Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital

Satoh, Kazuo; Makimura, Koichi; Hasumi, Yayoi; Nishiyama, Yayoi; Uchida, Katsuhisa; Yamaguchi, Hideyo

doi:10.1111/j.1348-0421.2008.00083.x

Cited by 1,381Yeasts and Rust Fungi StudiesAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases

Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital

Open access

Satoh, Kazuo, Makimura, Koichi, Hasumi, Yayoi, Nishiyama, Yayoi, Uchida, Katsuhisa, Yamaguchi, Hideyo·2009·Microbiology and Immunology

DOI 10.1111/j.1348-0421.2008.00083.x

Open this paper in CoChat — free account Open PDF

Abstract

A single strain of a novel ascomycetous yeast species belonging to the genus Candida was isolated from the external ear canal of an inpatient in a Japanese hospital. Analyses of the 26S rDNA D1/D2 domain, nuclear ribosomal DNA ITS region sequences, and chemotaxonomic studies indicated that this strain represents a new species with a close phylogenetic relationship to Candida ruelliae and Candida haemulonii in the Metschnikowiaceae clade. This strain grew well at 40 °C, but showed slow and weak growth at 42 °C. The taxonomic description of Candida auris sp. nov. is proposed (type strain JCM15448 T = CBS10913 T = DSM21092 T ).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1348-0421.2008.00083.x

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

C. auris was first described in 2009 and has since been reported in approximately 30 countries, including the United States.
“C. auris, which was first described in 2009 (21) and has since been reported in approximately 30 countries, including the United States (22).”
From Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016 (2019) · cites this paper as [21]
C. auris seems to quickly develop resistance or tolerance to echinocandins and polyenes, leaving few treatment choices.
“C. auris appears to rapidly acquire resistance or tolerance to echinocandins as well polyenes1,42, leaving few, if any, treatment options.”
From Drug resistance and tolerance in fungi. (2020) · cites this paper as [42]
The Results and Discussion (page unavailable) describe antifungal susceptibility for a single C. auris isolate, but do not report resistance developing over time. Table 1 (page unavailable) lists susceptibility results for other drug classes, not echinocandins or polyenes. Searches for rapid acquisition of resistance, echinocandins, polyenes, and treatment options found no passage supporting the claim. (LLM, conf=0.76)
Experimental — accuracy not yet measured
C. auris isolates have been implicated in nosocomial outbreaks worldwide, with 5 distinct clades classified by region of independent emergence.
“C. auris isolates have been implicated in nosocomial outbreaks worldwide, with 5 distinct clades classified by region of independent emergence.”
From Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris : Results from a Phase 2 Trial (2023) · cites this paper as [4]
Candida auris is an emerging multidrug-resistant pathogen of global concern, responsible for outbreaks on six continents and commonly resistant to antifungals.
“Candida auris is an emerging multidrug-resistant pathogen of global concern, known to be responsible for outbreaks on six continents and to be commonly resistant to antifungals.”
From Mutations in TAC1B : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris (2020) · cites this paper as [1]
Most C. auris isolates cannot grow on glycerol or ethanol media as the primary carbon source.
