Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
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Transcription Around the Clock: The biological clock that controls daily rhythms in mammalian physiology and behavior is thought to be regulated in large part by transcriptional events (see the Perspective by Doherty and Kay ). Koike et al. (p. 349 ; published online 30 August) produced a comprehensive analysis of these transcriptional events across the entire mouse liver genome over a 24-hour period. Only ∼22% of cycling messenger RNA transcripts were driven by de novo transcription, suggesting that posttranscriptional events also play an important regulatory role in the mammalian clock. Biological timing in organisms can also respond to rhythmic cues from the environment. Morf et al. (p. 379 , published online 23 August) explored how one such cue, cycles in ambient temperature, influence circadian timing in mammalian cells. Cold-inducible RNA–binding protein (CIRP) accumulates when body temperature is low. A systematic search for binding partners of CIRP identified RNA encoding core components of the circadian clock. Loss of CIRP decreased the amplitude of circadian gene expression and cells lacking CIRP adapted more quickly to temperature cycles.
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In wild-type mouse livers, BMAL1/CLOCK transcriptional activity is low at ZT2 and ZT18 but peaks at ZT6.
“In the livers of WT mice, BMAL1/CLOCK transcriptional activity is low at ZT2 and 18 but peaks at ZT6 (Koike et al., 2012)”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Koike et al., 2012
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The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · see citing works
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450 · see citing works
Self-citationYoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works
Self-citationCoordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233 · see citing works
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 1,997 · see citing works
Self-citationNascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
Core, L. J., Waterfall, J. J., & Lis, J. T. (2008) · Science · doi:10.1126/science.1162228 · Cited by 1,986 · see citing works
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 1,946 · see citing works
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works
Self-citationWebGestalt: an integrated system for exploring gene sets in various biological contexts
Zhang, B., Kirov, S. A., & Snoddy, J. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki475 · Cited by 1,801 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
Self-citationmCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works
Self-citationc-Myc Regulates Transcriptional Pause Release
Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,158 · see citing works
Self-citationHughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087 · see citing works
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works
A high-resolution map of active promoters in the human genome
Kim, T. H., Barrera, L., Zheng, M., Qu, C.-X., Singer, M. A., Richmond, T., Wu, Y. N., Green, R. D., & Ren, B. (2005) · Nature · doi:10.1038/nature03877 · Cited by 1,019 · see citing works
Self-citationEnhancer function: new insights into the regulation of tissue-specific gene expression
Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works
Elongation by RNA polymerase II: the short and long of itPreprint
Sims, R. J., Belotserkovskaya, R., & Reinberg, D. (2004) · Genes & Development · doi:10.1101/gad.1235904 · Cited by 709 · see citing works
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
Etchegaray, J.-P., Lee, C., Wade, P. A., & Reppert, S. M. (2003) · Nature · doi:10.1038/nature01314 · Cited by 679 · see citing works
Self-citationHarmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 674 · see citing works
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646 · see citing works
Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 593 · see citing works
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works
Genetics of Circadian Rhythms in Mammalian Model Organisms
Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 578 · see citing works
Self-citationDefining mechanisms that regulate RNA polymerase II transcription in vivo
Fuda, N. J., Ardehali, M. B., & Lis, J. T. (2009) · Nature · doi:10.1038/nature08449 · Cited by 576 · see citing works
NPAS2: an analog of clock operative in the mammalian forebrain
Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572 · see citing works
Siepka, S. M., Yoo, S. H., Park, J., Song, W., Kumar, V., Hu, Y., Lee, C., & Takahashi, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.04.030 · Cited by 536 · see citing works
Self-citationDeconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532 · see citing works
Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 511 · see citing works
Busino, L., Bassermann, F. C., Maiolica, A., Lee, C., Nolan, P. M., Godinho, S. I. H., Draetta, G. F., & Pagano, M. (2007) · Science · doi:10.1126/science.1141194 · Cited by 509 · see citing works
Self-citationRev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint
Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works
Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., & Naef, F. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000595 · Cited by 473 · see citing works
A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Zhang, E. E., Liu, A. C., Hirota, T., Miraglia, L. J., Welch, G. L., Pongsawakul, P. Y., Liu, X., Atwood, A., Huss, J. W., Janes, J. O., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.031 · Cited by 432 · see citing works
A Molecular Mechanism for Circadian Clock Negative Feedback
Duong, H. A., Robles, M. S., Knutti, D., & Weitz, C. J. (2011) · Science · doi:10.1126/science.1196766 · Cited by 362 · see citing works
Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes & Development · doi:10.1101/gad.564110 · Cited by 361 · see citing works
Ameur, A., Zaghlool, A., Halvardson, J., Wetterbom, A., Gyllensten, U., Cavelier, L., & Feuk, L. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2143 · Cited by 323 · see citing works
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
Chapman, R. D., Heidemann, M., Albert, T., Mailhammer, R., Flatley, A., Meisterernst, M., Kremmer, E., & Eick, D. (2007) · Science · doi:10.1126/science.1145977 · Cited by 323 · see citing works
Shirogane, T., Jin, J., Cambronne, X. A., & Harper, J. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502862200 · Cited by 293 · see citing works
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Katada, S., & Sassone‐Corsi, P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1961 · Cited by 291 · see citing works
Clocks, metabolism, and the epigenome
Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · see citing works
Nowak, D. E., Tian, B., & Brasier, A. R. (2005) · BioTechniques · doi:10.2144/000112014 · Cited by 253 · see citing works
Post-transcriptional control of circadian rhythms
Kojima, S., Shingle, D. L., & Green, C. B. (2011) · Journal of Cell Science · doi:10.1242/jcs.065771 · Cited by 247 · see citing works
Association of p300 and CBP with Simian Virus 40 Large T Antigen
Eckner, R., Ludlow, J. W., Lill, N. L., Oldread, E., Arany, Z. P., Modjtahedi, N., DeCaprio, J. A., Livingston, D. M., & Morgan, J. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3454 · Cited by 243 · see citing works
PeakAnalyzer: Genome-wide annotation of chromatin binding and modification loci
Salmon‐Divon, M., Dvinge, H., Koort, K., & Bertone, P. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-415 · Cited by 238 · see citing works
Chen, R., Schirmer, A. E., Lee, Y., Lee, H.-M., Kumar, V., Yoo, S. H., Takahashi, J. S., & Lee, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.012 · Cited by 225 · see citing works
Self-citationYang, R., & Su, Z. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq189 · Cited by 211 · see citing works
Zeng, P.-Y., Vakoc, C. R., Chen, Z., Blobel, G. A., & Berger, S. L. (2006) · BioTechniques · doi:10.2144/000112297 · Cited by 190 · see citing works
β-TrCP1-Mediated Degradation of PERIOD2 Is Essential for Circadian Dynamics
Reischl, S., Vanselow, K., Westermark, P. O., Thierfelder, N., Maier, B., Herzel, H., & Kramer, A. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407303926 · Cited by 176 · see citing works
Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex
Padmanabhan, K., Robles, M. S., Westerling, T., & Weitz, C. J. (2012) · Science · doi:10.1126/science.1221592 · Cited by 173 · see citing works
Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock
Lee, C., Weaver, D. R., & Reppert, S. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.584-594.2004 · Cited by 159 · see citing works
Self-citationRole for antisense RNA in regulating circadian clock function in Neurospora crassa
Kramer, C., Loros, J., Dunlap, J., & Crosthwaite, S. K. (2003) · Nature · doi:10.1038/nature01427 · Cited by 159 · see citing works
WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit
Duncan, D. T., Prodduturi, N., & Zhang, B. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-s4-p10 · Cited by 147 · see citing works
Hatanaka, F., Matsubara, C., Myung, J., Yoritaka, T., Kamimura, N., Tsutsumi, S., Kanai, A., Suzuki, Y., Sassone‐Corsi, P., Aburatani, H., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00781-10 · Cited by 142 · see citing works
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNAPreprint
Menet, J. S., Abruzzi, K. C., Desrochers, J., Rodriguez, J., & Rosbash, M. (2010) · Genes & Development · doi:10.1101/gad.1883910 · Cited by 136 · see citing works
