Cited by 121Stress Responses and CortisolAdipokines, Inflammation, and Metabolic DiseasesTryptophan and brain disorders

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Systematic Review of the Evidence of a Relationship Between Chronic Psychosocial Stress and C-Reactive Protein

Johnson, Timothy V., Abbasi, Ammara, Master, Viraj A.·2013·Molecular Diagnosis & Therapy

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Abstract

Introduction C-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified several social, economic, demographic, and psychological factors that contribute to baseline inflammation. Psychosocial stress represents a significant contributor to baseline inflammation. Given the importance of understanding background drivers of CRP levels, we conducted this review to assess the impact of chronic psychosocial stress on CRP levels.Methods Medline was searched through February 2013 for human studies examining CRP levels with respect to chronic psychosocial stress.Results The initial search identified 587 articles from which 129 potentially appropriate articles were reviewed. Of these 129 articles, 41 articles were included in the review. These studies were published between 2003 and 2013. Of these studies, 6 analyzed employment stress, 2 analyzed unemployment stress, 6 analyzed burnout and vital exhaustion, 6 analyzed caregiver stress, 3 analyzed interpersonal stress, 17 analyzed socioeconomic position, and 2 analyzed discrimination.Conclusion We conclude that psychosocial stress significantly impacts CRP and should be considered when interpreting the meaning of CRP elevations.

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Authors: Johnson, T. V., Abbasi, A., & Master, V. A.
Affiliations: Thomas Jefferson University (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Johnson, Timothy V.
ORCID: Master, Viraj A.
Venue: Molecular Diagnosis & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2013-04-25
Volume: 17
Issue: 3
Pages: 147-164
ISSN: 1177-1062 (ISSN-L)
1179-2000
DOI: 10.1007/s40291-013-0026-7
OpenAlex: W1966668500
Cited by: 121
References: 120
Citations by year: 2026: 7 · 2025: 18 · 2024: 20 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 1
FWCI: 0.41
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular Diagnosis & Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: chronic psychosocial stress, C-reactive protein, acute phase proteins, occupational stress, burnout, vital exhaustion, caregiver stress, interpersonal stress, socioeconomic position, discrimination
MeSH terms: Adult, Age Factors, Analysis of Variance, C-Reactive Protein, Conflict, Psychological, Female, Humans, Inflammation, Male, Middle Aged, Sex Factors, Social Environment, Socioeconomic Factors, Stress, Psychological

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Systematic Review of the Evidence of a Relationship Between Chronic Psychosocial Stress and C-Reactive Protein

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