“Due to the inability of most C. auris isolates to grow on glycerol or ethanol media as the primary carbon source [50], we could not evaluate the impact of LNP on the growth of C. auris with both media.”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris (2024) · cites this paper as [50]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,962 · see citing works
Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics
White, T. J., Bruns, T., Lee, S., & Taylor, J. (1990) · PCR Protocols · doi:10.1016/b978-0-12-372180-8.50042-1 · Cited by 36,648 · see citing works
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J. T., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,734 · see citing works
PCR protocols — A guide to methods and applications
U.G. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90252-7 · Cited by 11,750 · see citing works
The Yeasts. A Taxonomic Study
Kurtzman, C. P., & Lodder, J. (1972) · Mycologia · doi:10.2307/3758036 · Cited by 3,441 · see citing works
Methods for the isolation, maintenance and identification of yeasts
Yarrow, D. (1998) · Elsevier eBooks · doi:10.1016/b978-044481312-1/50014-9 · Cited by 951 · see citing works
Candida Berkhout
Meyer, S. A., Payne, R. W., & Yarrow, D. (1998) · Elsevier eBooks · doi:10.1016/b978-044481312-1/50069-1 · Cited by 76 · see citing works
Differentiation of Candida albicans and Candida dubliniensis Using a Single-Enzyme PCR-RFLP Method
Mirhendi, H., Makimura, K., Zomorodian, K., Maeda, N., Ohshima, T., & Yamaguchi, H. (2005) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2005.235 · Cited by 74 · see citing works
Self-citation
Candida pseudohaemulonii Sp. Nov., an Amphotericin B‐ and Azole‐Resistant Yeast Species, Isolated from the Blood of a Patient from Thailand
Sugita, T., Takashima, M., Poonwan, N., & Mekha, N. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03816.x · Cited by 54 · see citing works
Candida alocasiicola sp. nov., Candida hainanensis sp. nov., Candida heveicola sp. nov. and Candida musiphila sp. nov., novel anamorphic, ascomycetous yeast species isolated from plants
Wang, S., Jia, J., & Bai, F. (2008) · Antonie van Leeuwenhoek · doi:10.1007/s10482-008-9238-y · Cited by 34 · see citing works
Candida gelsemii sp. nov., a yeast of the Metschnikowiaceae clade isolated from nectar of the poisonous Carolina jessamine
Manson, J. S., Lachance, M., & Thomson, J. D. (2007) · Antonie van Leeuwenhoek · doi:10.1007/s10482-006-9132-4 · Cited by 32 · see citing works
Candida ruelliae sp. nov., a novel yeast species isolated from flowers of Ruellia sp. (Acanthaceae)
Saluja, P., & Prasad, G. S. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2008.00372.x · Cited by 30 · see citing works
A case of pulmonary aspergilloma molecular biological identification and typing of the isolates from antemortem sputa and autopsy fungus ball
Sugita, C., Makimura, K., Murakami, A., et al. (2003) · Mycoses · doi:10.1046/j.1439-0507.2003.00850.x · Cited by 21 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662 · see citing works
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works
First hospital outbreak of the globally emerging Candida auris in a European hospital
Schelenz, S., Hagen, F., Rhodes, J. L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Trimlett, R., Meis, J. F., et al. (2016) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-016-0132-5 · Cited by 768 · see citing works
Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Drug resistance and tolerance in fungi.
Berman, J., & Krysan, D. J. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0322-2 · Cited by 654 · see citing works
Candida auris: Epidemiology, biology, antifungal resistance, and virulence
Du, H., Bing, J., Hu, T., Ennis, C. L., Nobile, C. J., & Huang, G. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008921 · Cited by 609 · see citing works
A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance
Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx480 · Cited by 577 · see citing works
Changes in the epidemiological landscape of invasive candidiasis
Lamoth, F., Lockhart, S. R., Berkow, E. L., & Calandra, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx444 · Cited by 547 · see citing works
Fluconazole resistance in Candida species: a current perspective
Berkow, E., & Lockhart, S. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s118892 · Cited by 542 · see citing works
Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic health care surface.