Understanding systems-level properties: timely stories from the study of clocks
Hogenesch, J. B., & Ueda, H. R. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2972 · Cited by 136 · see citing works
Plasticity and specificity of the circadian epigenome
Masri, S., & Sassone‐Corsi, P. (2010) · Nature Neuroscience · doi:10.1038/nn.2668 · Cited by 132 · see citing works
Jones, J. C., Phatnani, H. P., Haystead, T., MacDonald, J. A., Alam, S. M., & Greenleaf, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402218200 · Cited by 130 · see citing works
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
Ye, R., Selby, C. P., Öztürk, N., Annayev, Y., & Sancar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254680 · Cited by 129 · see citing works
Coactivation of the CLOCK–BMAL1 complex by CBP mediates resetting of the circadian clock
Lee, Y., Lee, J., Kwon, I., Nakajima, Y., Ohmiya, Y., Son, G. H., Lee, K. H., & Kim, K. (2010) · Journal of Cell Science · doi:10.1242/jcs.070300 · Cited by 118 · see citing works
MSOAR 2.0: Incorporating tandem duplications into ortholog assignment based on genome rearrangement
Shi, G., Zhang, L., & Jiang, T. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-10 · Cited by 109 · see citing works
The role of the transcriptional activator protein DBP in circadian liver gene expression
Wuarin, J., Falvey, E., Lavery, D. J., Talbot, D., Schmidt, E., Ossipow, V., Fonjallaz, P., & Schibler, U. (1992) · Journal of Cell Science · doi:10.1242/jcs.1992.supplement_16.15 · Cited by 96 · see citing works
Stratmann, M., Stadler, F., Tamanini, F., van der Horst, G. T. J., & Ripperger, J. A. (2010) · Genes & Development · doi:10.1101/gad.578810 · Cited by 70 · see citing works
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription
Hosoda, H., Kato, K., Asano, H., Ito, M., Kato, H., Iwamoto, T., Suzuki, A. Z., Masushige, S., & Kida, S. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-34 · Cited by 66 · see citing works
Spotlight on post-transcriptional control in the circadian system
Staiger, D., & Köster, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0513-5 · Cited by 50 · see citing works
Towards a General Solution to Drawing Area-Proportional Euler Diagrams
Chow, S., & Ruskey, F. (2005) · Electronic Notes in Theoretical Computer Science · doi:10.1016/j.entcs.2005.02.017 · Cited by 32 · see citing works
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Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works
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Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works
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Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,190 · see citing works
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Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works
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Fustin, J., Doi, M., Yamaguchi, Y., Hayashi, H., Nishimura, S., Yoshida, M., Isagawa, T., Morioka, M. S., Kakeya, H., Manabe, I., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.026 · Cited by 980 · see citing works
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
Thaiss, C. A., Levy, M., Korem, T., Dohnalová, L., Shapiro, H., Jaitin, D. A., David, E., Winter, D. R., Gury-BenAri, M., Tatirovsky, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.003 · Cited by 870 · see citing works
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.036 · Cited by 744 · see citing works
Self-citationMolecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works
Self-citationReprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 711 · see citing works
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock
Chaix, A., Lin, T. C., Le, H. D., Chang, M. W., & Panda, S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.004 · Cited by 678 · see citing works
Circadian Clock Proteins and Immunity
Curtis, A. M., Bellet, M. M., Sassone‐Corsi, P., & O'Neill, L. A. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.002 · Cited by 644 · see citing works
Circadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 616 · see citing works
Crosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
Genomics of circadian rhythms in health and disease
Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 537 · see citing works
Self-citationInterplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Etchegaray, J., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 521 · see citing works
Circadian Mechanisms in Medicine
Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519 · see citing works
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.007 · Cited by 508 · see citing works
“Previous studies have suggested that BMAL1/CLOCK and the PAR-domain basic leucine zipper transcription factor DBP may co-activate Car over a 24 hr period in the liver (Gachon et al., 2006; Koike et al., 2012; Ripperger and Schibler, 2006).”
