The DOI matches its Crossref record; 50 of the 52 references it cites were found in a registry or an index.
A Review of Vitamin B12 in Dermatology
Abstract
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.
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“B vitamins have been shown to prevent skin aging mainly by preventing skin inflammation and pigmentation [99].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [99]
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Stabler, S. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcp1113996 · Cited by 1,224
Savage, D. G., Lindenbaum, J., Stabler, S. P., & Allen, R. H. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90149-x · Cited by 707
Oh, R., & Brown, D. L. (2003) · PubMed · Cited by 468
Leon, C. A., Georges, P., & Zaeeter, W. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1304350 · Cited by 444
Significance of elevated cobalamin (vitamin B12) levels in blood
Ermens, A. A. M., Vlasveld, L. T., & Lindemans, J. W. (2003) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.08.004 · Cited by 246
The pathophysiology of elevated vitamin B12 in clinical practice
Andrès, E., Serraj, K. A., Zhu, J., & Vermorken, A. J. M. (2013) · QJM · doi:10.1093/qjmed/hct051 · Cited by 238
Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism
Coelho, D., Kim, J. C., Miousse, I. R., Fung, S., du Moulin, M., Buers, I., Suormala, T., Burda, P., Frapolli, M., Stucki, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2386 · Cited by 231
Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders
Kozyraki, R., & Cases, O. (2012) · Biochimie · doi:10.1016/j.biochi.2012.11.004 · Cited by 181
Grarup, N., Sulem, P., Sandholt, C. H., Þorleifsson, G., Ahluwalia, T. S., Steinthórsdóttir, V., Bjarnason, H., Gudbjartsson, D. F., Magnússon, Ó. Þ., Sparsø, T., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003530 · Cited by 177
Genetic disorders of vitamin B12metabolism: eight complementation groups – eight genes
Froese, D. S., & Gravel, R. A. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001651 · Cited by 143
Cited by
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The Roles of Vitamin C in Skin Health.
Pullar, J., Carr, A., & Vissers, M. (2017) · Nutrients · doi:10.3390/nu9080866 · Cited by 756
“Dermatological signs of B vitamin deficiency, for example, include a patchy red rash, seborrhoeic dermatitis and fungal skin and nail infections [9,10].”
BackgroundDiet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231
Decoding Skin Aging: A Review of Mechanisms, Markers, and Modern Therapies
Naharro‐Rodríguez, J., Bacci, S., Hernández‐Bule, M. L., Pérez-González, L. A., & Fernández-Guarino, M. (2025) · Cosmetics · doi:10.3390/cosmetics12040144 · Cited by 98
Park, S., & Bae, J.-H. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.11.011 · Cited by 66
Vitamin deficiencies/hypervitaminosis and the skin
Aşkın, Ö., Uzunçakmak, T. K., Altunkalem, R. N., & Tüzün, Y. (2021) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2021.05.010 · Cited by 62
Metadata
- Authors
- Brescoll, J., & Daveluy, S.
- Affiliations
- Henry Ford Hospital (US)
- Wayne State University (US)
- Corresponding author
- Brescoll, Jennifer
- ORCID
- Daveluy, Steven
- Venue
- American Journal of Clinical Dermatology
- Published
- 2015-01-06
- Volume
- 16
- Issue
- 1
- Pages
- 27-33
- ISSN
- 1175-0561 (ISSN-L)
- 1179-1888
- OpenAlex
- W2008276474
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 12 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- American Journal of Clinical Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- vitamin B12, vitamin B12 deficiency, cutaneous manifestations, hyperpigmentation, glossitis, vitiligo, aphthous stomatitis, atopic dermatitis, acne, rosacea, cobalt hypersensitivity, cobalamin metabolism
- MeSH terms
- Animals, Cobalt, Humans, Skin Diseases, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency
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