The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Clinical Trials Gap for Adolescents and Young Adults with Cancer: Recent Progress and Conceptual Framework for Continued Research
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, the recurrence rate for osteosarcoma patients remains high even after treatment [275].”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [275]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smith, A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00075 · Cited by 214
Challenges in the recruitment of adolescents and young adults to cancer clinical trials
Burke, M. E., Albritton, K., & Marina, N. (2007) · Cancer · doi:10.1002/cncr.23060 · Cited by 181
Flagged first, then by citations
Research works printed but not linked: 40
- Centers for Disease Control and Prevention. Cancer survivors—United States, 2007. MMWE Morb Mortal Wkly Rep. 2011;60(9):269–72.
- Bleyer WA, Tejeda H, Murphy SB, et al. National cancer clinical trials: children have equal access; adolescents do not. J Adol Health. 1997;21(6):366–73. · DOI
- Albritton K, Bleyer WA. The management of cancer in the older adolescent. Eur J Cancer. 2003;39(18):2584–99. · DOI
- Bleyer A, Montello M, Budd T, Saxman S. National survival trends of young adults with sarcoma: lack of progress is associated with lack of clinical trial participation. Cancer. 2005;103(9):1891–7. · DOI
- Adolescent and Young Adult Progress Review Group: National Cancer Institute and LiveStrong Young Adult Alliance. Closing the gap: research and care imperatives for adolescents and young adults with cancer. Bethesda: National Institutes of Health; 2006. NIH Publication 06-6067.
- Bleyer A. Young adult oncology: the patients and their survival challenges. CA Cancer J Clin. 2007;57(4):242–55. · DOI
- Tricoli JV, Seibel NL, Blair DG, et al. Unique characteristics of adolescent and young adult acute lymphoblastic leukemia, breast cancer, and colon cancer. J Natl Cancer Inst. 2011;103(8):628–35. · DOI
- Perez-Andreu V, Roberts KG, Xu H, et al. A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Blood. 2014;. doi: 10.1182/blood-2014-09-595744 . · DOI
- • Canner J, Alonzo TA, Franklin J et al. Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children’s Oncology Group. Cancer. 2013;119(23):4162–9. This paper reports significantly greater treatment-related mortality for older adolescents treated for acute myeloid leukemia. · DOI
- Veal GJ, Hartford CM, Stewart CF. Clinical pharmacology in the adolescent oncology patient. J Clin Oncol. 2010;28(32):4790–9. · DOI
- • Bhatia S, Landier W, Shanqquan M et al. Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the Children’s Oncology Group. J Clin Oncol. 2012;30(17):2094–101. This study determined that adolescents undergoing treatment for ALL were significantly less likely to be adherent taking oral chemotherapy and more likely to experience leukemic relapse compared with younger children. · DOI
- Martin S, Ulrich C, Munsell M, et al. Delays in cancer diagnosis in underinsured young adults and older adolescents. Oncologist. 2007;12(7):816–24. · DOI
- Pollock BH, Krischer JP, Vietti TJ. Interval between symptom onset and diagnosis of pediatric solid tumors. J Pediatr. 1991;119(5):725–32. · DOI
- Parsons HM, Schmidt S, Harlan LC, et al. Young and uninsured: insurance patterns of recently diagnosed adolescent and young adult cancer survivors in the AYA HOPE study. Cancer. 2014;120(15):2352–60. · DOI
- Krailo M, Bernstein L, Sullivan-Halley J, Hammond GD. Patterns of enrollment on cooperative group studies: an analysis of trends from the Los Angeles County Cancer Surveillance Program. Cancer. 1993;71(10 Suppl):3325–30. · DOI
- Liu L, Krailo M, Reaman GH, et al. Childhood cancer patients’ access to cooperative group cancer programs: a population-based study. Cancer. 2003;97(5):1339–45. · DOI
- Fern LA, Whelan J. Recruitment of adolescents and young adults to cancer clinical trials—international comparisons, barriers, and implications. Semin Oncol. 2010;37(2):e1–8. · DOI
- Shaw PH, Ritchey AK. Different rates of clinical trial enrollment between adolescents and young adults aged 15-22 years old and children under 15 years old with cancer at a children’s hospital. J Pediatr Hematol Oncol. 2007;29(12):811–4. · DOI
- Downs-Canner S, Shaw PH. A comparison of clinical trial enrollment between adolescent and young adult (AYA) oncology patients treated at affiliated adult and pediatric oncology centers. J Pediatr Hematol Oncol. 2009;31(12):927–9. · DOI
- Parsons HM, Harlan LC, Seibel NL, et al. Clinical trial participation and time to treatment among adolescents and young adults with cancer: does age at diagnosis make a difference? J Clin Oncol. 2011;29(30):4045–53. · DOI
- Collins C, Freyer DR. Deficits in clinical trial enrollment among adolescents and young adults with cancer treated at an academic medical center. Pediatr Blood Cancer. 2014;61(S2):S344.
