The 7-α-dehydroxylation pathway: an integral component of gut bacterial bile acid metabolism and potential therapeutic target
Open accessAbstract
The gut microbiome plays a significant role in maintaining host metabolic health through the production of metabolites. Comprising one of the most abundant and diverse forms of gut metabolites, bile acids play a key role in blood glucose regulation, insulin sensitivity, obesity, and energy expenditure. A central pathway in gut bacterial bile acid metabolism is the production of secondary bile acids via 7-ɑ-dehydroxylation. Despite the important role of 7-ɑ-dehydroxylation in gut bacterial bile acid metabolism and the pathophysiology of metabolic disease, the regulation of this pathway is not completely understood. This review aims to outline our current understanding of 7-ɑ-dehydroxylation and to identify key knowledge gaps that will be integral in further characterizing gut bacterial bile acid metabolism as a potential therapeutic target for treating metabolic dysregulation.
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The probiotic mixture does not display 7α-dehydroxylation activity and therefore does not contribute to accumulation of potentially detrimental BA.
“supporting that the probiotic mixture do not display 7α-dehydroxylation activity41 and therefore do not contribute to accumulation of potentially detrimental BA.42”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [41]
Citation 42 is attached to the conclusion about bile-acid accumulation, not to the mixture’s lack of activity, which is cited to 41. The Introduction (Overview; no page supplied) explains that 7α-dehydroxylation produces secondary bile acids, supporting the mechanistic link. It does not establish that this probiotic mixture avoids their accumulation or characterize those acids as potentially detrimental. (LLM, conf=0.78)
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- Authors
- Wise, J. L., & Cummings, B. P.
- Affiliations
- Cornell University (US)
- University of California Davis Medical Center (US)
- Corresponding author
- Cummings, Bethany P.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2023-01-09
- Volume
- 13
- Pages
- 1093420-1093420
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC9868651
- OpenAlex
- W4313889929
- Cited by
- 94
- References
- 52
- Citations by year
- 2026: 40 · 2025: 31 · 2024: 17 · 2023: 6
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020541)
- National Center for Complementary and Integrative Health (R21AT010956)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- gut microbiota, bile acid metabolism, secondary bile acids, bile acid synthesis, metabolic disorders, therapeutic target, host-microbe interactions, insulin sensitivity, obesity
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