The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The role of the gut microbiome and its metabolites in metabolic diseases
Open accessAbstract
It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease and so on. Numerous microorganisms dwell in the gastrointestinal tract, which is a key interface for energy acquisition and can metabolize dietary nutrients into many bioactive substances, thus acting as a link between the gut microbiome and its host. The gut microbiome is shaped by host genetics, immune responses and dietary factors. The metabolic and immune potential of the gut microbiome determines its significance in host health and diseases. Therefore, targeting the gut microbiome and relevant metabolic pathways would be effective therapeutic treatments for many metabolic diseases in the near future. This review will summarize information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases. Furthermore, recent advances in improving metabolic diseases by regulating the gut microbiome will be discussed.
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Citations
Cites
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Cited by
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
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Human gut microbiota in health and disease: Unveiling the relationship
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“Also, BBR can significantly increasing the abundance of bacteria such as phylum Verrucomicrobia, especially A.muciniphila.”
Background
Metadata
- Authors
- Wu, J., Wang, K., Wang, X., Pang, Y., & Jiang, C.
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-12-21
- Volume
- 12
- Issue
- 5
- Pages
- 360-373
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- OpenAlex
- W3117428187
- Cited by
- 557
- References
- 46
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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