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Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle
Open accessAbstract
A sedentary lifestyle has been linked to a number of metabolic disorders that have been associated with sub-optimal mitochondrial characteristics and an increased risk of premature death. Endurance training can induce an increase in mitochondrial content and/or mitochondrial functional qualities, which are associated with improved health and well-being and longer life expectancy. It is therefore important to better define how manipulating key parameters of an endurance training intervention can influence the content and functionality of the mitochondrial pool. This review focuses on mitochondrial changes taking place following a series of exercise sessions (training-induced mitochondrial adaptations), providing an in-depth analysis of the effects of exercise intensity and training volume on changes in mitochondrial protein synthesis, mitochondrial content and mitochondrial respiratory function. We provide evidence that manipulation of different exercise training variables promotes specific and diverse mitochondrial adaptations. Specifically, we report that training volume may be a critical factor affecting changes in mitochondrial content, whereas relative exercise intensity is an important determinant of changes in mitochondrial respiratory function. As a consequence, a dissociation between training-induced changes in mitochondrial content and mitochondrial respiratory function is often observed. We also provide evidence that exercise-induced changes are not necessarily predictive of training-induced adaptations, we propose possible explanations for the above discrepancies and suggestions for future research.
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“Training volume plays a crucial role in influencing changes in mitochondrial content, whereas relative exercise intensity is a key factor in determining alterations in mitochondrial respiratory function [68].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [68]
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Metadata
- Authors
- Granata, C., Jamnick, N. A., & Bishop, D. J.
- Affiliations
- Monash University (AU)
- Victoria University (AU)
- Edith Cowan University (AU)
- Corresponding author
- Granata, Cesare
- Venue
- Sports Medicine
- Published
- 2018-06-22
- Volume
- 48
- Issue
- 8
- Pages
- 1809-1828
- ISSN
- 0112-1642 (ISSN-L)
- 1179-2035
- OpenAlex
- W2809197837
- Cited by
- 247
- References
- 177
- Citations by year
- 2026: 27 · 2025: 37 · 2024: 30 · 2023: 33 · 2022: 34 · 2021: 32 · 2020: 23 · 2019: 25 · 2018: 6
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
- vuir.vu.edu.au
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Research Online (Edith Cowan University) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- mitochondrial biogenesis, mitochondrial content, mitochondrial respiratory function, endurance training, skeletal muscle, exercise intensity, training volume, mitochondrial translation, sedentary lifestyle, training effects
- MeSH terms
- Adaptation, Physiological, Exercise Test, Humans, Mitochondria, Muscle, Oxygen Consumption, Exercise, Muscle, Skeletal, Cell Respiration, Physical Conditioning, Human
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