Cited by 94Gut microbiota and healthDrug Transport and Resistance MechanismsSteroid Chemistry and Biochemistry

The 7-α-dehydroxylation pathway: an integral component of gut bacterial bile acid metabolism and potential therapeutic target

Open access
Wise, Journey L., Cummings, Bethany P.·2023·Frontiers in Microbiology

Abstract

The gut microbiome plays a significant role in maintaining host metabolic health through the production of metabolites. Comprising one of the most abundant and diverse forms of gut metabolites, bile acids play a key role in blood glucose regulation, insulin sensitivity, obesity, and energy expenditure. A central pathway in gut bacterial bile acid metabolism is the production of secondary bile acids via 7-ɑ-dehydroxylation. Despite the important role of 7-ɑ-dehydroxylation in gut bacterial bile acid metabolism and the pathophysiology of metabolic disease, the regulation of this pathway is not completely understood. This review aims to outline our current understanding of 7-ɑ-dehydroxylation and to identify key knowledge gaps that will be integral in further characterizing gut bacterial bile acid metabolism as a potential therapeutic target for treating metabolic dysregulation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fmicb.2022.1093420

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The probiotic mixture does not display 7α-dehydroxylation activity and therefore does not contribute to accumulation of potentially detrimental BA.

    “supporting that the probiotic mixture do not display 7α-dehydroxylation activity41 and therefore do not contribute to accumulation of potentially detrimental BA.42”

    From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [41]

    Citation 42 is attached to the conclusion about bile-acid accumulation, not to the mixture’s lack of activity, which is cited to 41. The Introduction (Overview; no page supplied) explains that 7α-dehydroxylation produces secondary bile acids, supporting the mechanistic link. It does not establish that this probiotic mixture avoids their accumulation or characterize those acids as potentially detrimental. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wise, J. L., & Cummings, B. P.
Affiliations
  • Cornell University (US)
  • University of California Davis Medical Center (US)
Corresponding author
Cummings, Bethany P.
Venue
Frontiers in Microbiology
Published
2023-01-09
Volume
13
Pages
1093420-1093420
ISSN
1664-302X (ISSN-L)
OpenAlex
W4313889929
Cited by
94
References
52
Citations by year
2026: 40 · 2025: 31 · 2024: 17 · 2023: 6
FWCI
2.47
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020541)
  • National Center for Complementary and Integrative Health (R21AT010956)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
gut microbiota, bile acid metabolism, secondary bile acids, bile acid synthesis, metabolic disorders, therapeutic target, host-microbe interactions, insulin sensitivity, obesity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review