BackgroundInfluentialSelf-citationHe, B., Nohara, K., Park, N., Park, Y.-S., Guillory, B., Zhao, Z., Garcia, J. M., Koike, N., Lee, C. C., Takahashi, J. S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.007 · Cited by 505 · see citing works
Self-citationCircadian clock genes and the transcriptional architecture of the clock mechanism
Cox, K. H., & Takahashi, J. S. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0153 · Cited by 481 · see citing works
Self-citationT H 17 Cell Differentiation Is Regulated by the Circadian Clock
Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V. (2013) · Science · doi:10.1126/science.1243884 · Cited by 445 · see citing works
Self-citationPeek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M., Ramsey, K. M., & Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.010 · Cited by 415 · see citing works
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410 · see citing works
Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness
Jacobi, D., Liu, S., Burkewitz, K., Kory, N., Knudsen, N. H., Alexander, R., Ünlütürk, U., Li, X., Kong, X., Hyde, A. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.006 · Cited by 411 · see citing works
Self-citationThe emerging link between cancer, metabolism, and circadian rhythms
Masri, S., & Sassone‐Corsi, P. (2018) · Nature Medicine · doi:10.1038/s41591-018-0271-8 · Cited by 406 · see citing works
Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases
Chaix, A., Manoogian, E. N. C., Melkani, G. C., & Panda, S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124320 · Cited by 402 · see citing works
Mistimed sleep disrupts circadian regulation of the human transcriptome
Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316335111 · Cited by 386 · see citing works
Robles, M. S., Cox, J., & Mann, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004047 · Cited by 383 · see citing works
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Izumo, M., Xu, P., Wight‐Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 361 · see citing works
Self-citationCircadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370 · see citing works
Medicine in the Fourth Dimension
Cederroth, C. R., Albrecht, U., Bass, J. T., Brown, S. A., Dyhrfjeld‐Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich‐Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 363 · see citing works
Self-citationEsnault, C., Stewart, A., Gualdrini, F., East, P., Horswell, S. D., Matthews, N., & Treisman, R. (2014) · Genes & Development · doi:10.1101/gad.239327.114 · Cited by 355 · see citing works
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology
Robles, M. S., Humphrey, S. J., & Mann, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.004 · Cited by 355 · see citing works
Time-restricted eating for the prevention and management of metabolic diseases
Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344 · see citing works
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation
Lipton, J. O., Yuan, E. D., Boyle, L. M., Ebrahimi‐Fakhari, D., Kwiatkowski, E. R., Nathan, A., Guettler, T., Davis, F. C., Asara, J. M., & Şahin, M. (2015) · Cell · doi:10.1016/j.cell.2015.04.002 · Cited by 342 · see citing works
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks
Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 335 · see citing works
Ballesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 342 · see citing works
MYC and metabolism on the path to cancer
Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.003 · Cited by 337 · see citing works
Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329 · see citing works
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation
Menet, J. S., Rodriguez, J., Abruzzi, K. C., & Rosbash, M. (2012) · eLife · doi:10.7554/elife.00011 · Cited by 321 · see citing works
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Yang, G., Chen, L., Grant, G. R., Paschos, G. K., Song, W., Musiek, E. S., Lee, V., McLoughlin, S. C., Großer, T., Cotsarelis, G., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3305 · Cited by 317 · see citing works
Defining the Independence of the Liver Circadian Clock
Koronowski, K. B., Kinouchi, K., Welz, P.-S., Smith, J. G., Zinna, V. M., Shi, J., Samad, M., Chen, S., Magnan, C. N., Kinchen, J. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.025 · Cited by 308 · see citing works
Gaidatzis, D., Burger, L., Florescu, M., & Stadler, M. B. (2015) · Nature Biotechnology · doi:10.1038/nbt.3269 · Cited by 313 · see citing works
Lane, J. M., Vlasac, I., Anderson, S. G., Kyle, S. D., Dixon, W. G., Bechtold, D. A., Gill, S., Little, M. A., Luik, A., Loudon, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10889 · Cited by 312 · see citing works
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y.-J., Liu, C., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.01.013 · Cited by 307 · see citing works
Self-citationCommunicating clocks shape circadian homeostasis
Koronowski, K. B., & Sassone‐Corsi, P. (2021) · Science · doi:10.1126/science.abd0951 · Cited by 299 · see citing works
Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.050 · Cited by 292 · see citing works
Core circadian clock genes regulate leukemia stem cells in AML
