Steroids, stress and the gut microbiome-brain axis
Open accessAbstract
It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how perturbations in the gut microbiota can alter the stress axis and behaviour. In addition, human studies on the possible role of gut microbiota in depression and anxiety are examined. Finally, we present some of the challenges and important questions that need to be addressed by future research in this exciting new area at the intersection of steroids, stress, gut-brain axis and human health.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The brain can affect intestinal function and the GM, for example, by HPA axis-mediated glucocorticoid modification of immunity in response to stress.
“Conversely, the brain can affect intestinal function and the GM, for example, by HPA axis-mediated glucocorticoid modification of immunity in response to stress (29).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [29]
Cortisol receptors are expressed on various cells of the gut, including epithelial cells, immune cells, and enteroendocrine cells, indicating a direct effect of cortisol on gut function.
“Cortisol receptors are expressed on various cells of the gut, including epithelial cells, immune cells, and enteroendocrine cells, indicating a direct effect of cortisol on gut function (21, 29, 48).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
Population-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165 · see citing works
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055 · see citing works
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Self-citationPopulation-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Generation and reproductive phenotypes of mice lacking estrogen receptor β
Krege, J. H., Hodgin, J. B., Couse, J. F., Enmark, E., Warner, M. N., Mahler, J. F., Sar, M., Korach, K. S., Gustafsson, J.-Α., & Smithies, O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15677 · Cited by 1,692 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Phage therapy: An alternative to antibiotics in the age of multi-drug resistance
Lin, D. M., Koskella, B. L., & Lin, H. C. (2017) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v8.i3.162 · Cited by 1,163 · see citing works
Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159 · see citing works
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
Self-citationAdams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Self-citationCorrelation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
Gut microbes and the brain: paradigm shift in neuroscience
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3299-14.2014 · Cited by 1,033 · see citing works
The vocabulary of microbiome research: a proposal
Marchesi, J., & Ravel, J. (2015) · Microbiome · doi:10.1186/s40168-015-0094-5 · Cited by 1,016 · see citing works
Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
The microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990 · see citing works
Self-citationPyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977 · see citing works
Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., Windey, K., Tremaroli, V., Bäckhed, F., Verbeke, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415174111 · Cited by 972 · see citing works
Gender Bias in Autoimmunity Is Influenced by Microbiota
Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 912 · see citing works
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works
Hill‐Burns, E. M., Debelius, J. W., Morton, J. T., Wissemann, W. T., Lewis, M. R., Wallen, Z. D., Peddada, S. D., Factor, S. A., Molho, E., Zabetian, C. P., et al. (2017) · Movement Disorders · doi:10.1002/mds.26942 · Cited by 874 · see citing works
Microbiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Sex differences and hormonal effects on gut microbiota composition in mice
Org, E., Mehrabian, M., Parks, B. W., Shipkova, P., Liu, X., Drake, T. A., & Lusis, A. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1203502 · Cited by 796 · see citing works
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742 · see citing works
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671 · cited 1× · see citing works
“Some studies report modest to no effects of sex on the human gut microbiota (30, 31), while other findings reveal substantial sex differences (32).”
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · cited 1× · see citing works
“Steenbergen and colleagues (100) showed that a multispecies probiotic reduced negative thoughts associated with sad mood, which the authors suggest supports the concept of probiotics intervention as a preventive approach for depression (100).”
Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655 · see citing works
Insights into the role of the microbiome in obesity and type 2 diabetes
Hartstra, A. V., Bouter, K. E. C., Bäckhed, F., & Nieuwdorp, M. (2015) · Diabetes Care · doi:10.2337/dc14-0769 · Cited by 641 · see citing works
Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-6 · Cited by 577 · see citing works
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works
Microbiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works
Sex, body mass index, and dietary fiber intake influence the human gut microbiome
Dominianni, C., Sinha, R., Goedert, J. J., Pei, Z., Yang, L., Hayes, R. B., & Ahn, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124599 · Cited by 468 · see citing works
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417 · see citing works
Lyte, M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003726 · Cited by 399 · see citing works
Goedert, J. J., Jones, G., Hua, X., Xu, X., Yu, G., Flores, R., Falk, R. T., Gail, M. H., Shi, J., Ravel, J., et al. (2015) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djv147 · Cited by 393 · see citing works
The gut microbiome and diet in psychiatry: focus on depression
Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000117 · Cited by 369 · see citing works
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 362 · see citing works
Fuhrman, B. J., Feigelson, H. S., Flores, R., Gail, M. H., Xu, X., Ravel, J., & Goedert, J. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2222 · Cited by 339 · see citing works
The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential
Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329 · see citing works
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model
Brandscheid, C., Schuck, F., Reinhardt, S., Schäfer, K.-H., Pietrzik, C. U., Grimm, M., Hartmann, T., Schwiertz, A., & Endres, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160926 · Cited by 318 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
Sex differences in the gut microbiome–brain axis across the lifespan
Jašarević, E., Morrison, K. E., & Bale, T. L. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0122 · Cited by 295 · see citing works
The microbiota–gut–brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
Palma, G. D., Collins, S. M., Berčík, P., & Verdu, E. F. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.273995 · Cited by 293 · see citing works
Altered colonic function and microbiota profile in a mouse model of chronic depression
Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works
Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice
Liu, Y.-W., Liu, W., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S. Z., & Tsai, Y.-C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.018 · Cited by 290 · see citing works
Mayer, E. A., Labus, J. S., Tillisch, K., Cole, S. W., & Baldi, P. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.121 · Cited by 282 · see citing works
Pirbaglou, M., Katz, J., de Souza, R. J., Stearns, J. C., Motamed, M., & Ritvo, P. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.06.009 · Cited by 270 · see citing works
The gut microbiota: A treasure for human health
Li, D., Wang, P., Wang, P., Hu, X., & Chen, F. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.08.003 · Cited by 265 · see citing works
The Gut Microbiome: A New Frontier in Autism Research
Mulle, J. G., Sharp, W. G., & Cubells, J. F. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-012-0337-0 · Cited by 262 · see citing works
Cani, P. D., Delzenne, N. M., Amar, J., & Burcelin, R. (2008) · Pathologie Biologie · doi:10.1016/j.patbio.2007.09.008 · Cited by 262 · see citing works
The microbiota in inflammatory bowel disease
Sheehan, D., Moran, C. P., & Shanahan, F. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1064-1 · Cited by 249 · see citing works
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.8.1050 · Cited by 237 · see citing works
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 225 · see citing works
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Intestinal Epithelium in Inflammatory Bowel Disease
Coskun, M. (2014) · Frontiers in Medicine · doi:10.3389/fmed.2014.00024 · Cited by 197 · see citing works
The gut microbiota and Type 1 Diabetes
Gülden, E., Wong, F. S., & Li, W. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.013 · Cited by 165 · see citing works
Bacterial Signaling to the Nervous System through Toxins and Metabolites
Yang, N. J., & Chiu, I. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.12.023 · Cited by 165 · see citing works
Davis, D. J., Doerr, H. M., Grzelak, A. K., Busi, S. B., Jašarević, E., Ericsson, A. C., & Bryda, E. C. (2016) · Scientific Reports · doi:10.1038/srep33726 · Cited by 162 · see citing works
Human Metabolic Phenotypes Link Directly to Specific Dietary Preferences in Healthy Individuals
