The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Candida auris Infection and Biofilm Formation: Going Beyond the Surface
Open accessAbstract
Purpose of Review: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy. Recent Findings: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices. Summary: Here, we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
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“with biofilm formation enhancing its adhesive capacity and colonization efficiency9–11”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
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“The cell wall adhesin Als4 plays a central role in biofilm formation in C. auris and is required for adhesion to both biotic and abiotic surfaces11,14,17,50,52.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
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“Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
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“Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
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Cites
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662
Satoh, K., Makimura, K., Hasumi, Y., Nishiyama, Y., Uchida, K., & Yamaguchi, H. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2008.00083.x · Cited by 1,381
Biofilm Formation: A Clinically Relevant Microbiological Process
Donlan, R. M. (2001) · Clinical Infectious Diseases · doi:10.1086/322972 · Cited by 1,343
Candida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055
Pfaller, M. A., Diekema, D. J., Turnidge, J. D., Castanheira, M., & Jones, R. N. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy358 · Cited by 825
First hospital outbreak of the globally emerging Candida auris in a European hospital
Schelenz, S., Hagen, F., Rhodes, J. L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Trimlett, R., Meis, J. F., et al. (2016) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-016-0132-5 · Cited by 768
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F., Hoyer, L. L., Douglas, L., & Ghannoum, M. A. (2001) · Journal of Dental Research · doi:10.1177/00220345010800031101 · Cited by 588
Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx480 · Cited by 577
Candida biofilms on implanted biomaterials: a clinically significant problem
Ramage, G., MartÃnez, J. P., & López-Ribot, J. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00117.x · Cited by 575
Research works printed but not linked: 1
- Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun. 2003;71(8):4333–40. https://doi.org/10.1128/iai.71.8.4333-4340.2003. · DOI · Paper page
Cited by
Sorted by citations
Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species
Czajka, K. M., Venkataraman, K., Brabant-Kirwan, D., Santi, S. A., Verschoor, C. P., Appanna, V. D., Singh, R. I., Saunders, D., & Tharmalingam, S. (2023) · Cells · doi:10.3390/cells12222655 · Cited by 207
Diagnosis and Treatment of Invasive Candidiasis
Barantsevich, N. E., & Barantsevich, E. P. (2022) · Antibiotics · doi:10.3390/antibiotics11060718 · Cited by 209
Barber, C. A., Crank, K. C., Papp, K., Innes, G. K., Schmitz, B. W., Chavez, J., Rossi, A., & Gerrity, D. W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07763 · Cited by 95
Candida auris: A Quick Review on Identification, Current Treatments, and Challenges
Černáková, L., Roudbary, M., Brás, S., Tafaj, S., & Rodrigues, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094470 · Cited by 85
de Melo, C. C., de Sousa, B. R., da Costa, G. L., Oliveira, M. M. E., & de Lima-Neto, R. G. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1033707 · Cited by 61
Metadata
- Authors
- Horton, M. V., & Nett, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Nett, Jeniel E.
- ORCID
- Nett, Jeniel E.
- Venue
- Current Clinical Microbiology Reports
- Published
- 2020-07-17
- Volume
- 7
- Issue
- 3
- Pages
- 51-56
- ISSN
- 2196-5471 (ISSN-L)
- PMC
- PMC7654955
- OpenAlex
- W3042454077
- Cited by
- 132
- References
- 47
- Citations by year
- 2026: 30 · 2025: 23 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 8 · 2020: 1
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Clinical Microbiology Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Doris Duke Charitable Foundation (2017074)
- National Institute of Allergy and Infectious Diseases (R21AI159583, R01AI145939)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- Candida auris, biofilm formation, antifungal resistance, nosocomial transmission, invasive candidiasis, skin colonization, biomedical implants, desiccation tolerance, emerging fungal pathogens
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