Cited by 247Cardiovascular and exercise physiologyMitochondrial Function and PathologyExercise and Physiological Responses

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Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

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Granata, Cesare, Jamnick, Nicholas A., Bishop, David J.·2018·Sports Medicine

DOI 10.1007/s40279-018-0936-y

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Abstract

A sedentary lifestyle has been linked to a number of metabolic disorders that have been associated with sub-optimal mitochondrial characteristics and an increased risk of premature death. Endurance training can induce an increase in mitochondrial content and/or mitochondrial functional qualities, which are associated with improved health and well-being and longer life expectancy. It is therefore important to better define how manipulating key parameters of an endurance training intervention can influence the content and functionality of the mitochondrial pool. This review focuses on mitochondrial changes taking place following a series of exercise sessions (training-induced mitochondrial adaptations), providing an in-depth analysis of the effects of exercise intensity and training volume on changes in mitochondrial protein synthesis, mitochondrial content and mitochondrial respiratory function. We provide evidence that manipulation of different exercise training variables promotes specific and diverse mitochondrial adaptations. Specifically, we report that training volume may be a critical factor affecting changes in mitochondrial content, whereas relative exercise intensity is an important determinant of changes in mitochondrial respiratory function. As a consequence, a dissociation between training-induced changes in mitochondrial content and mitochondrial respiratory function is often observed. We also provide evidence that exercise-induced changes are not necessarily predictive of training-induced adaptations, we propose possible explanations for the above discrepancies and suggestions for future research.

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Authors: Granata, C., Jamnick, N. A., & Bishop, D. J.
Affiliations: Monash University (AU)
Victoria University (AU)
Edith Cowan University (AU)
Corresponding author: Granata, Cesare
ORCID: Granata, Cesare
Jamnick, Nicholas A.
Bishop, David J.
Venue: Sports Medicine
Publisher: Springer Science and Business Media LLC
Published: 2018-06-22
Volume: 48
Issue: 8
Pages: 1809-1828
ISSN: 0112-1642 (ISSN-L)
1179-2035
DOI: 10.1007/s40279-018-0936-y
OpenAlex: W2809197837
Cited by: 247
References: 177
Citations by year: 2026: 27 · 2025: 37 · 2024: 30 · 2023: 33 · 2022: 34 · 2021: 32 · 2020: 23 · 2019: 25 · 2018: 6
FWCI: 5.03
Type: journal article
Language: en
Open access: green
vuir.vu.edu.au
Licence: www.springer.com/tdm (tdm)
Locations: Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Research Online (Edith Cowan University) (submittedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: mitochondrial biogenesis, mitochondrial content, mitochondrial respiratory function, endurance training, skeletal muscle, exercise intensity, training volume, mitochondrial translation, sedentary lifestyle, training effects
MeSH terms: Adaptation, Physiological, Exercise Test, Humans, Mitochondria, Muscle, Oxygen Consumption, Exercise, Muscle, Skeletal, Cell Respiration, Physical Conditioning, Human

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Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

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