- Bleyer A, Ulrich C, Martin S. Young adults, cancer, health insurance, socioeconomic status, and the patient protection and affordable care act. Cancer. 2012;118(24):6018–21. · DOI
- Ferrari A, Montello M, Budd T, Bleyer A. The challenges of clinical trials for adolescents and young adults with cancer. Pediatr Blood Cancer. 2008;50(5 Suppl):1101–4. · DOI
- Albritton KH, Wiggins CH, Nelson HE, Weeks JC. Site of oncologic specialty care for older adolescents in Utah. J Clin Oncol. 2007;25(29):4616–21. · DOI
- Yeager ND, Hoshaw-Woodard S, Ruymann FB, Termuhlen A. Patterns of care among adolescents with malignancy in Ohio. J Pediatr Hematol Oncol. 2006;28(1):17–22.
- • Wolfson J, Sun CL, Tongiun K et al. Impact of treatment site in adolescents and young adult with central nervous system tumors. J Natl Cancer Inst. 2014;106(8). doi: 10.1093/jnci/dju166 . This study found that AYAs with CNS tumors fare better when treated at NCI-designated Comprehensive Cancer Centers but are less likely to receive care at those sites due to identified referral barriers. · DOI
- • Buchanan ND, Block R, Smith AW, Tai E. Psychosocial barriers and facilitators to clinical trial enrollment and adherence for adolescents with cancer. Pediatr. 2014;133(S3):S123–30. This is a lucid, comprehensive review of current research about psychosocial factors influencing cancer clinical trial participation by older adolescents. · DOI
- •• Fern LA, Lewandowski JA, Coxon KM, Whelan J. Available, accessible, aware, appropriate, and acceptable: a strategy to improve participation of teenagers and young adults in cancer trials. Lancet Oncol. 2014;15(8):e341–50. This paper provides data indicating positive impact of a national-level strategy to overcome age as a barrier in clinical trial development and recruitment in the UK. · DOI
- Institute of Medicine. Implementing a national cancer clinical trials system for the 21st century: workshop summary. Washington: The National Academies Press; 2011.
- National Cancer Institute. NCI Central Institutional Review Board Initiative. Available at: https://ncicirb.org (accessed January 17, 2015).
- Gupta AA, Indelicato DJ. Increasing the number of clinical trials available to adolescents diagnosed with cancer. Pediatr. 2014;133(S3):S114–8. · DOI
- Seibel NL, Hunsberger S, O’Mara AM et al. Adolescent and young adult oncology patient enrollments onto National Cancer Institute-supported trials from 2000–2010. J Clin Oncol. 2014;32(5S):Suppl (Abstract 10058). · DOI
- Albritton KH, Coccia P. Influencing referral of adolescents and young adults with cancer to sites with higher rates of trial enrollment. Pediatrics. 2014;133(S3):S104–8. · DOI
- Felgenhauer J, Hooke MC. Regulatory barriers to clinical trial enrollment of adolescent and young adult oncology patients. Pediatrics. 2014;133(S3):S119–22. · DOI
- Kaplan CP, Nápoles AM, Dohan D, et al. Clinical trial discussion, referral, and recruitment: physician, patient, and system factors. Cancer Causes Control. 2013;24(5):979–88. · DOI
- Siminoff LA, Zhang A, Colabianchi N, et al. Factors that predict the referral of breast cancer patients onto clinical trials by their surgeons and medical oncologists. J Clin Oncol. 2000;18(6):1203–11. · DOI
- •• Shaw PH, Boyiadzis M, Tawbi H et al. Improved clinical trial enrollment in adolescent and young adult (AYA) oncology patients after the establishment of an AYA oncology program uniting pediatric and medical oncology divisions. Cancer. 2012;118(14):3614–7. This study reports data demonstrating how establishing an AYA program may be an effective means for improving clinical trial enrollment of young adults in an academic medical center. · DOI
- Shaw PH, Hayes-Lattin B, Johnson R, Bleyer A. Improving enrollment in clinical trials for adolescents with cancer. Pediatrics. 2014;133(S3):S109–13. · DOI · Paper page
- Read K, Fernandez CV, Gao J, et al. Decision-making by adolescents and parents of children with cancer regarding health research participation. Pediatrics. 2009;124(3):959–65. · DOI
- Freyer DR, Felgenhauer J, Perentesis J. Children’s Oncology Group’s 2013 blueprint for research: adolescent and young adult oncology. Pediatr Blood Cancer. 2013;60(6):1055–8. · DOI
Cited by
Sorted by citations
Emerging role of exosomes in cancer therapy: progress and challenges
Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297
Adolescent and young adult cancers: unmet needs and closing the gaps
Berkman, A. M., Mittal, N., & Roth, M. E. (2023) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001200 · Cited by 50
Sanford, S. D., Beaumont, J. L., Snyder, M. A., Reichek, J., & Salsman, J. M. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-016-3558-7 · Cited by 41
Metadata
- Authors
- Freyer, D. R., & Seibel, N. L.
- Venue
- Current Pediatrics Reports
- Published
- 2015-02-18
- Volume
- 3
- Issue
- 2
- Pages
- 137-145
- ISSN
- 2167-4841
- PMC
- PMC6319956
- Cited by
- 65
- References
- 2
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review