The DOI matches its Crossref record; 117 of the 120 references it cites were found in a registry or an index.
Systematic Review of the Evidence of a Relationship Between Chronic Psychosocial Stress and C-Reactive Protein
Abstract
Introduction C-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified several social, economic, demographic, and psychological factors that contribute to baseline inflammation. Psychosocial stress represents a significant contributor to baseline inflammation. Given the importance of understanding background drivers of CRP levels, we conducted this review to assess the impact of chronic psychosocial stress on CRP levels.Methods Medline was searched through February 2013 for human studies examining CRP levels with respect to chronic psychosocial stress.Results The initial search identified 587 articles from which 129 potentially appropriate articles were reviewed. Of these 129 articles, 41 articles were included in the review. These studies were published between 2003 and 2013. Of these studies, 6 analyzed employment stress, 2 analyzed unemployment stress, 6 analyzed burnout and vital exhaustion, 6 analyzed caregiver stress, 3 analyzed interpersonal stress, 17 analyzed socioeconomic position, and 2 analyzed discrimination.Conclusion We conclude that psychosocial stress significantly impacts CRP and should be considered when interpreting the meaning of CRP elevations.
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“The reason to focus on inflammation is that chronic psychological stress, such as experienced by LSEs relative to HSEs when using social media, can lead to elevated levels of systemic inflammation over time (Johnson et al., 2013; Nersesian et al., 2018; Walker et al., 2019).”
From Social media use and systemic inflammation: The moderating role of self-esteem (2021) · cites this paper as Johnson et al., 2013
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Lagraauw, H. M., Kuiper, J., & Bot, I. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.007 · Cited by 289
Physiological biomarkers of chronic stress: A systematic review.
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MECHANISMS IN ENDOCRINOLOGYEndocrine and immunological aspects of burnout: a narrative review
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The emotional stress and risk of ischemic stroke
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Metadata
- Authors
- Johnson, T. V., Abbasi, A., & Master, V. A.
- Affiliations
- Thomas Jefferson University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Johnson, Timothy V.
- ORCID
- Master, Viraj A.
- Venue
- Molecular Diagnosis & Therapy
- Published
- 2013-04-25
- Volume
- 17
- Issue
- 3
- Pages
- 147-164
- ISSN
- 1177-1062 (ISSN-L)
- 1179-2000
- OpenAlex
- W1966668500
- Cited by
- 121
- References
- 120
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 20 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Diagnosis & Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- chronic psychosocial stress, C-reactive protein, acute phase proteins, occupational stress, burnout, vital exhaustion, caregiver stress, interpersonal stress, socioeconomic position, discrimination
- MeSH terms
- Adult, Age Factors, Analysis of Variance, C-Reactive Protein, Conflict, Psychological, Female, Humans, Inflammation, Male, Middle Aged, Sex Factors, Social Environment, Socioeconomic Factors, Stress, Psychological
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