Rezzi, S., Ramadan, Z., Martin, F., Fay, L. B., van Bladeren, P., Lindon, J. C., Nicholson, J. K., & Kochhar, S. (2007) · Journal of Proteome Research · doi:10.1021/pr070431h · Cited by 161 · see citing works
Javurek, A. B., Spollen, W. G., Johnson, S. A., Bivens, N. J., Bromert, K. H., Givan, S. A., & Rosenfeld, C. S. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1234657 · Cited by 160 · see citing works
Inoue, R., Sakaue, Y., Sawai, C., Sawai, T., Ozeki, M., Romero-Pérez, G. A., & Tsukahara, T. (2016) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2016.1222267 · Cited by 148 · see citing works
Menon, R., Watson, S. E., Thomas, L. N., Allred, C. D., Dabney, A. R., Azcárate-Peril, M. A., & Sturino, J. M. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01182-13 · Cited by 146 · see citing works
The normal intestinal microbiota
Marchesi, J. R., & Shanahan, F. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3282a56a99 · Cited by 136 · see citing works
More than a gut feeling: the microbiota regulates neurodevelopment and behavior
Cryan, J. F., & Dinan, T. G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.224 · Cited by 124 · see citing works
Intestinal microbiota and allergic diseases: A systematic review
Melli, L. C. F. L., do Carmo-Rodrigues, M. S., Araújo-Filho, H. B., Solé, D., & de Morais, M. B. (2016) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2015.01.013 · Cited by 110 · see citing works
Dinan, T. G., & Scott, L. V. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00443.x · Cited by 110 · see citing works
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108 · see citing works
Moreno‐Indias, I., Sánchez‐Alcoholado, L., Sanchez-Garrido, M. A., Martín‐Núñez, G. M., Pérez‐Jiménez, F., Tena‐Sempere, M., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2016) · Endocrinology · doi:10.1210/en.2016-1317 · Cited by 98 · see citing works
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8859 · Cited by 95 · see citing works
Melcangi, R. C., Giatti, S., & García‐Segura, L. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.023 · Cited by 94 · see citing works
Self-citationLim, J. S., Lim, M. Y., Choi, Y., & Ko, G. (2017) · Molecular Brain · doi:10.1186/s13041-017-0292-0 · Cited by 85 · see citing works
The Human Gut Microbiome and Its Dysfunctions
Mondot, S., de Wouters, T., Dore, J. M., & Lepage, P. (2013) · Digestive Diseases · doi:10.1159/000354678 · Cited by 84 · see citing works
Cox‐York, K. A., Sheflin, A. M., Foster, M. T., Gentile, C. L., Kahl, A., Koch, L. G., Britton, S. L., & Weir, T. L. (2015) · Physiological Reports · doi:10.14814/phy2.12488 · Cited by 84 · see citing works
Butyrate-induced GPR41 Activation Inhibits Histone Acetylation and Cell Growth
Wu, J., Zhou, Z., Hu, Y., & Dong, S. (2012) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2012.05.008 · Cited by 80 · see citing works
Neuroactive steroids, their metabolites, and neuroinflammation
Giatti, S., Boraso, M., Melcangi, R. C., & Viviani, B. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0127 · Cited by 79 · see citing works
Self-citationContributions of estrogen receptor-α and estrogen receptor-β to the regulation of behavior
Tetel, M. J., & Pfaff, D. W. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.01.008 · Cited by 68 · see citing works
Self-citationGut microbiota, 1013 new pieces in the Parkinson's disease puzzle
Scheperjans, F. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000389 · Cited by 63 · see citing works
Neuroactive steroids and the peripheral nervous system: An update
Giatti, S., Romano, S., Pesaresi, M., Cermenati, G., Mitro, N., Caruso, D., Tetel, M. J., García‐Segura, L. M., & Melcangi, R. C. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.014 · Cited by 50 · see citing works
Self-citationThe microbiome and childhood diseases: Focus on brain‐gut axis
O’Mahony, S. M., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21118 · Cited by 50 · see citing works
Self-citationBrain inflammasomes in stroke and depressive disorders: Regulation by oestrogen
Slowik, A., Lammerding, L., Hoffmann, S., & Beyer, C. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12482 · Cited by 49 · see citing works
Bacterial colonization and intestinal mucosal barrier development
Huang, X. (2013) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v2.i4.46 · Cited by 48 · see citing works
The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions
Vasconcelos, A. R., Cabral‐Costa, J. V., Mazucanti, C. H., Scavone, C., & Kawamoto, E. M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00009 · Cited by 41 · see citing works
Association of the Intestinal Microbiota and Obesity.
Lopez‐Cepero, A. A., & Palacios, C. S. (2015) · PubMed · Cited by 35 · see citing works
Vasopressin deletion is associated with sex-specific shifts in the gut microbiome
Fields, C. T., Chassaing, B., Paul, M. J., Gewirtz, A. T., & Vries, G. J. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1356557 · Cited by 30 · see citing works
Breathing Better Through Bugs: Asthma and the Microbiome.
