The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
The Role of Estrogen in Brain and Cognitive Aging
Open accessAbstract
There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline rapidly over the menopausal transition. This decline in E2 has been associated with a number of changes in the brain, including cognitive changes, effects on sleep, and effects on mood. These effects have been demonstrated in both rodent and non-human preclinical models. Furthermore, E2 interactions have been indicated in a number of neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. In normal brain aging, there are a number of systems that undergo changes and a number of these show interactions with E2, particularly the cholinergic system, the dopaminergic system, and mitochondrial function. E2 treatment has been shown to ameliorate some of the behavioral and morphological changes seen in preclinical models of menopause; however, in clinical populations, the effects of E2 treatment on cognitive changes after menopause are mixed. The future use of sex hormone treatment will likely focus on personalized or precision medicine for the prevention or treatment of cognitive disturbances during aging, with a better understanding of who may benefit from such treatment.
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“its level quickly decreases throughout menopause. 118”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [118]
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“among these estrogens, E2 is the most active”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [118]
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Cited by
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Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“118 E2 has been demonstrated in numerous studies to alter systems involved in the pathophysiology of depression, including the serotonin and norepinephrine systems, and to considerably alleviate depressive symptoms in animal models.”
BackgroundRole of estrogen receptors in health and disease
Chen, P., Li, B., & Ou-Yang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839005 · Cited by 339
Unraveling female reproductive senescence to enhance healthy longevity
Dong, L., Teh, D. B. L., Kennedy, B. K., & Huang, Z. (2023) · Cell Research · doi:10.1038/s41422-022-00718-7 · Cited by 101
Aging conundrum: A perspective for ovarian aging
Wu, J., Liu, Y., Song, Y., Wang, L., Ai, J., & Li, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.952471 · Cited by 73
Schwarz, K. G., Vicencio, S. C., Inestrosa, N. C., Villaseca, P., & Del Rio, R. (2024) · The Journal of Physiology · doi:10.1113/jp285126 · Cited by 40
Metadata
- Authors
- Russell, J. K., Jones, C. K., & Newhouse, P. A.
- Affiliations
- Vanderbilt University (US)
- VA Tennessee Valley Healthcare System (US)
- Corresponding author
- Newhouse, Paul A.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 16
- Issue
- 3
- Pages
- 649-665
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC6694379
- OpenAlex
- W2964886730
- Cited by
- 257
- References
- 226
- Citations by year
- 2026: 50 · 2025: 56 · 2024: 56 · 2023: 37 · 2022: 32 · 2021: 16 · 2020: 8 · 2019: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG047992, 1R01AG054622)
- Alzheimer’s Association (PCTR-16-383171)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Keywords
- estrogen, estradiol, menopause, cognitive aging, brain aging, sex hormones, Alzheimer's disease, schizophrenia, depression, cholinergic system, dopaminergic system, mitochondrial function, sleep, mood, hormone replacement therapy, precision medicine
- MeSH terms
- Cognitive Aging, Animals, Brain, Estrogens, Humans
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