Cited by 13Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Potential Role for Herpesviruses in Alzheimer’s Disease

Duggan, Michael R., Torkzaban, Bahareh, Ahooyi, Taha Mohseni, Khalili, Kamel·2020·Journal of Alzheimer's Disease

Abstract

Across the fields of virology and neuroscience, the role of neurotropic viruses in Alzheimer’s disease (AD) has received renewed enthusiasm, with a particular focus on human herpesviruses (HHVs). Recent genomic analyses of brain tissue collections and investigations of the antimicrobial responses of amyloid-β do not exclude a role of HHVs in contributing to or accelerating AD pathogenesis. Due to continued expansion in our aging cohort and the lack of effective treatments for AD, this composition examines a potential neuroviral theory of AD in light of these recent data. Consideration reveals a possible viral “Hit-and-Run” scenario of AD, as well as neurobiological mechanisms (i.e., neuroinflammation, protein quality control, oxidative stress) that may increase risk for AD following neurotropic infection. Although limitations exist, this theoretical framework reveals several novel therapeutic targets that may prove efficacious in AD.

Integrity signals

Registry

Crossref · 10.3233/jad-200814

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182 of 182 references verified0 citation errors · 0 not checkable

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Authors
Duggan, M. R., Torkzaban, B., Ahooyi, T. M., & Khalili, K.
Affiliations
Temple University (US)
Corresponding author
Khalili, Kamel
Venue
Journal of Alzheimer's Disease
Published
2020-11-24
Volume
78
Issue
3
Pages
855-869
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W3092662199
Cited by
13
References
182
Citations by year
2026: 2 · 2025: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, human herpesviruses
MeSH terms
Host Microbial Interactions, Latent Infection, Alzheimer Disease, Animals, Brain, DNA, Viral, Herpesviridae, Herpesviridae Infections, Humans, Inflammation, Genome, Viral, Oxidative Stress, Viral Tropism, In Vitro Techniques

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