Adami, A. J., & Bracken, S. J. (2016) · PubMed Central · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Petrelli, F., Signorelli, D., Ghidini, M., Ghidini, A., Pizzutilo, E. G., Ruggieri, L., Cabiddu, M., Borgonovo, K., Dognini, G., Brighenti, M., et al. (2020) · Cancers · doi:10.3390/cancers12030546 · Cited by 300 · see citing works
The Microbiome–Estrogen Connection and Breast Cancer Risk
Parida, S., & Sharma, D. (2019) · Cells · doi:10.3390/cells8121642 · Cited by 248 · see citing works
Influence of Early Life, Diet, and the Environment on the Microbiome
Dong, T. S., & Gupta, A. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.067 · Cited by 216 · see citing works
Dietary Neurotransmitters: A Narrative Review on Current Knowledge
Briguglio, M., Dell’Osso, B. M., Panzica, G., Malgaroli, A., Banfi, G., Dina, C. Z., Galentino, R., & Porta, M. (2018) · Nutrients · doi:10.3390/nu10050591 · Cited by 213 · see citing works
Self-citationFucà, G., Galli, G., Poggi, M., Lo Russo, G., Proto, C., Imbimbo, M., Ferrara, R., Zilembo, N., Ganzinelli, M., Sica, A., et al. (2019) · ESMO Open · doi:10.1136/esmoopen-2018-000457 · Cited by 209 · see citing works
Song, S., Acharya, K. D., Zhu, J. E., Deveney, C. M., Walther-Antonio, M. R. S., Tetel, M. J., & Chia, N. (2020) · mSphere · doi:10.1128/msphere.00593-20 · Cited by 201 · see citing works
Self-citationLee, H. J., Hong, J. K., Kim, J.-K., Kim, D., Jang, S. W., Han, S.-W., & Yoon, I. (2021) · Nutrients · doi:10.3390/nu13082660 · Cited by 158 · see citing works
Influence of the microbiota-gut-brain axis on behavior and welfare in farm animals: A review
Kraïmi, N., Dawkins, M. S., Gebhardt‐Henrich, S. G., Velge, P., Rychlı́k, I., Volf, J., Créach, P., Smith, A. L., Colles, F. M., & Leterrier, C. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112658 · Cited by 145 · see citing works
Zhang, J., Chen, J., Ding, B., Yongping, L., Liu, K., Wang, L., Le, Y., Liao, Q., Shi, J., Huang, J., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.11.006 · Cited by 132 · see citing works
Cortisol-Related Signatures of Stress in the Fish Microbiome
Webster, T. M. U., Rodríguez‐Barreto, D., Consuegra, S., & de Leániz, C. G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01621 · Cited by 112 · see citing works
Seiler, A., von Känel, R., & Slavich, G. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.565239 · Cited by 110 · see citing works
Luteolin, inflammation and cancer: Special emphasis on gut microbiota
Franza, L., Carusi, V., Nucera, E., & Pandolfi, F. (2021) · BioFactors · doi:10.1002/biof.1710 · Cited by 103 · see citing works
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders
Shahbazi, R., Yasavoli‐Sharahi, H., Alsadi, N., Ismail, N., & Matar, C. (2020) · Molecules · doi:10.3390/molecules25214891 · Cited by 101 · see citing works
Post-finasteride syndrome: An emerging clinical problem
Diviccaro, S., Melcangi, R. C., & Giatti, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100209 · Cited by 98 · see citing works
Self-citationThe role of the gut microbiome in eye diseases
Zysset‐Burri, D. C., Morandi, S. C., Herzog, E. L., Berger, L., & Zinkernagel, M. S. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101117 · Cited by 98 · see citing works
A cross-talk between gut microbiome, salt and hypertension
Naqvi, S., Asar, T. O., Kumar, V., Al-Abbasi, F. A., Alhayyani, S., Kamal, M. A., & Anwar, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111156 · Cited by 95 · see citing works
Svatoň, M., Zemanová, M., Zemanová, P., Kultan, J., Fischer, O., Skřičková, J., Jakubíková, L., Černovská, M., Hrnčiarik, M., JIROUSEK, M., et al. (2020) · Anticancer Research · doi:10.21873/anticanres.14182 · Cited by 90 · see citing works
Photobiomodulation of the microbiome: implications for metabolic and inflammatory diseases
Bicknell, B. T., Liebert, A. D., Johnstone, D. M., & Kiat, H. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2594-6 · Cited by 89 · see citing works
“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?
