The DOI matches its Crossref record; 50 of the 52 references it cites were found in a registry or an index.
A Review of Vitamin B12 in Dermatology
Abstract
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“B vitamins have been shown to prevent skin aging mainly by preventing skin inflammation and pigmentation [99].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [99]
Citations
Cites
Stabler, S. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcp1113996 · Cited by 1,224
Savage, D. G., Lindenbaum, J., Stabler, S. P., & Allen, R. H. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90149-x · Cited by 707
Oh, R., & Brown, D. L. (2003) · PubMed · Cited by 468
Leon, C. A., Georges, P., & Zaeeter, W. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1304350 · Cited by 444
Significance of elevated cobalamin (vitamin B12) levels in blood
Ermens, A. A. M., Vlasveld, L. T., & Lindemans, J. W. (2003) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.08.004 · Cited by 246
The pathophysiology of elevated vitamin B12 in clinical practice
Andrès, E., Serraj, K. A., Zhu, J., & Vermorken, A. J. M. (2013) · QJM · doi:10.1093/qjmed/hct051 · Cited by 238
Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism
Coelho, D., Kim, J. C., Miousse, I. R., Fung, S., du Moulin, M., Buers, I., Suormala, T., Burda, P., Frapolli, M., Stucki, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2386 · Cited by 231
Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders
Kozyraki, R., & Cases, O. (2012) · Biochimie · doi:10.1016/j.biochi.2012.11.004 · Cited by 181
Grarup, N., Sulem, P., Sandholt, C. H., Þorleifsson, G., Ahluwalia, T. S., Steinthórsdóttir, V., Bjarnason, H., Gudbjartsson, D. F., Magnússon, Ó. Þ., Sparsø, T., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003530 · Cited by 177
Genetic disorders of vitamin B12metabolism: eight complementation groups – eight genes
Froese, D. S., & Gravel, R. A. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001651 · Cited by 143
Flagged first, then by citations
2 of the 52 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–110 of 110
Vitamina B12: Un agente causal de erupción acneiforme
Enríquez, M. J. E. (2024) · Más Vita · doi:10.47606/acven/mv0222
Investigation of Gait Characteristics and Factors Affecting Gait in Children with Atopic Dermatitis
Sarıkurt, F., Demir, B., Akgöl, G., Kırık, S., Çiçek, D., & Güral, Y. (2024) · Turkish Journal of Dermatology · doi:10.4274/tjd.galenos.2024.29392
Cutaneous pigmentation and sensory ataxia in vitamin B12 deficiency
Garg, S., Behera, B., Thakur, V., & Gowda, S. K. (2025) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.1177/14782715251325580
A hidden deficiency unveiled by hyperpigmentation: a case report of vitamin B12 deficiency
Orolu, A. K., & Ogunlade, T. (2025) · International Journal of Scientific Reports · doi:10.18203/issn.2454-2156.intjscirep20250748
Der Haarzyklus und seine Beziehung zur Ernährung
Trüeb, R. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-72154-0_4
Zhao, X., Lyu, X., Wang, H., Li, Y., Peng, F., & Zhang, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1579531
Bak, R. G., Çetin, C., Kılınç, F., Akbaş, A., & Saraç, G. A. (2025) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2025.2559677
Role of Diet and Supplements in Vitiligo
Hamid, A. B., Turner, K., & Elbuluk, N. (2025) · Updates in clinical dermatology · doi:10.1007/978-3-032-05928-4_9
Mathew, A. R., Buccini, L., Proietti, A., Matteo, G. D., Selita, E., Serangeli, I., Stefanelli, R., Gazzera, E., Mura, F., Mannina, L., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05841-9
Ye, Z., Han, X., Lin, G., Zhou, J., & Wu, Y. (2026) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2026.e00535
Metadata
- Authors
- Brescoll, J., & Daveluy, S.
- Affiliations
- Henry Ford Hospital (US)
- Wayne State University (US)
- Corresponding author
- Brescoll, Jennifer
- ORCID
- Daveluy, Steven
- Venue
- American Journal of Clinical Dermatology
- Published
- 2015-01-06
- Volume
- 16
- Issue
- 1
- Pages
- 27-33
- ISSN
- 1175-0561 (ISSN-L)
- 1179-1888
- OpenAlex
- W2008276474
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 12 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- American Journal of Clinical Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- vitamin B12, vitamin B12 deficiency, cutaneous manifestations, hyperpigmentation, glossitis, vitiligo, aphthous stomatitis, atopic dermatitis, acne, rosacea, cobalt hypersensitivity, cobalamin metabolism
- MeSH terms
- Animals, Cobalt, Humans, Skin Diseases, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
