 92
Facchin, F., Bianconi, E., Romano, M., Impellizzeri, A., Alviano, F., Maioli, M., Canaider, S., & Ventura, C. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.27181 · Cited by 46
Testosterone in Males as Enhanced by Onion (Allium Cepa L.)
Banihani, S. A. (2019) · Biomolecules · doi:10.3390/biom9020075 · Cited by 41
Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis
Redondo, J., Sarkar, P., Kemp, K., Heesom, K. J., Wilkins, A., Scolding, N. J., & Rice, C. M. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0045 · Cited by 37
Metadata
- Authors
- Denu, R. A., & Hematti, P.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 2016
- Issue
- 1
- Pages
- 2989076-2989076
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2433697453
- Cited by
- 333
- References
- 34
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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