Potential Role for Herpesviruses in Alzheimer’s Disease
Abstract
Across the fields of virology and neuroscience, the role of neurotropic viruses in Alzheimer’s disease (AD) has received renewed enthusiasm, with a particular focus on human herpesviruses (HHVs). Recent genomic analyses of brain tissue collections and investigations of the antimicrobial responses of amyloid-β do not exclude a role of HHVs in contributing to or accelerating AD pathogenesis. Due to continued expansion in our aging cohort and the lack of effective treatments for AD, this composition examines a potential neuroviral theory of AD in light of these recent data. Consideration reveals a possible viral “Hit-and-Run” scenario of AD, as well as neurobiological mechanisms (i.e., neuroinflammation, protein quality control, oxidative stress) that may increase risk for AD following neurotropic infection. Although limitations exist, this theoretical framework reveals several novel therapeutic targets that may prove efficacious in AD.
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Herpesviridae viruses can be implicated in late-onset Alzheimer's disease pathogenesis.
“Herpesviridae viruses can be implicated in late-onset Alzheimer’s disease pathogenesis [35, 36]”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [36]
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Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Duggan, M. R., Peng, Z., An, Y., Kitner Triolo, M. H., Shafer, A. T., Davatzikos, C., Erus, G., Karikkineth, A., Lewis, A., Moghekar, A., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000201036 · Cited by 24 · see citing works
Self-citation
- Authors
- Duggan, M. R., Torkzaban, B., Ahooyi, T. M., & Khalili, K.
- Affiliations
- Temple University (US)
- Corresponding author
- Khalili, Kamel
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2020-11-24
- Volume
- 78
- Issue
- 3
- Pages
- 855-869
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W3092662199
- Cited by
- 13
- References
- 182
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, human herpesviruses
- MeSH terms
- Host Microbial Interactions, Latent Infection, Alzheimer Disease, Animals, Brain, DNA, Viral, Herpesviridae, Herpesviridae Infections, Humans, Inflammation, Genome, Viral, Oxidative Stress, Viral Tropism, In Vitro Techniques
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