Welsh, R. M., Bentz, M. L., Shams, A., Houston, H., Lyons, A., Rose, L. J., & Litvintseva, A. P. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00921-17 · Cited by 499 · see citing works
Candida auris : The recent emergence of a multidrug-resistant fungal pathogen
Forsberg, K., Woodworth, K., Walters, M., Berkow, E. L., Jackson, B., Chiller, T., & Vallabhaneni, S. (2019) · Medical Mycology · doi:10.1093/mmy/myy054 · Cited by 421 · see citing works
Candida auris: an Emerging Fungal Pathogen
Spivak, E. S., & Hanson, K. E. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01588-17 · Cited by 393 · see citing works
The emerging pathogen Candida auris: growth phenotype, virulence factors, activity of antifungals, and effect of SCY-078, a novel glucan synthesis inhibitor, on growth morphology and biofilm formation
Larkin, E., Hager, C., Chandra, J., Mukherjee, P. K., Retuerto, M., Salem, I., Long, L., Isham, N., Kovanda, L., Borroto-Esoda, K., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02396-16 · Cited by 395 · see citing works
Multidrug-resistant endemic clonal strain of Candida auris in India
Chowdhary, A., Anil Kumar, V., Sharma, C., Prakash, A., Agarwal, K., Babu, R., Dinesh, K. R., Karim, S., Singh, S. K., Hagen, F., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-2027-1 · Cited by 373 · see citing works
Climate change and the emergence of fungal pathogens
Nnadi, N. E., & Carter, D. A. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009503 · Cited by 373 · see citing works
Global epidemiology of emerging Candida auris
Rhodes, J., & Fisher, M. C. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.05.008 · Cited by 315 · see citing works
Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus — United States, May 2013–August 2016
Vallabhaneni, S., Kallen, A., Tsay, S., Chow, N., Welsh, R., Kerins, J., Kemble, S. K., Pacilli, M., Black, S. R., Landon, E., et al. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6544e1 · Cited by 302 · see citing works
Multidrug-Resistant Candida haemulonii and C. auris , Tel Aviv, Israel
Ben-Ami, R., Berman, J., Novikov, A., Bash, E., Shachor-Meyouhas, Y., Zakin, S., Maor, Y., Tarabia, J., Schechner, V., Adler, A., et al. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2302.161486 · Cited by 297 · see citing works
Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey.
Chow, N. A., Gade, L., Tsay, S. V., Forsberg, K., Greenko, J. A., Southwick, K. L., Barrett, P. M., Kerins, J. L., Lockhart, S. R., Chiller, T. M., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30597-8 · Cited by 289 · see citing works
Candida auris in Healthcare Facilities, New York, USA, 2013–2017
Adams, E., Quinn, M., Tsay, S., Poirot, E., Chaturvedi, S., Southwick, K., Greenko, J., Fernandez, R., Kallen, A., Vallabhaneni, S., et al. (2018) · Emerging Infectious Diseases · doi:10.3201/eid2410.180649 · Cited by 284 · see citing works
Comparison of EUCAST and CLSI Reference Microdilution MICs of Eight Antifungal Compounds for Candida auris and Associated Tentative Epidemiological Cutoff Values
Arendrup, M. C., Prakash, A., Meletiadis, J., Sharma, C., & Chowdhary, A. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00485-17 · Cited by 270 · see citing works
Candida auris–Associated Candidemia, South Africa
Magobo, R. E., Corcoran, C., Seetharam, S., & Govender, N. P. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2007.131765 · Cited by 259 · see citing works
Candida auris: epidemiology, diagnosis, pathogenesis, antifungal susceptibility, and infection control measures to combat the spread of infections in healthcare facilities
Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris
Kordalewska, M., Lee, A., Park, S., Berrio, I., Chowdhary, A., Zhao, Y., & Perlin, D. S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00238-18 · Cited by 247 · see citing works
Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus—United States, May 2013–August 2016
Vallabhaneni, S., Kallen, A., Tsay, S., Chow, N., Welsh, R., Kerins, J., Kemble, S. K., Pacilli, M., Black, S. R., Landon, E., et al. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14121 · Cited by 247 · see citing works
Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris
Chatterjee, S., Alampalli, S. V., Nageshan, R. K., Chettiar, S. T., Joshi, S., & Tatu, U. S. (2015) · BMC Genomics · doi:10.1186/s12864-015-1863-z · Cited by 247 · see citing works
Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris
Rhodes, J., Abdolrasouli, A., Farrer, R. A., Cuomo, C. A., Aanensen, D. M., Armstrong-James, D., Fisher, M. C., & Schelenz, S. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0045-x · Cited by 246 · see citing works
Environmental Isolation of Candida auris from the Coastal Wetlands of Andaman Islands, India
Arora, P., Singh, P., Wang, Y., Yadav, A., Pawar, K., Singh, A., Padmavati, G., Xu, J., & Chowdhary, A. (2021) · mBio · doi:10.1128/mbio.03181-20 · Cited by 223 · see citing works
Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance
Carolus, H., Pierson, S., Muñoz, J. F., Subotić, A., Cruz, R. B., Cuomo, C. A., & Van Dijck, P. (2021) · mBio · doi:10.1128/mbio.03333-20 · Cited by 211 · see citing works
Multidrug-resistant Candida auris: ‘New kid on the block’ in hospital-associated infections?
