Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders
Open accessAbstract
Depressive disorders are complex, multifactorial disorders that have been traditionally attributed exclusively to neuronal abnormalities. However, recent studies have increased our understanding of the contribution of glial cells—and particularly of oligodendroglia—to the pathogenesis and treatment outcome of depression and stress‐related disorders. This review scrutinizes recent studies focusing on the neurosupportive functions exerted by myelin and oligodendrocyte lineage cells and their disruption in depression and stress‐related disorders. It also illustrates how myelin and oligodendroglia respond to antidepressants and non‐pharmacological treatment alternatives and proposes oligodendroglia‐directed approaches as novel therapeutic options for depressive disorders.
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Microglia have abundant peroxisome content and express abundant ALDP in normal microglia in human and mouse brains.
“Their peroxisome content is abundant [166,253,315], and they express abundant ALDP in normal microglia in human and mouse brains [156].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [315]
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- Authors
- Boda, E.
- Affiliations
- Neuroscience Institute Cavalieri Ottolenghi (IT)
- Corresponding author
- Boda, Enrica
- ORCID
- Boda, Enrica
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2019-12-20
- Volume
- 53
- Issue
- 1
- Pages
- 281-297
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2984835181
- Cited by
- 80
- References
- 23
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 16 · 2021: 14 · 2020: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Torino (RiLo2018)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- myelin, oligodendrocytes, oligodendroglia, depression, stress-related disorders, glial cells, antidepressants, non-pharmacological treatment, myelin damage
- MeSH terms
- Depression, Myelin Sheath, Neurons, Oligodendroglia, Cell Lineage
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