Cited by 111Folate and B Vitamins ResearchPorphyrin Metabolism and Disordersmelanin and skin pigmentation

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A Review of Vitamin B12 in Dermatology

Brescoll, Jennifer, Daveluy, Steven·2015·American Journal of Clinical Dermatology

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Abstract

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.

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Authors: Brescoll, J., & Daveluy, S.
Affiliations: Henry Ford Hospital (US)
Wayne State University (US)
Corresponding author: Brescoll, Jennifer
ORCID: Daveluy, Steven
Venue: American Journal of Clinical Dermatology
Publisher: Springer Science and Business Media LLC
Published: 2015-01-06
Volume: 16
Issue: 1
Pages: 27-33
ISSN: 1175-0561 (ISSN-L)
1179-1888
DOI: 10.1007/s40257-014-0107-3
OpenAlex: W2008276474
Cited by: 111
References: 52
Citations by year: 2026: 5 · 2025: 20 · 2024: 12 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 3
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: American Journal of Clinical Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: vitamin B12, vitamin B12 deficiency, cutaneous manifestations, hyperpigmentation, glossitis, vitiligo, aphthous stomatitis, atopic dermatitis, acne, rosacea, cobalt hypersensitivity, cobalamin metabolism
MeSH terms: Animals, Cobalt, Humans, Skin Diseases, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency

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A Review of Vitamin B12 in Dermatology

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