The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of 11 epidemiological studies

Hayat, Umar; Siddiqui, Ali A.; Okut, Hayrettin; Afroz, Saba; Tasleem, Syed; Haris, Ahmed

doi:10.1016/j.aohep.2020.08.071

Cited by 105Coffee research and impactsLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of 11 epidemiological studies

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Hayat, Umar, Siddiqui, Ali A., Okut, Hayrettin, Afroz, Saba, Tasleem, Syed, Haris, Ahmed·2021·Annals of Hepatology

DOI 10.1016/j.aohep.2020.08.071

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Abstract

INTRODUCTION AND OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a widespread chronic liver disease. It is considered a multifactorial disorder that can progress to liver fibrosis and cause a worldwide public health concern. Coffee consumption may have a protective impact on NAFLD and liver fibrosis. However, the evidence from the previous studies is inconsistent. This meta-analysis summarizes available literature. MATERIALS AND METHODS: This study comprises two meta-analyses. The first meta-analysis summarizes the effect of coffee consumption on NAFLD in those who did or did not drink coffee. The second analysis compares the risk of liver fibrosis development between NAFLD patients who did or did not drink coffee. Pooled risk ratios (RR) and confidence intervals (CI) of observational studies were estimated. RESULTS: Of the total collected 321 articles, 11 met our eligibility criteria to be included in the analysis. The risk of NAFLD among those who drank coffee compared to those who did not was significantly lower with a pooled RR value of 0.77 (95% CI 0.60-0.98). Moreover, we also found a significantly reduced risk of liver fibrosis in those who drink coffee than those who did not drink in the NAFLD patients with the relative risk (RR) of 0.68 (95% CI 0.68-0.79). CONCLUSIONS: Regular coffee consumption is significantly associated with a reduced risk of NAFLD. It is also significantly associated with decreased risk of liver fibrosis development in already diagnosed NAFLD patients. Although coffee consumption may be considered an essential preventive measure for NAFLD, this subject needs further epidemiological studies.

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In a meta-analysis of various types of observational studies, the risk of MASLD and fibrosis was lower among those who drank coffee compared to those who did not. The results were stronger and more consistent for fibrosis than for steatosis.
“In a meta-analysis of various types of observational studies, the risk of MASLD and fi brosis was lower among those who drank coffee compared to those who did not. The results were stronger and more consistent for fi brosis than for steatosis. 338”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [338]

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Authors: Hayat, U., Siddiqui, A. A., Okut, H., Afroz, S., Tasleem, S., & Haris, A.
Affiliations: University of Kansas (US)
Loma Linda University Medical Center (US)
Wesley Medical Center (US)
Baylor College of Medicine (US)
Corresponding author: Hayat, Umar
ORCID: Hayat, Umar
Okut, Hayrettin
Tasleem, Syed
Venue: Annals of Hepatology
Publisher: Elsevier BV
Published: 2021-01
Volume: 20
Pages: 100254
ISSN: 1665-2681 (ISSN-L)
DOI: 10.1016/j.aohep.2020.08.071
OpenAlex: W3085297822
Cited by: 105
References: 42
Citations by year: 2026: 11 · 2025: 31 · 2024: 15 · 2023: 21 · 2022: 14 · 2021: 12 · 2020: 1
FWCI: 1.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Annals of Hepatology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: coffee consumption, non-alcoholic fatty liver disease, liver fibrosis
MeSH terms: Coffee, Drinking Behavior, Humans, Liver Cirrhosis, Non-alcoholic Fatty Liver Disease

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The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of 11 epidemiological studies

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