Chowdhary, A., Voss, A., & Meis, J. F. (2016) · Journal of Hospital Infection · doi:10.1016/j.jhin.2016.08.004 · Cited by 214 · see citing works
Mutations in TAC1B : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris
Rybak, J. M., Muñoz, J. F., Barker, K. S., Parker, J. E., Esquivel, B. D., Berkow, E. L., Lockhart, S. R., Gade, L., Palmer, G. E., White, T. C., et al. (2020) · mBio · doi:10.1128/mbio.00365-20 · Cited by 202 · see citing works
Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
Sharma, C., Kumar, N., Pandey, R., Meis, J. F., & Chowdhary, A. (2016) · New Microbes and New Infections · doi:10.1016/j.nmni.2016.07.003 · Cited by 202 · see citing works
Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016
Toda, M., Williams, S. R., Berkow, E. L., Farley, M. M., Harrison, L. H., Bonner, L., Marceaux, K. M., Hollick, R., Zhang, A. Y., Schaffner, W., et al. (2019) · MMWR Surveillance Summaries · doi:10.15585/mmwr.ss6808a1 · Cited by 198 · see citing works
“auris, which was first described in 2009 (21) and has since been reported in approximately 30 countries, including the United States (22).”
BackgroundInfluential
The first isolate of Candida auris in China: clinical and biological aspects
Wang, X., Bing, J., Zheng, Q., Zhang, F., Liu, J., Yue, H., Tao, L., Du, H., Wang, Y., Wang, H., et al. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0095-0 · Cited by 191 · see citing works
Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents
Jacobs, S. E., Jacobs, J. L., Dennis, E. K., Taimur, S., Rana, M., Patel, D., Gitman, M., Patel, G., Schaefer, S., Iyer, K., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00053-22 · Cited by 190 · see citing works
Emerging multidrug-resistant Candida species
Colombo, A. L., Júnior, J. N. D. A., & Guinea, J. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000411 · Cited by 177 · see citing works
Candida auris: Disinfectants and Implications for Infection Control
Ku, T. S. N., Walraven, C. J., & Lee, S. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00726 · Cited by 177 · see citing works
Emerging and reemerging fungal infections
Lockhart, S. R., & Guarner, J. (2019) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2019.04.010 · Cited by 169 · see citing works
Confirmation of fifth Candida auris clade by whole genome sequencing
Spruijtenburg, B., Badali, H., Abastabar, M., Mirhendi, H., Khodavaisy, S., Sharifisooraki, J., Taghizadeh Armaki, M., de Groot, T., & Meis, J. F. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2125349 · Cited by 164 · see citing works
Is the superbug fungus really so scary? A systematic review and meta-analysis of global epidemiology and mortality of Candida auris
Chen, J., Tian, S., Han, X., Chu, Y., Wang, Q., Zhou, B., & Shang, H. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05543-0 · Cited by 159 · see citing works
Candida auris Genetics and Emergence
Chowdhary, A., Jain, K., & Chauhan, N. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032521-015858 · Cited by 158 · see citing works
Abrogation of Triazole Resistance upon Deletion of CDR1 in a Clinical Isolate of Candida auris
Rybak, J. M., Doorley, L. A., Nishimoto, A. T., Barker, K. S., Palmer, G. E., & Rogers, P. D. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00057-19 · Cited by 141 · see citing works
The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens
Arastehfar, A., Lass-Flörl, C., Garcia-Rubio, R., Daneshnia, F., Ilkit, M., Boekhout, T., Gabaldon, T., & Perlin, D. S. (2020) · Journal of Fungi · doi:10.3390/jof6030138 · Cited by 145 · see citing works
Candida auris : An emerging multidrug-resistant pathogen
Sears, D., & Schwartz, B. S. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.08.017 · Cited by 146 · see citing works
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies
Huang, X., Hurabielle, C., Drummond, R. A., Bouladoux, N., Desai, J. V., Sim, C. K., Belkaid, Y., Lionakis, M. S., & Segre, J. A. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2020.12.002 · Cited by 144 · see citing works
In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris
Hager, C. L., Larkin, E. L., Long, L., Zohra Abidi, F., Shaw, K. J., & Ghannoum, M. A. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02319-17 · Cited by 139 · see citing works
Candida Auris, An Agent of Hospital-Associated Outbreaks: Which Challenging Issues Do We Need to Have in Mind?