Puram, R. V., Kowalczyk, M. S., de Boer, C. G., Schneider, R. K., Miller, P. G., McConkey, M., Tothova, Z., Tejero, H., Heckl, D., Järås, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.015 · Cited by 274 · see citing works
Wu, Y., Tang, D., Liu, N., Xiong, W., Huang, H., Li, Y., Ma, Z., Zhao, H., Chen, P., Qi, X., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.009 · Cited by 285 · see citing works
Self-citationTargeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
Dong, Z., Zhang, G., Qu, M., Gimple, R. C., Wu, Q., Qiu, Z., Prager, B. C., Wang, X., Kim, L. J. Y., Morton, A. R., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0215 · Cited by 284 · see citing works
Self-citationRhythmic Oxygen Levels Reset Circadian Clocks through HIF1α
Adamovich, Y., Ladeuix, B., Golik, M., Koeners, M. P., & Asher, G. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.014 · Cited by 283 · see citing works
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation
Zhong, X., Yu, J., Frazier, K., Weng, X., Li, Y., Cham, C. M., Dolan, K. T., Zhu, X., Hubert, N., Tao, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.068 · Cited by 281 · see citing works
Guidelines for Genome-Scale Analysis of Biological Rhythms
Hughes, M. E., Abruzzi, K. C., Allada, R., Anafi, R. C., Arpat, A. B., Asher, G., Baldi, P., de Bekker, C., Bell‐Pedersen, D., Blau, J., et al. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417728663 · Cited by 280 · see citing works
Self-citationClocks, cancer, and chronochemotherapy
Sancar, A., & Gelder, R. N. V. (2020) · Science · doi:10.1126/science.abb0738 · Cited by 276 · see citing works
Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock
Kamioka, M., Takao, S., Suzuki, T., Taki, K., Higashiyama, T., Kinoshita, T., & Nakamichi, N. (2016) · The Plant Cell · doi:10.1105/tpc.15.00737 · Cited by 276 · see citing works
Herzog, E. D., Hermanstyne, T. O., Smyllie, N. J., & Hastings, M. H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027706 · Cited by 268 · see citing works
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260 · see citing works
Self-citationMelatonin feedback on clock genes: a theory involving the proteasome
Vriend, J. P., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12189 · Cited by 268 · see citing works
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 262 · see citing works
Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis
Nagel, D. H., Doherty, C. J., Pruneda-Paz, J. L., Schmitz, R. J., Ecker, J. R., & Kay, S. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513609112 · Cited by 259 · see citing works
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251 · see citing works
Vollmers, C., Schmitz, R. J., Nathanson, J. L., Yeo, G. W.-M., Ecker, J. R., & Panda, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.004 · Cited by 253 · see citing works
Genetic basis of chronotype in humans: insights from three landmark GWAS
Kalmbach, D. A., Schneider, L. D., Cheung, J., Bertrand, S. J., Kariharan, T., Pack, A. I., & Gehrman, P. R. (2017) · Sleep · doi:10.1093/sleep/zsw048 · Cited by 243 · see citing works
Atger, F., Gobet, C., Marquis, J., Martín, E., Wang, J., Weger, B. D., Lefebvre, G. C., Descombes, P., Naef, F., & Gachon, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515308112 · Cited by 252 · see citing works
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019) · Science · doi:10.1126/science.aav2642 · Cited by 248 · see citing works
CLOCK:BMAL1 is a pioneer-like transcription factorPreprint
Menet, J. S., Pescatore, S., & Rosbash, M. (2014) · Genes & Development · doi:10.1101/gad.228536.113 · Cited by 252 · see citing works
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works
Self-citationMacromolecular Assemblies of the Mammalian Circadian Clock
Aryal, R. P., Kwak, P. B., Tamayo, A. G., Gebert, M., Chiu, P., Walz, T., & Weitz, C. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.017 · Cited by 246 · see citing works
The circadian clock and liver function in health and disease
Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246 · see citing works
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Alam, H., Tang, M., Maitituoheti, M., Dhar, S. S., Kumar, M., Han, C. Y., Ambati, C. R., Amin, S. B., Gu, B., Chen, T.-Y., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.005 · Cited by 243 · see citing works
Ye, R., Selby, C. P., Chiou, Y., Ozkan‐Dagliyan, I., Gaddameedhi, S., & Sancar, A. (2014) · Genes & Development · doi:10.1101/gad.249417.114 · Cited by 247 · see citing works
Circadian timing of metabolism in animal models and humans
Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works
Chronopharmacology: New Insights and Therapeutic Implications
Dallmann, R., Brown, S. A., & Gachon, F. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135923 · Cited by 244 · see citing works
Circadian rhythms in the absence of the clock gene Bmal1
Ray, S., Valekunja, U. K., Stangherlin, A., Howell, S. A., Snijders, A. P., Damodaran, G., & Reddy, A. B. (2020) · Science · doi:10.1126/science.aaw7365 · Cited by 236 · see citing works
Watanabe, K., Jansen, P. R., Savage, J. E., Nandakumar, P., Wang, X., Agee, M., Aslibekyan, S. W., Auton, A., Bell, R. K., Bryc, K., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01124-w · Cited by 234 · see citing works
Honma, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0597-5 · Cited by 233 · see citing works
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas, G., Peixoto, F. O., Perdiguero, E., Jardı́, M., Ruiz‐Bonilla, V., Datta, D., Symeonidi, A., Castellanos‐Martín, A., Welz, P.-S., Caballero, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.035 · Cited by 229 · see citing works
Circadian rhythms of liver physiology and disease: experimental and clinical evidence
Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 231 · see citing works
Molecular components of the circadian clock in mammals
Takahashi, J. S. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12514 · Cited by 230 · see citing works
Self-citationCell autonomous regulation of herpes and influenza virus infection by the circadian clock
Edgar, R. S., Stangherlin, A., Nagy, A. D., Nicoll, M. P., Efstathiou, S., O'Neill, J. S., & Reddy, A. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601895113 · Cited by 227 · see citing works
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.031 · Cited by 219 · see citing works
Barca‐Mayo, O., Pons‐Espinal, M., Follert, P., Armirotti, A., Berdondini, L., & Tonelli, D. D. P. (2017) · Nature Communications · doi:10.1038/ncomms14336 · Cited by 222 · see citing works
Circadian rhythms in mitochondrial respiration
de Goede, P., Wefers, J., Brombacher, E. C., Schrauwen, P., & Kalsbeek, A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0196 · Cited by 211 · see citing works
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211 · see citing works
Circadian Oscillators: Around the Transcription–Translation Feedback Loop and on to Output
Hurley, J., Loros, J., & Dunlap, J. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.009 · Cited by 206 · see citing works
Histone propionylation is a mark of active chromatin
Kebede, A. F., Nieborak, A., Shahidian, L. Z., Gras, S. L., Richter, F. M., Aguilar‐Gómez, D., Baltissen, M. P. A., Mészáros, G., Magliarelli, H. D. F., Taudt, A., et al. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3490 · Cited by 203 · see citing works
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing
Hoyle, N. P., Seinkmane, E., Putker, M., Feeney, K. A., Krogager, T. P., Chesham, J. E., Bray, L. K., Thomas, J. M., Dunn, K., Blaikley, J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2774 · Cited by 205 · see citing works
mTOR signaling regulates central and peripheral circadian clock function
Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 206 · see citing works
Self-citationMartelot, G. L., Canella, D., Symul, L., Migliavacca, E., Gilardi, F., Liechti, R., Martin, O., Harshman, K., Delorenzi, M., Desvergne, B., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001442 · Cited by 203 · see citing works
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet
Tognini, P., Murakami, M., Liu, Y., Eckel‐Mahan, K. L., Newman, J. C., Verdin, E. M., Baldi, P., & Sassone‐Corsi, P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.015 · Cited by 202 · see citing works
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription
Kim, Y. H., Marhon, S. A., Zhang, Y., Steger, D. J., Won, K., & Lazar, M. A. (2018) · Science · doi:10.1126/science.aao6891 · Cited by 200 · see citing works
Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax3519 · Cited by 201 · see citing works
Circadian Etiology of Type 2 Diabetes Mellitus
Javeed, N., & Matveyenko, A. V. (2018) · Physiology · doi:10.1152/physiol.00003.2018 · Cited by 205 · see citing works
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198 · see citing works
Extensive Oscillatory Gene Expression during C. elegans Larval Development
Hendriks, G., Gaidatzis, D., Aeschimann, F., & Großhans, H. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.013 · Cited by 199 · see citing works
- Authors
- Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Florida State University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Science
- Published
- 2012-10-19
- Volume
- 338
- Issue
- 6105
- Pages
- 349-354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3694775
- OpenAlex
- W2091531174
- Cited by
- 1,464
- References
- 80
- Citations by year
- 2026: 72 · 2025: 99 · 2024: 93 · 2023: 97 · 2022: 121 · 2021: 112 · 2020: 158 · 2019: 105 · 2018: 109 · 2017: 97 · 2016: 111 · 2015: 102 · 2014: 102 · 2013: 72 · 2012: 13
- FWCI
- 41.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Drug Abuse (F32DA024556)
- National Institute of Neurological Disorders and Stroke (R01NS053616)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, transcriptional feedback loop, clocks, Bmal1, period gene, RNA polymerase II recruitment, chromatin remodeling, transcription factor binding, de novo transcription, post-transcriptional regulation, mouse liver, chromatin state
- MeSH terms
- Animals, Chromatin, Enhancer Elements, Genetic, Histones, Liver, Male, Mice, Inbred C57BL, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Transcriptional Activation, Gene Expression Profiling, DNA, Intergenic, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Genetic Loci, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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