Liebert, A. D., Bicknell, B. T., Johnstone, D. M., Gordon, L. C., Kiat, H., & Hamblin, M. R. (2019) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2019.4628 · Cited by 87 · see citing works
Gut and vaginal microbiomes on steroids: implications for women’s health
Graham, M. E., Herbert, W. G., Song, S., Raman, H. N., Zhu, J. E., Gonzalez, P. E., Walther-Antonio, M. R. S., & Tetel, M. J. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.04.014 · Cited by 87 · see citing works
Self-citationEstradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice
Acharya, K. D., Gao, X., Bless, E. P., Chen, J., & Tetel, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-56723-1 · Cited by 74 · see citing works
Self-citationAguilera, J., Gálvez-Ontiveros, Y., & Rivas, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.578007 · Cited by 70 · see citing works
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
Ailioaie, L. M., & Litscher, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094942 · Cited by 68 · see citing works
Ma, S., Wang, N., Zhang, P., Wu, W., & Fu, L. (2021) · PeerJ · doi:10.7717/peerj.12293 · Cited by 66 · see citing works
Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep
Thompson, R. S., Vargas, F., Dorrestein, P. C., Chichlowski, M., Berg, B. M., & Fleshner, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60679-y · Cited by 66 · see citing works
Neonatal Stress, Health, and Development in Preterms: A Systematic Review
van Dokkum, N. H., de Kroon, M. L. A., Reijneveld, S. A., & Bos, A. F. (2021) · PEDIATRICS · doi:10.1542/peds.2021-050414 · Cited by 65 · see citing works
Diviccaro, S., Giatti, S., Borgo, F., Barcella, M., Borghi, E., Trejo, J. L., García‐Segura, L. M., & Melcangi, R. C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.021 · Cited by 64 · see citing works
Self-citationCOVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms
Settanni, C. R., Ianiro, G., Ponziani, F. R., Bibbò, S., Segal, J. P., Cammarota, G., & Gasbarrini, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i43.7433 · Cited by 59 · see citing works
Peters, E. M. J., Schedlowski, M., Watzl, C., & Gimsa, U. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100296 · Cited by 61 · see citing works
Marwaha, K., Cain, R., Asmis, K., Czaplinski, K., Holland, N. A., Mayer, D. C. G., & Chacon, J. A. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00652.2024 · Cited by 64 · see citing works
Zeibich, L., Koebele, S. V., Bernaud, V. E., Ilhan, Z., Dirks, B., Northup-Smith, S. N., Neeley, R. E., Maldonado, J., Nirmalkar, K., Files, J. A., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.702628 · Cited by 43 · see citing works
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer
Cianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., Gasbarrini, A., Gambassi, G., & Cammarota, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030501 · Cited by 50 · see citing works
Regulatory effect of gut microbes on blood pressure
Yan, D., Sun, Y. Q., Zhou, X., Si, W., Liu, J., Li, M., & Wu, M. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12233 · Cited by 48 · see citing works
Zhang, Z., Li, N., Chen, R., Lee, T., Gao, Y.-X., Yuan, Z., Nie, Y., & Sun, T. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100333 · Cited by 48 · see citing works
Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions
Ulloa, P. C., Krom, B. P., & van der Veen, M. H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.714229 · Cited by 47 · see citing works
The gut microbiome and antipsychotic treatment response
Seeman, M. V. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112886 · Cited by 45 · see citing works
Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent
Tramullas, M., Collins, J. M., Fitzgerald, P., Dinan, T. G., O’Mahony, S. M., & Cryan, J. F. (2021) · iScience · doi:10.1016/j.isci.2021.102850 · Cited by 44 · see citing works
Self-citationMicrobiome Assisted Tumor Microenvironment: Emerging Target of Breast Cancer
Malla, R. R., Marni, R., Kumari, S., Chakraborty, A., & Pappu, L. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.09.002 · Cited by 44 · see citing works
Host genetics influences the relationship between the gut microbiome and psychiatric disorders
Martins‐Silva, T., Salatino‐Oliveira, A., Genro, J. P., Meyer, F. D. T., Li, Y., Rohde, L. A., Hutz, M. H., & Tovo‐Rodrigues, L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110153 · Cited by 40 · see citing works
Gut dysbiosis and age-related neurological diseases in females
Korf, J. M., Ganesh, B. P., & McCullough, L. D. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105695 · Cited by 41 · see citing works
Dong, T. S., Gee, G. C., Beltrán‐Sánchez, H., Wang, M. D., Osadchiy, V., Kilpatrick, L. A., Chen, Z., Subramanyam, V., Zhang, Y., Guo, Y., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.011 · Cited by 36 · see citing works
Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K., Krone, N. P., Cunliffe, V. T., & van Eeden, F. J. M. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008757 · Cited by 36 · see citing works
Thomas, P., & Pang, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00417 · Cited by 36 · see citing works
Alterations of gut microbiota composition in post-finasteride patients: a pilot study
Borgo, F., Macandog, A. D. G., Diviccaro, S., Falvo, E., Giatti, S., Cavaletti, G., & Melcangi, R. C. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01424-0 · Cited by 36 · see citing works
Self-citationGut bacteria formation and influencing factors
Yang, J., Wu, J., Li, Y., Zhang, Y., Cho, W. C. S., Ju, X., van Schothorst, E. M., & Zheng, Y. (2021) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiab043 · Cited by 35 · see citing works
Paderi, A., Gambale, E., Botteri, C., Giorgione, R., Lavacchi, D., Brugia, M., Mazzoni, F., Giommoni, E., Bormioli, S., Amedei, A., et al. (2021) · Molecules · doi:10.3390/molecules26195789 · Cited by 34 · see citing works
Acharya, K. D., Graham, M., Raman, H., Parakoyi, A. E. R., Corcoran, A., Belete, M., Ramaswamy, B., Koul, S., Sachar, I., Derendorf, K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-31783-6 · Cited by 31 · see citing works
Self-citationThe gut microbiota: emerging biomarkers and potential treatments for infertility-related diseases
Wang, M., Zheng, L., Ma, S., Zhao, D.-H., & Xu, Y. D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1450310 · Cited by 30 · see citing works
Ghrelin as a prominent endocrine factor in stress-induced obesity
van Loenen, M. R., Geenen, B., Arnoldussen, I. A. C., & Kiliaan, A. J. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1863740 · Cited by 30 · see citing works
Effects of Lactobacillus gasseri CP2305 on Mild Menopausal Symptoms in Middle-Aged Women
Sawada, D., Sugawara, T., Hirota, T., & Nakamura, Y. (2022) · Nutrients · doi:10.3390/nu14091695 · Cited by 28 · see citing works
Koh, Y., Lee, P., Kuo, Y., Nagabhushanam, K., Ho, C., & Pan, M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100434 · Cited by 27 · see citing works
Bottaccioli, A., Bologna, M., & Bottaccioli, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073932 · Cited by 23 · see citing works
Hodges, T. E., Eltahir, A. M., Patel, S. D., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104579 · Cited by 26 · see citing works
Antibiotics and steroids, the double enemies of anticancer immunotherapy: a review of the literature
Meriggi, F. A., & Zaniboni, A. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02786-3 · Cited by 25 · see citing works
Xing, S., Jiao, Y., Salehzadeh, M., Soma, K. K., & Huan, T. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04834 · Cited by 25 · see citing works
Aging, testosterone, and neuroplasticity: friend or foe?
Saleki, K., Banazadeh, M., Saghazadeh, A., & Rezaei, N. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0033 · Cited by 25 · see citing works
Li, L., Zou, H.-W., Song, B.-L., Wang, Y., Jiang, Y. H., Li, Z.-L., Niu, Q., & Liu, Y.-J. (2022) · Neuroendocrinology · doi:10.1159/000528876 · Cited by 25 · see citing works
Metagenomic symphony of the intestinal ecosystem: How the composition affects the mind
Malan-Müller, S., Martín-Hernández, D., Caso, J. R., Matthijnssens, J., Rodríguez-Urrutia, A., Lowry, C. A., & Leza, J. C. (2025) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2024.09.033 · Cited by 24 · see citing works
Palego, L., Giannaccini, G., & Betti, L. (2020) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524920999201214231243 · Cited by 25 · see citing works
Acharya, K. D., Noh, H. L., Graham, M. E., Suk, S., Friedline, R. H., Gomez, C. C., Parakoyi, A. E. R., Chen, J., Kim, J. K., & Tetel, M. J. (2021) · Metabolites · doi:10.3390/metabo11080499 · Cited by 24 · see citing works
Self-citationPhysiological mechanisms of unexplained (functional) gastrointestinal disorders
Burns, G. L., Hoedt, E. C., Walker, M. M., Talley, N. J., & Keely, S. (2021) · The Journal of Physiology · doi:10.1113/jp281620 · Cited by 23 · see citing works
Antibiotics, cancer risk and oncologic treatment efficacy: a practical review of the literature
Lopes, M. S. M., Machado, L. M., Silva, P. A. I. A., Uchiyama, A. A. T., Yen, C. T., Ricardo, E. D., Mutão, T. S., Pimento, J. R., Shimba, D. S., Hanriot, R. D. M., et al. (2020) · ecancermedicalscience · doi:10.3332/ecancer.2020.1106 · Cited by 23 · see citing works
The Importance of Gut Microbiota on Choline Metabolism in Neurodegenerative Diseases
Eslami, M., Alibabaei, F., Babaeizad, A., Banihashemian, S. Z., Mazandarani, M., Hoseini, A., Ramezankhah, M., Oksenych, V., & Yousefi, B. (2024) · Biomolecules · doi:10.3390/biom14111345 · Cited by 22 · see citing works
Developmental programming of insulin resistance: are androgens the culprits?
