A review of vitamin B12 in dermatology
Abstract
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.
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B vitamins prevent skin aging mainly by preventing skin inflammation and pigmentation.
“B vitamins have been shown to prevent skin aging mainly by preventing skin inflammation and pigmentation [99].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [99]
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- Authors
- Brescoll, J., & Daveluy, S.
- Affiliations
- Henry Ford Hospital (US)
- Wayne State University (US)
- Corresponding author
- Brescoll, Jennifer
- ORCID
- Daveluy, Steven
- Venue
- American Journal of Clinical Dermatology
- Published
- 2015-01-06
- Volume
- 16
- Issue
- 1
- Pages
- 27-33
- ISSN
- 1175-0561 (ISSN-L)
- 1179-1888
- OpenAlex
- W2008276474
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 12 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- American Journal of Clinical Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- vitamin B12, vitamin B12 deficiency, cutaneous manifestations, hyperpigmentation, glossitis, vitiligo, aphthous stomatitis, atopic dermatitis, acne, rosacea, cobalt hypersensitivity, cobalamin metabolism
- MeSH terms
- Animals, Cobalt, Humans, Skin Diseases, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency
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