The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Nutrients, Clock Genes, and Chrononutrition
Open accessAbstract
Circadian clocks that comprise clock genes exist throughout the body and control daily physiological events. The central clock that dominates activity rhythms is entrained by light/dark cycles, whereas peripheral clocks regulating local metabolic rhythms are determined by feeding/fasting cycles. Nutrients reset peripheral circadian clocks and the local clock genes control downstream metabolic processes. Metabolic states also affect the clockworks in feedback manners. Because the circadian system organizes whole energy homeostasis, including food intake, fat accumulation, and caloric expenditure, the disruption of circadian clocks leads to metabolic disorders. Recent findings show that time-restricted feeding during the active phase amplifies circadian clocks and improves metabolic disorders induced by a high-fat diet without caloric reduction, whereas unusual/irregular food intake induces various metabolic dysfunctions. Such evidence from nutrition studies that consider circadian system (chrononutrition) has rapidly accumulated. We review molecular relationships between circadian clocks and nutrition as well as recent chrononutrition findings.
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“These include poor-quality diet [232], improper meal timing and altered feeding-fasting behavior [233,234], sub-optimal exercise timing [235], disrupted sleep-wake cycles [236], shift work [237], EDC [238], and stress [239,240].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [234]
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“In this context, because breakfast is consumed after the longest fasting period of the day, it is usually the most important meal to modulate the phase of the liver clock [270].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [270]
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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
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High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
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Cited by
Sorted by citations
de Toro‐Martín, J., Arsenault, B. J., Després, J., & Vohl, M. (2017) · Nutrients · doi:10.3390/nu9080913 · Cited by 534
The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
Paoli, A., Tinsley, G. M., Bianco, A., & Moro, T. (2019) · Nutrients · doi:10.3390/nu11040719 · Cited by 415
Atger, F., Gobet, C., Marquis, J., Martín, E., Wang, J., Weger, B. D., Lefebvre, G. C., Descombes, P., Naef, F., & Gachon, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515308112 · Cited by 254
New Insights Into the Circadian Rhythm and Its Related Diseases
Xie, Y., Tang, Q., Chen, G., Xie, M., Yu, S., Zhao, J., & Chen, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00682 · Cited by 250
Qasim, A., Turcotte, M., de Souza, R. J., Samaan, M. C., Champredon, D., Dushoff, J., Speakman, J. R., & Meyre, D. (2018) · Obesity Reviews · doi:10.1111/obr.12625 · Cited by 241
Metadata
- Authors
- Oike, H., Oishi, K., & Kobori, M.
- Affiliations
- National Agriculture and Food Research Organization (JP)
- Tokyo University of Science (JP)
- Corresponding author
- Oike, Hideaki
- Venue
- Current Nutrition Reports
- Published
- 2014-04-27
- Volume
- 3
- Issue
- 3
- Pages
- 204-212
- ISSN
- 2161-3311 (ISSN-L)
- PMC
- PMC4118017
- OpenAlex
- W2072829785
- Cited by
- 198
- References
- 101
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 17 · 2023: 20 · 2022: 20 · 2021: 19 · 2020: 21 · 2019: 18 · 2018: 7 · 2017: 18 · 2016: 9 · 2015: 12 · 2014: 2
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Nutrition Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25560066, 25702005, 25350179)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- circadian clock, clock genes, chrononutrition, time-restricted feeding, metabolic disorders, high-fat diet, energy homeostasis, dietary intake, fat deposition, energy expenditure, circadian rhythm disruption
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