Puttabyatappa, M., Sargis, R. M., & Padmanabhan, V. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0044 · Cited by 22 · see citing works
Bossé, G. D., Cadeddu, R., Floris, G., Farero, R. D., Vigato, E., Lee, S. J., Zhang, T., Gaikwad, N. W., Keefe, K. A., Phillips, P. E. M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143990 · Cited by 22 · see citing works
Farowski, F., Els, G., Tsakmaklis, A., Higgins, P. G., Kahlert, C. R., Stein‐Thoeringer, C. K., Bobardt, J. S., Dettmer‐Wilde, K., Oefner, P. J., Vehreschild, J. J., et al. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1502536 · Cited by 22 · see citing works
Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?
Mengoli, M., Conti, G., Fabbrini, M., Candela, M., Brigidi, P., Turroni, S., & Barone, M. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.24 · Cited by 21 · see citing works
Parment, R., Dubois, M., Desrues, L., Mutel, A., Dembélé, K.-P., Belin, N., Tron, L., Guérin, C., Coëffier, M., Compère, V., et al. (2022) · Cancers · doi:10.3390/cancers14184403 · Cited by 20 · see citing works
Emotional-Single Prolonged Stress: A promising model to illustrate the gut-brain interaction
Marques, L. S., Jung, J. T., Zborowski, V. A., Pinheiro, R. C., Nogueira, C. W., & Zeni, G. R. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114070 · Cited by 19 · see citing works
Correlation between Gut Microbiota and Six Facets of Neuroticism in Korean Adults
Park, E., Yun, K. E., Kim, M.-H., Kim, J., Chang, Y., Ryu, S., Kim, H., Kim, H., & Jung, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121246 · Cited by 19 · see citing works
Sex Differences in Intestinal Microbial Composition and Function of Hainan Special Wild Boar
Wang, X., Zhang, Y., Wen, Q., Wang, Y., Wang, Z., Tan, Z., & Wu, K. (2020) · Animals · doi:10.3390/ani10091553 · Cited by 18 · see citing works
Perfluorobutanesulfonate exposure induces metabolic disturbances in different regions of mouse gut
Chen, L., Zhu, M., Liu, Y., Yang, Z., Li, H., Mu, H., Liu, S., & Wu, B. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.161261 · Cited by 18 · see citing works
mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB)
Abou‐Fadel, J., Jiang, X., Padarti, A., Goswami, D. G., Smith, M., Grajeda, B. I., Bhalli, M., Le, A., Walker, W. E., & Zhang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179684 · Cited by 17 · see citing works
Giatti, S., Diviccaro, S., Cioffi, L., & Melcangi, R. C. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101114 · Cited by 17 · see citing works
Self-citationMind over matter: the microbial mindscapes of psychedelics and the gut-brain axis
Caspani, G., Ruffell, S., Tsang, W., Netzband, N., Rohani-Shukla, C., Swann, J. R., & Jefferies, W. A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107338 · Cited by 18 · see citing works
Abou‐Fadel, J., Jiang, X., Padarti, A., Goswami, D. G., Smith, M., Grajeda, B. I., Walker, W. E., & Zhang, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.10.145003 · Cited by 16 · see citing works
Cusick, J. A., Wellman, C. L., & Demas, G. E. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105146 · Cited by 16 · see citing works
The beneficial roles and mechanisms of estrogens in immune health and infection disease
Chen, L., Xu, T., Lou, J., Zhang, T., Wu, S., Xu, J., & Xu, J. (2024) · Steroids · doi:10.1016/j.steroids.2024.109426 · Cited by 16 · see citing works
Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis
Jain, M., Anand, A., Sharma, N., Shamim, M. A., & Enioutina, E. Y. (2024) · Nutrients · doi:10.3390/nu16203564 · Cited by 17 · see citing works
Hormonal drugs: Influence on growth, biofilm formation, and adherence of selected gut microbiota
Hammouda, Z. K., Wasfi, R., & Abdeltawab, N. F. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1147585 · Cited by 16 · see citing works
Khan, A. G., Kango, N., & Srivastava, R. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10209-9 · Cited by 15 · see citing works
Wilmes, L., Caputi, V., Bastiaanssen, T. F. S., Collins, J. M., Crispie, F., Cotter, P. D., Dinan, T. G., Cryan, J. F., Clarke, G. A., & O’Mahony, S. M. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100686 · Cited by 15 · see citing works
