Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence
Open accessAbstract
Surfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multidrug-resistant yeast which can survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentrations of sodium hypochlorite and remained viable 14 days post treatment. The ability of C. auris to adhere to and persist on environmental surfaces emphasizes our need to better understand the biology of this fungal pathogen.
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Aggregating strains demonstrate higher biofilm-forming capacity.
“Aggregation seems to play an important role in C. auris biofilm formation, since aggregating strains demonstrated higher biofilm-forming capacity, which was associated with distinct transcriptomic profiles compared to the non-aggregative strains (13, 23, 25, 57).”
From Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i> (2024) · cites this paper as [57]
Cites
Kean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G. (2018) · mSphere · doi:10.1128/msphere.00334-18 · Cited by 220 · see citing works
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Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Santana, D. J., Anku, J. A. E., Zhao, G., Zarnowski, R., Johnson, C. J., Hautau, H., Visser, N. D., Ibrahim, A. S., Andes, D., Nett, J. E., et al. (2023) · Science · doi:10.1126/science.adf8972 · Cited by 142 · see citing works
Lara, H. H., Ixtepan-Turrent, L., Jose Yacaman, M., & Lopez-Ribot, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20708 · Cited by 116 · see citing works
Santana, D. J., & O’Meara, T. R. (2021) · Nature Communications · doi:10.1038/s41467-021-27545-5 · Cited by 91 · see citing works
de Alteriis, E., Maione, A., Falanga, A., Bellavita, R., Galdiero, S., Albarano, L., Salvatore, M. M., Galdiero, E., & Guida, M. (2021) · Antibiotics · doi:10.3390/antibiotics11010026 · Cited by 54 · see citing works
Zhao, G., Lyu, J., Veniaminova, N. A., Zarnowski, R., Mattos, E., Johnson, C. J., Quintanilla, D., Hautau, H., Hold, L. A., Xu, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60876-1 · Cited by 32 · see citing works
“To further explore the impact of collagen coating, we assessed its effect not only on the initial adhesion of C. auris but also on its subsequent bio fi lm formation, a crucial factor in the persistence of infections and resistance to treatment 12,48 – 51 .”
Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i>
Louvet, M., Li, J., Brandalise, D., Bachmann, D., Sala de Oyanguren, F., Labes, D., Jacquier, N., Genoud, C., Mucciolo, A., Coste, A. T., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01531-24 · Cited by 20 · see citing works
Cha, H., Won, D., & Bahn, Y.-S. (2025) · mBio · doi:10.1128/mbio.02475-23 · Cited by 19 · see citing works
Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Rabaan, A. A., Eljaaly, K., Alfouzan, W. A., Mutair, A. A., Alhumaid, S., Alfaraj, A. H., Aldawood, Y., Alsaleh, A. A., Albayat, H., Azmi, R. A., et al. (2023) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2022.12.012 · Cited by 14 · see citing works
- Authors
- Short, B., Brown, J., Delaney, C., Sherry, L., Williams, C., Ramage, G., & Kean, R.
- Affiliations
- University of Glasgow (GB)
- University of the West of Scotland (GB)
- Glasgow Caledonian University (GB)
- Corresponding author
- Kean, R.
- Venue
- Journal of Hospital Infection
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 103
- Issue
- 1
- Pages
- 92-96
- ISSN
- 0195-6701 (ISSN-L)
- OpenAlex
- W2950095546
- Cited by
- 87
- References
- 1
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 12 · 2023: 12 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 3
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Hospital Infection (publishedVersion)
- PubMed (publishedVersion)
- The UWS Academic Portal (University of the West of Scotland) (publishedVersion, cc-by-nc-nd)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- ResearchOnline (Glasgow Caledonian University) (submittedVersion, cc-by-nc-nd)
- Funders
- European Society of Clinical Microbiology and Infectious Diseases
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida auris, biofilm formation, environmental persistence, cell aggregation, disinfectant resistance, multidrug resistance, nosocomial transmission
- MeSH terms
- Candida, Disinfectants, Environmental Microbiology, Sodium Hypochlorite, Biofilms, Microbial Viability
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