Cited by 257Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsPhytoestrogen effects and research

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The Role of Estrogen in Brain and Cognitive Aging

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Russell, Jason K., Jones, Carrie K., Newhouse, Paul A.·2019·Neurotherapeutics

DOI 10.1007/s13311-019-00766-9PMC PMC6694379

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Abstract

There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline rapidly over the menopausal transition. This decline in E2 has been associated with a number of changes in the brain, including cognitive changes, effects on sleep, and effects on mood. These effects have been demonstrated in both rodent and non-human preclinical models. Furthermore, E2 interactions have been indicated in a number of neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. In normal brain aging, there are a number of systems that undergo changes and a number of these show interactions with E2, particularly the cholinergic system, the dopaminergic system, and mitochondrial function. E2 treatment has been shown to ameliorate some of the behavioral and morphological changes seen in preclinical models of menopause; however, in clinical populations, the effects of E2 treatment on cognitive changes after menopause are mixed. The future use of sex hormone treatment will likely focus on personalized or precision medicine for the prevention or treatment of cognitive disturbances during aging, with a better understanding of who may benefit from such treatment.

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Authors: Russell, J. K., Jones, C. K., & Newhouse, P. A.
Affiliations: Vanderbilt University (US)
VA Tennessee Valley Healthcare System (US)
Corresponding author: Newhouse, Paul A.
ORCID: Russell, Jason K.
Jones, Carrie K.
Newhouse, Paul A.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2019-07
Volume: 16
Issue: 3
Pages: 649-665
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1007/s13311-019-00766-9
PMC: PMC6694379
OpenAlex: W2964886730
Cited by: 257
References: 226
Citations by year: 2026: 50 · 2025: 56 · 2024: 56 · 2023: 37 · 2022: 32 · 2021: 16 · 2020: 8 · 2019: 2
FWCI: 2.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1514 d)
Locations: Neurotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG047992, 1R01AG054622)
Alzheimer’s Association (PCTR-16-383171)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Keywords: estrogen, estradiol, menopause, cognitive aging, brain aging, sex hormones, Alzheimer's disease, schizophrenia, depression, cholinergic system, dopaminergic system, mitochondrial function, sleep, mood, hormone replacement therapy, precision medicine
MeSH terms: Cognitive Aging, Animals, Brain, Estrogens, Humans

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The Role of Estrogen in Brain and Cognitive Aging

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