Cited by 137Physical Activity and HealthTreatment of Major DepressionBipolar Disorder and Treatment

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Physical Exercise for Treatment of Mood Disorders: A Critical Review

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Hearing, C. M., Chang, W. C., Szuhany, K. L., Deckersbach, T., Nierenberg, A. A., Sylvia, Louisa G.·2016·Current Behavioral Neuroscience Reports

DOI 10.1007/s40473-016-0089-yPMC PMC5423723

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Abstract

Purpose of the review The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population. Exercise may not only mitigate the increased risk of cardiovascular disease, but could also potentially improve the long term outcomes of mood disorders.Recent findings We conducted a literature review on the impact of exercise on mood disorders and associated comorbid conditions as well as possible biological mechanisms. We found that exercise impacts both the physical health parameters of mood disorders as well as mental health outcomes. Exercise also positively impacts conditions frequently comorbid with mood disorders (i.e. anxiety, pain, and insomnia). There are multiple candidate biomarkers for exercise, with brain-derived neurotrophic factor and oxidative stress as two main promising components of exercise's anti-depressant effect.Summary Exercise appears to be a promising adjunct treatment for mood disorders. We conclude with recommendations for future research of exercise as an adjunct intervention for mood disorders.

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Authors: Hearing, C. M., Chang, W. C., Szuhany, K. L., Deckersbach, T., Nierenberg, A. A., & Sylvia, L. G.
Affiliations: Massachusetts General Hospital (US)
Boston University (US)
Harvard University (US)
Corresponding author: Sylvia, Louisa G.
ORCID: Szuhany, K. L.
Deckersbach, T.
Nierenberg, A. A.
Sylvia, Louisa G.
Venue: Current Behavioral Neuroscience Reports
Publisher: Springer Science and Business Media LLC
Published: 2016-10-14
Volume: 3
Issue: 4
Pages: 350-359
ISSN: 2196-2979 (ISSN-L)
DOI: 10.1007/s40473-016-0089-y
PMC: PMC5423723
OpenAlex: W2530458945
Cited by: 137
References: 131
Citations by year: 2026: 10 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 13 · 2021: 23 · 2020: 13 · 2019: 21 · 2018: 11 · 2017: 8
FWCI: 10.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Current Behavioral Neuroscience Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health
National Alliance for Research on Schizophrenia and Depression
Patient-Centered Outcomes Research Institute
American Foundation for Suicide Prevention
Takeda
Agency for Healthcare Research and Quality
Brain and Behavior Research Foundation
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: physical activity, mood disorders, major depressive disorder, bipolar disorder, adjunctive therapy, comorbidities, cardiovascular risk, obesity, brain-derived neurotrophic factor, oxidative stress, exercise biomarkers, anxiety, pain, insomnia, antidepressant mechanism

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Physical Exercise for Treatment of Mood Disorders: A Critical Review

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