Sabino, R., Veríssimo, C., Pereira, Á. A., & Antunes, F. (2020) · Microorganisms · doi:10.3390/microorganisms8020181 · Cited by 133 · see citing works
Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance
Kim, S. H., Iyer, K. R., Pardeshi, L., Muñoz, J. F., Robbins, N., Cuomo, C. A., Wong, K. H., & Cowen, L. E. (2019) · mBio · doi:10.1128/mbio.02529-18 · Cited by 136 · see citing works
Candida auris Infection and Biofilm Formation: Going Beyond the Surface
Horton, M. V., & Nett, J. E. (2020) · Current Clinical Microbiology Reports · doi:10.1007/s40588-020-00143-7 · Cited by 132 · see citing works
Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris
Muñoz, J. F., Welsh, R. M., Shea, T., Batra, D., Gade, L., Howard, D., Rowe, L. A., Meis, J. F., Litvintseva, A. P., & Cuomo, C. A. (2021) · Genetics · doi:10.1093/genetics/iyab029 · Cited by 125 · see citing works
Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?
Rossato, L., & Colombo, A. L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03081 · Cited by 121 · see citing works
In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris
Rybak, J. M., Barker, K. S., Muñoz, J. F., Parker, J. E., Ahmad, S., Mokaddas, E., Abdullah, A., Elhagracy, R. S., Kelly, S. L., Cuomo, C. A., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2021.11.024 · Cited by 120 · see citing works
Inhibition of Candida auris Biofilm Formation on Medical and Environmental Surfaces by Silver Nanoparticles
Lara, H. H., Ixtepan-Turrent, L., Jose Yacaman, M., & Lopez-Ribot, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20708 · Cited by 116 · see citing works
Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait
Khan, Z., Ahmad, S., Al-Sweih, N., Joseph, L., Alfouzan, W., & Asadzadeh, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195743 · Cited by 109 · see citing works
The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
Rybak, J. M., Cuomo, C. A., & David Rogers, P. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102208 · Cited by 113 · see citing works
Innate immune responses against the fungal pathogen Candida auris
Wang, Y., Zou, Y., Chen, X., Li, H., Yin, Z., Zhang, B., Xu, Y., Zhang, Y., Zhang, R., Huang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31201-x · Cited by 107 · see citing works
Control of Candida auris in healthcare institutions: Outcome of an International Society for Antimicrobial Chemotherapy expert meeting
Kenters, N., Kiernan, M., Chowdhary, A., Denning, D. W., Pemán, J., Saris, K., Schelenz, S., Tartari, E., Widmer, A., Meis, J. F., et al. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.08.013 · Cited by 102 · see citing works
Multi-omics Signature of Candida auris , an Emerging and Multidrug-Resistant Pathogen
Zamith-Miranda, D., Heyman, H. M., Cleare, L. G., Couvillion, S. P., Clair, G. C., Bredeweg, E. L., Gacser, A., Nimrichter, L., Nakayasu, E. S., & Nosanchuk, J. D. (2019) · mSystems · doi:10.1128/msystems.00257-19 · Cited by 99 · see citing works
Candida auris : multi-omics signature of an emerging and multidrug-resistant pathogen
Zamith-Miranda, D., Heyman, H. M., Cleare, L. G., Couvillion, S., Clair, G., Bredeweg, E., Gacser, A., Nimrichter, L., Nakayasu, E. S., & Nosanchuk, J. D. (2019) · doi:10.1101/528232 · Cited by 99 · see citing works
Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris : Results from a Phase 2 Trial
Vazquez, J. A., Pappas, P. G., Boffard, K., Paruk, F., Bien, P. A., Tawadrous, M., Ople, E., Wedel, P., Oborska, I., & Hodges, M. R. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01419-22 · Cited by 92 · see citing works
Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains
Santana, D. J., & O’Meara, T. R. (2021) · Nature Communications · doi:10.1038/s41467-021-27545-5 · Cited by 91 · see citing works
ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes
Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Bravo Ruiz, G., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01445 · Cited by 89 · see citing works
Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo
Burrack, L. S., Todd, R. T., Soisangwan, N., Wiederhold, N. P., & Selmecki, A. (2022) · mBio · doi:10.1128/mbio.00842-22 · Cited by 82 · see citing works
First report of sporadic cases of Candida auris in Colombia
Parra-Giraldo, C. M., Valderrama, S. L., Cortes-Fraile, G., Garzón, J. R., Ariza, B. E., Morio, F., Linares-Linares, M. Y., Ceballos-Garzón, A., de la Hoz, A., Hernandez, C., et al. (2018) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2018.01.034 · Cited by 74 · see citing works
Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection
Bing, J., Guan, Z., Zheng, T., Ennis, C. L., Nobile, C. J., Chen, C., Chu, H., & Huang, G. (2024) · Nature Communications · doi:10.1038/s41467-024-46786-8 · Cited by 74 · see citing works
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
Carolus, H., Sofras, D., Boccarella, G., Sephton-Clark, P., Biriukov, V., Cauldron, N. C., Lobo Romero, C., Vergauwen, R., Yazdani, S., Pierson, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01854-z · Cited by 72 · see citing works
Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance
Rybak, J. M., Sharma, C., Doorley, L. A., Barker, K. S., Palmer, G. E., & Rogers, P. D. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01585-21 · Cited by 69 · see citing works
Candida auris: An emerging pathogen “incognito”?
Nett, J. E. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007638 · Cited by 69 · see citing works
Update on the Pathogenesis, Virulence, and Treatment of Candida auris
Watkins, R. R., Gowen, R., Lionakis, M., & Ghannoum, M. (2022) · Pathogens and Immunity · doi:10.20411/pai.v7i2.535 · Cited by 68 · see citing works
Climate change, animals, and Candida auris: insights into the ecological niche of a new species from a One Health approach
Garcia-Bustos, V., Cabañero-Navalon, M. D., Ruiz-Gaitán, A., Salavert, M., Tormo-Mas, M. Á., & Pemán, J. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.03.016 · Cited by 68 · see citing works
Mechanisms of pathogenicity for the emerging fungus Candida auris
Horton, M. V., Holt, A. M., & Nett, J. E. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011843 · Cited by 67 · see citing works
Rapid Detection of ERG11 -Associated Azole Resistance and FKS -Associated Echinocandin Resistance in Candida auris
Hou, X., Lee, A., Jiménez-Ortigosa, C., Kordalewska, M., Perlin, D. S., & Zhao, Y. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01811-18 · Cited by 66 · see citing works
Deciphering the Mrr1/Mdr1 Pathway in Azole Resistance of Candida auris
Li, J., Coste, A. T., Bachmann, D., Sanglard, D., & Lamoth, F. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00067-22 · Cited by 59 · see citing works
Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection
Sharma, D., Paul, R. A., Rudramurthy, S. M., Kashyap, N., Bhattacharya, S., Soman, R., Shankarnarayan, S. A., Chavan, D., Singh, S., Das, P., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01652-21 · Cited by 60 · see citing works
Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections
Vila, T., Montelongo-Jauregui, D., Ahmed, H., Puthran, T., Sultan, A. S., & Jabra-Rizk, M. A. (2020) · mSphere · doi:10.1128/msphere.00760-20 · Cited by 58 · see citing works
Activity of free and liposome-encapsulated essential oil from Lavandula angustifolia against persister-derived biofilm of Candida auris
de Alteriis, E., Maione, A., Falanga, A., Bellavita, R., Galdiero, S., Albarano, L., Salvatore, M. M., Galdiero, E., & Guida, M. (2021) · Antibiotics · doi:10.3390/antibiotics11010026 · Cited by 54 · see citing works
Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR
Dickwella Widanage, M. C., Singh, K., Li, J., Yarava, J. R., Scott, F. J., Xu, Y., Gow, N. A. R., Mentink-Vigier, F., Wang, P., Lamoth, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61678-1 · Cited by 51 · see citing works
Unique Cell Surface Mannan of Yeast Pathogen Candida auris with Selective Binding to IgG
Yan, L., Xia, K., Yu, Y., Miliakos, A., Chaturvedi, S., Zhang, F., Chen, S., Chaturvedi, V., & Linhardt, R. J. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00450 · Cited by 47 · see citing works
In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris
Rudramurthy, S. M., Colley, T., Abdolrasouli, A., Ashman, J., Dhaliwal, M., Kaur, H., Armstrong-James, D., Strong, P., Rapeport, G., Schelenz, S., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz280 · Cited by 44 · see citing works
Comparative Transcriptomics Reveal Possible Mechanisms of Amphotericin B Resistance in Candida auris
Shivarathri, R., Jenull, S., Chauhan, M., Singh, A., Mazumdar, R., Chowdhary, A., Kuchler, K., & Chauhan, N. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02276-21 · Cited by 41 · see citing works
Caspofungin-resistance in Candida auris is cell wall-dependent phenotype and potential prevention by zinc oxide nanoparticles
Fayed, B., Jayakumar, M. N., & Soliman, S. S. M. (2021) · Medical Mycology · doi:10.1093/mmy/myab059 · Cited by 41 · see citing works
Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris
Narayanan, A., Kumar, P., Chauhan, A., Kumar, M., Yadav, K., Banerjee, A., Sharma, R. D., Rudramurthy, S. M., Chakrabarti, A., Sanyal, K., et al. (2022) · mBio · doi:10.1128/mbio.03052-22 · Cited by 35 · see citing works
Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris
Jenull, S., Shivarathri, R., Tsymala, I., Penninger, P., Trinh, P.-C., Nogueira, F., Chauhan, M., Singh, A., Petryshyn, A., Stoiber, A., et al. (2022) · mBio · doi:10.1128/mbio.00799-22 · Cited by 32 · see citing works
Transcriptome Signatures Predict Phenotypic Variations of Candida auris
Jenull, S., Tscherner, M., Kashko, N., Shivarathri, R., Stoiber, A., Chauhan, M., Petryshyn, A., Chauhan, N., & Kuchler, K. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.662563 · Cited by 32 · see citing works
Adhesin Als4112 promotes Candida auris skin colonization through interactions with keratinocytes and extracellular matrix proteins
Zhao, G., Lyu, J., Veniaminova, N. A., Zarnowski, R., Mattos, E., Johnson, C. J., Quintanilla, D., Hautau, H., Hold, L. A., Xu, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60876-1 · Cited by 32 · see citing works
Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles
Chan, W., Chow, F. W.-N., Tsang, C.-C., Liu, X., Yao, W., Chan, T. T.-Y., Siu, G. K.-H., Ho, A. Y.-M., Luk, K. S., Lau, S. K.-P., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2098058 · Cited by 31 · see citing works
Biofilms and beyond: Expanding echinocandin utility
Larkin, E. L., Dharmaiah, S., & Ghannoum, M. A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx451 · Cited by 31 · see citing works
Transcriptional and translational landscape of Candida auris in response to caspofungin
Zamith-Miranda, D., Amatuzzi, R. F., Munhoz da Rocha, I. F., Martins, S. T., Lucena, A. C. R., Vieira, A. Z., Trentin, G., Almeida, F., Rodrigues, M. L., Nakayasu, E. S., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.09.007 · Cited by 29 · see citing works
Native human and mouse skin infection models to study Candida auris-host interactions
Seiser, S., Arzani, H., Ayub, T., Phan-Canh, T., Staud, C., Worda, C., Kuchler, K., & Elbe-Bürger, A. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2023.105234 · Cited by 29 · see citing works
Pharmacokinetics and Pharmacodynamics of Ibrexafungerp
McCarthy, M. W. (2022) · Drugs in R&D · doi:10.1007/s40268-021-00376-x · Cited by 28 · see citing works
The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris
Junker, K., Bravo Ruiz, G., Lorenz, A., Walker, L., Gow, N. A. R., & Wendland, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-33199-z · Cited by 27 · see citing works
Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
Hetta, H. F., Ramadan, Y. N., Al-Kadmy, I. M. S., Ellah, N. H. A., Shbibe, L., & Battah, B. (2023) · Pathogens · doi:10.3390/pathogens12081033 · Cited by 24 · see citing works
The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence
Shivarathri, R., Chauhan, M., Datta, A., Das, D., Karuli, A., Aptekmann, A., Jenull, S., Kuchler, K., Thangamani, S., Chowdhary, A., et al. (2024) · mBio · doi:10.1128/mbio.02748-24 · Cited by 22 · see citing works
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Khan, A., Moni, S. S., Ali, M., Mohan, S., Jan, H., Rasool, S., Kamal, M. A., Alshahrani, S., Halawi, M., & Alhazmi, H. A. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467215666220304143332 · Cited by 17 · see citing works
A Comparative Transcriptome Between Anti-drug Sensitive and Resistant Candida auris in China
Zhou, W., Li, X., Lin, Y., Yan, W., Jiang, S., Huang, X., Yang, X., Qiao, D., & Li, N. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.708009 · Cited by 16 · see citing works
Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris
Salama, E. A., Elgammal, Y., Wijeratne, A., Lanman, N. A., Utturkar, S. M., Farhangian, A., Li, J., Meunier, B., Hazbun, T. R., & Seleem, M. N. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2322649 · Cited by 16 · see citing works
Multi‐Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance
Chauhan, A., Carolus, H., Sofras, D., Kumar, M., Kumar, P., Nair, R., Narayanan, A., Yadav, K., Ali, B., Biriukov, V., et al. (2025) · Molecular Microbiology · doi:10.1111/mmi.15379 · Cited by 16 · see citing works
A single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris
Deng, Y., Xu, M., Li, S., Bing, J., Zheng, Q., Huang, G., Liao, W., Pan, W., & Tao, L. (2024) · PLOS Pathogens · doi:10.1371/journal.ppat.1012362 · Cited by 16 · see citing works
Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Rabaan, A. A., Eljaaly, K., Alfouzan, W. A., Mutair, A. A., Alhumaid, S., Alfaraj, A. H., Aldawood, Y., Alsaleh, A. A., Albayat, H., Azmi, R. A., et al. (2023) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2022.12.012 · Cited by 14 · see citing works
Candida auris metabolism and growth preferences in physiologically relevant skin-like conditions
Nicklas, J. P., Deming, C., Lee-Lin, S., Conlan, S., Shen, Z., Blaustein, R. A., & Segre, J. A. (2026) · mBio · doi:10.1128/mbio.03117-25 · Cited by 8 · see citing works

Authors: Satoh, K., Makimura, K., Hasumi, Y., Nishiyama, Y., Uchida, K., & Yamaguchi, H.
Affiliations: Japan Health Sciences Foundation (JP)
Teikyo University (JP)
Corresponding author: Makimura, Koichi
ORCID: Satoh, Kazuo
Makimura, Koichi
Venue: Microbiology and Immunology
Publisher: Wiley
Published: 2009-01
Volume: 53
Issue: 1
Pages: 41-44
ISSN: 0385-5600 (ISSN-L)
1348-0421
DOI: 10.1111/j.1348-0421.2008.00083.x
OpenAlex: W1987095367
Cited by: 1,381
References: 13
Citations by year: 2026: 170 · 2025: 173 · 2024: 164 · 2023: 172 · 2022: 143 · 2021: 133 · 2020: 143 · 2019: 104 · 2018: 80 · 2017: 62 · 2016: 16 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 1
FWCI: 0.94
Type: journal article
Language: en
Update notices: correction (2018-03-25)
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14 d)
Locations: Microbiology and Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
Keywords: Candida auris, new yeast species, Candida, ascomycetous yeasts, external auditory canal, otitis externa, Candida haemulonii, yeast taxonomy, ITS region, chemotaxonomy, thermal growth
MeSH terms: Aged, Candida, Candidiasis, DNA, Fungal, DNA, Ribosomal, Ear Canal, Female, Hospitalization, Humans, Japan, Molecular Sequence Data, Phylogeny, Mycological Typing Techniques, DNA, Ribosomal Spacer

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks