Cited by 61Liver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseNutritional Studies and Diet

Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

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Simancas-Racines, Daniel, Annunziata, Giuseppe, Verde, Ludovica, Fascì-Spurio, Federica, Reytor-González, Claudia, Muscogiuri, Giovanna, Frias-Toral, Evelyn, Barrea, Luigi·2025·Current Obesity Reports

Abstract

PURPOSE OF REVIEW: This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine the effectiveness of specific nutritional strategies in preventing and treating this obesity-linked liver disease. RECENT FINDINGS: Emerging evidence underscores the benefits of the Mediterranean diet, low-carbohydrate diets, and intermittent fasting in reducing liver fat, improving insulin sensitivity, and mitigating inflammation. Supplementing with vitamin E, omega-3 fatty acids, and silymarin can potentially reduce liver fibrosis and promote liver health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, and nutraceutical supplementation. Integrating these strategies with lifestyle modifications, including regular physical activity, offers a comprehensive approach to improving metabolic and liver outcomes in patients with MASLD. Further research is needed to refine and personalize these therapeutic interventions.

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  • In states of dysbiosis, increased intestinal permeability can facilitate translocation of endotoxins into the portal circulation, thereby exacerbating liver inflammation, insulin resistance, and metabolic dysfunction and contributing to diseases such as fatty liver disease, dyslipidemia, or metabolic syndrome.

    “In states of dysbiosis, increased intestinal permeability can facilitate the translocation of endotoxins into the portal circulation, thereby exacerbating liver inflammation, insulin resistance, and metabolic dysfunction and contributing to the development or progression of diseases such as fatty liver disease, dyslipidemia, or metabolic syndrome [94][95][96][97].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [96]

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Authors
Simancas-Racines, D., Annunziata, G., Verde, L., Fascì-Spurio, F., Reytor-González, C., Muscogiuri, G., Frias-Toral, E., & Barrea, L.
Affiliations
  • Pegaso University (IT)
  • University of Naples Federico II (IT)
  • Ospedale dell' Angelo (IT)
  • Universidad UTE (EC)
  • Federico II University Hospital (IT)
Venue
Current Obesity Reports
Published
2025-01-11
Volume
14
Issue
1
Pages
7-7
ISSN
2162-4968 (ISSN-L)
OpenAlex
W4406241721
Cited by
61
References
126
Citations by year
2026: 26 · 2025: 35
FWCI
9.37
Type
journal article
Language
en
Open access
Locations
  • Current Obesity Reports (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
medical nutrition therapy, non-alcoholic fatty liver disease, obesity, Mediterranean diet, low-carbohydrate diet, intermittent fasting, insulin sensitivity, liver fibrosis, vitamin E, omega-3 fatty acids, silymarin, nutraceutical supplementation, caloric restriction, physical activity, inflammation
MeSH terms
Humans, Insulin Resistance, Obesity, Fatty Acids, Omega-3, Dietary Supplements, Caloric Restriction, Diet, Mediterranean, Nutrition Therapy, Diet, Carbohydrate-Restricted, Non-alcoholic Fatty Liver Disease

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