Self-citationAngrish, M. D., Agha, A., & Pezo, R. C. (2021) · Journal of Skin Cancer · doi:10.1155/2021/9120162 · Cited by 15 · see citing works
Primate microbial endocrinology: An uncharted frontier
Benavidez, K. M., Iruri‐Tucker, A. A., Steiniche, T., & Wasserman, M. D. (2019) · American Journal of Primatology · doi:10.1002/ajp.23053 · Cited by 14 · see citing works
Horinouchi, M., & Hayashi, T. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.00143-23 · Cited by 14 · see citing works
Central Serous Chorioretinopathy: Epidemiology, Genetics and Clinical Features
Khan, A. H., & Lotery, A. J. (2024) · Annual Review of Vision Science · doi:10.1146/annurev-vision-102122-102907 · Cited by 14 · see citing works
Jiao, F., Zhou, L., & Wu, Z. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07878-x · Cited by 13 · see citing works
Zheng, W., Su, M., Hong, N., & Ye, P. (2025) · Advances in Ophthalmology Practice and Research · doi:10.1016/j.aopr.2025.01.003 · Cited by 13 · see citing works
Insights into the Human Microbiome and Its Connections with Prostate Cancer
Munteanu, R. A., Feder, R., Onaciu, A., Munteanu, V. C., Iuga, C. A., & Gulei, D. (2023) · Cancers · doi:10.3390/cancers15092539 · Cited by 13 · see citing works
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory
Yang, W., Cui, H., Wang, C., Wang, X., Yan, C., & Cheng, W. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1454780 · Cited by 12 · see citing works
Rajkumar, R. P. (2021) · Life · doi:10.3390/life11090892 · Cited by 13 · see citing works
Guedes, J. D. S., Plá, I., Sahlin, K. B., Monnerat, G., Appelqvist, R., Marko‐Varga, G., Giwercman, A., Domont, G. B., Sánchez, A., Nogueira, F. C. S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-19494-w · Cited by 13 · see citing works
Diviccaro, S., Giatti, S., Cioffi, L., Falvo, E., Herian, M., Caruso, D., & Melcangi, R. C. (2022) · Biomolecules · doi:10.3390/biom12111567 · Cited by 13 · see citing works
Self-citationPhysical Exercise and Mechanism Related to Alzheimer’s Disease: Is Gut–Brain Axis Involved?
Sanchez‐Martinez, J., Solis‐Urra, P., Arancibia, J. E. O., & Plaza‐Díaz, J. (2024) · Brain Sciences · doi:10.3390/brainsci14100974 · Cited by 12 · see citing works
Li, Q., Chen, L., & Wang, R. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1652731 · Cited by 11 · see citing works
Mitchell, L. K., Heussler, H., Burgess, C. J., Rehman, A., Steinert, R. E., & Davies, P. S. W. (2024) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-024-06588-9 · Cited by 11 · see citing works
Gut–Vaginal Microbiome Crosstalk in Ovarian Cancer: Implications for Early Diagnosis
Zhang, H., Lin, H., Zeng, Z., Jia, Y., Zhang, H., Pang, J. M., & Chen, J. J. (2025) · Pathogens · doi:10.3390/pathogens14070635 · Cited by 11 · see citing works
Aswani-Omprakash, T., Balasubramaniam, M., McGarva, J., Pandit, A., Mutlu, E., Hanauer, S. B., & Taft, T. (2023) · Indian Journal of Gastroenterology · doi:10.1007/s12664-023-01424-x · Cited by 11 · see citing works
- Authors
- Tetel, M. J., de Vries, G. J., Melcangi, R. C., Panzica, G., & O'Mahony, S. M.
- Affiliations
- Wellesley College (US)
- Neuroscience Institute Georgia State University Atlanta GA USA
- University of Milan (IT)
- Neuroscience Institute Cavalieri Ottolenghi (IT)
- Department of Anatomy and Neuroscience APC Microbiome Institute University College Cork Cork Ireland
- Corresponding author
- Tetel, M. J.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2018-02
- Volume
- 30
- Issue
- 2
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC6314837
- OpenAlex
- W2762815147
- Cited by
- 187
- References
- 119
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 22 · 2023: 15 · 2022: 28 · 2021: 35 · 2020: 21 · 2019: 14 · 2018: 9
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- National Institute of Mental Health (R21MH108345)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061935)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, gut-brain axis, steroids, stress, corticosteroids, depression, anxiety, stress axis, behavior
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Humans, Gonadal Steroid Hormones, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
