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Cited by 250Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

New Insights Into the Circadian Rhythm and Its Related Diseases

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Xie, Yanling, Tang, Qingming, Chen, Guangjin, Xie, Mengru, Yu, Shaoling, Zhao, Jiajia, Chen, Lili·2019·Frontiers in Physiology
DOI 10.3389/fphys.2019.00682PMC PMC6603140
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Abstract

Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by the molecular circadian clock which acting on coordinating internal time with the external environment in a 24-h daily cycle. The circadian clock system is a major regulatory factor for nearly all physiological activities and its disorder has severe consequences on human health. CR disruption is a common issue in modern society, and researches about people with jet lag or shift works have revealed that CR disruption can cause cognitive impairment, psychiatric illness, metabolic syndrome, dysplasia, and cancer. In this review, we summarized the synchronizers and the synchronization methods used in experimental research, and introduced CR monitoring and detection methods. Moreover, we evaluated conventional CR databases, and analyzed experiments that characterized the underlying causes of CR disorder. Finally, we further discussed the latest developments in understanding of CR disruption, and how it may be relevant to health and disease. Briefly, this review aimed to synthesize previous studies to aid in future studies of CR and CR-related diseases.

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  • Circadian rhythm regulates some biological activities such as sleep and mood through various mechanisms such as the TTFL, which includes two transcription activators: CLOCK and BMAL1. Both activators create a heterodimer, which inhibits the transcription of repressor proteins PER2 and CRY that regulates the daily rhythms of locomotor activity, metabolism and behaviour.

    “Circadian rhythm regulates some biological activities such as sleep and mood [113] through various mechanisms such as the transcription-translation feedback loop (TTFL), which includes two transcription activators: circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1). Both activators create a heterodimer, which inhibits the transcription of repressor pro”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [114]

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Authors
Xie, Y., Tang, Q., Chen, G., Xie, M., Yu, S., Zhao, J., & Chen, L.
Affiliations
Wuhan Union Hospital (CN)
Corresponding author
  • Zhao, Jiajia
  • Chen, Lili
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2019-06-25
Volume
10
Pages
682-682
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2019.00682
PMC
PMC6603140
OpenAlex
W2955399147
Cited by
250
References
249
Citations by year
2026: 18 · 2025: 15 · 2024: 39 · 2023: 31 · 2022: 61 · 2021: 38 · 2020: 45 · 2019: 2 · 2018: 1
FWCI
20.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Natural Science Foundation of China (31725011)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm, circadian clock, circadian rhythm disruption, jet lag, shift work, circadian synchronization, cognitive impairment, mental illness, metabolic syndrome, cancer, dysplasia

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