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Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy

Liu, Yajun, Chen, Qian·2020·Current Molecular Biology Reports
DOI 10.1007/s40610-020-00141-0PMC PMC8011589
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  • Senescent cells are a broad category of damaged cells that enter growth arrest and cause inflammation and stem cell exhaustion.

    “In mammals, one candidate for x is senescent cells—a broad category of damaged cells that enter growth arrest and cause inflammation and stem cell exhaustion56,57.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [57]

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Research works printed but not linked: 67

  1. Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019;4:22. https://doi.org/10.1038/s41536-019-0083-6. · DOI · Paper page
  2. Zhou X, Hong Y, Zhang H, Li X. Mesenchymal stem cell senescence and rejuvenation: current status and challenges. Front Cell Dev Biol. 2020;8(364). https://doi.org/10.3389/fcell.2020.00364. · DOI
  3. Squillaro T, Peluso G, Galderisi U. Clinical trials with mesenchymal stem cells: an update. Cell Transplant. 2016;25(5):829–48. https://doi.org/10.3727/096368915x689622. · DOI
  4. Dimmeler S, Leri A. Aging and disease as modifiers of efficacy of cell therapy. Circ Res. 2008;102(11):1319–30. https://doi.org/10.1161/circresaha.108.175943. · DOI · Paper page
  5. Li Y, Wu Q, Wang Y, Li L, Bu H, Bao J. Senescence of mesenchymal stem cells (review). Int J Mol Med. 2017;39(4):775–82. https://doi.org/10.3892/ijmm.2017.2912. · DOI
  6. Neri S, Borzì RM. Molecular mechanisms contributing to mesenchymal stromal cell aging. Biomolecules. 2020;10(2). https://doi.org/10.3390/biom10020340. · DOI
  7. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621. https://doi.org/10.1016/0014-4827(61)90192-6. · DOI · Paper page
  8. Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008;7(3):335–43. https://doi.org/10.1111/j.1474-9726.2008.00377.x. · DOI
  9. • Franzen J, Zirkel A, Blake J, Rath B, Benes V, Papantonis A, et al. Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells. Aging Cell. 2017;16(1):183–91. https://doi.org/10.1111/acel.12544. This work provides evidence of epigenetic modification of DNA associated with aging of MSCs. · DOI
  10. Andrzejewska A, Lukomska B, Janowski M. Concise review: Mesenchymal stem cells: from roots to boost. Stem Cells. 2019;37(7):855–64. https://doi.org/10.1002/stem.3016. · DOI
  11. • Hu N, Gao Y, Jayasuriya CT, Liu W, Du H, Ding J, et al. Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR. Arthritis Res Ther. 2019;21(1):167. https://doi.org/10.1186/s13075-019-1949-0. This work demonstrates a microRNA dependent mechanism of alteration of differentiation potentials in senescent MSCs. · DOI
  12. Reitinger S, Schimke M, Klepsch S, de Sneeuw S, Yani SL, Gaßner R, et al. Systemic impact molds mesenchymal stromal/stem cell aging. Transfus Apher Sci. 2015;52(3):285–9. https://doi.org/10.1016/j.transci.2015.04.008. · DOI
  13. Akyurekli C, Le Y, Richardson RB, Fergusson D, Tay J, Allan DS. A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev Rep. 2015;11(1):150–60. https://doi.org/10.1007/s12015-014-9545-9. · DOI
  14. Xie H, Wang Z, Zhang L, Lei Q, Zhao A, Wang H, et al. Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications. PeerJ. 2016;4:e2040. https://doi.org/10.7717/peerj.2040. · DOI
  15. Yuan QL, Zhang YG, Chen Q. Mesenchymal stem cell (MSC)-derived extracellular vesicles: potential therapeutics as MSC trophic mediators in regenerative medicine. Anat Rec (Hoboken). 2020;303(6):1735–42. https://doi.org/10.1002/ar.24186. · DOI
  16. Lei Q, Liu T, Gao F, Xie H, Sun L, Zhao A, et al. Microvesicles as potential biomarkers for the identification of senescence in human Mesenchymal stem cells. Theranostics. 2017;7(10):2673–89. https://doi.org/10.7150/thno.18915. · DOI
  17. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol. 2000;35(8):927–45. https://doi.org/10.1016/s0531-5565(00)00180-7. · DOI · Paper page
  18. Stolzing A, Coleman N, Scutt A. Glucose-induced replicative senescence in mesenchymal stem cells. Rejuvenation Res. 2006;9(1):31–5. https://doi.org/10.1089/rej.2006.9.31. · DOI
  19. Gharibi B, Farzadi S, Ghuman M, Hughes FJ. Inhibition of Akt/mTOR attenuates age-related changes in Mesenchymal stem cells. Stem Cells. 2014;32(8):2256–66. https://doi.org/10.1002/stem.1709. · DOI
  20. Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med. 2014;20(8):870–80. https://doi.org/10.1038/nm.3651. · DOI · Paper page
  21. Goldring MB. Articular cartilage degradation in osteoarthritis. HSS J. 2012;8(1):7–9. https://doi.org/10.1007/s11420-011-9250-z. · DOI
  22. Li G, Yin J, Gao J, Cheng TS, Pavlos NJ, Zhang C, et al. Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes. Arthritis Res Ther. 2013;15(6):223. https://doi.org/10.1186/ar4405. · DOI
  23. Alsalameh S, Amin R, Gemba T, Lotz M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum. 2004;50(5):1522–32. https://doi.org/10.1002/art.20269. · DOI
  24. Hattori S, Oxford C, Reddi AH. Identification of superficial zone articular chondrocyte stem/progenitor cells. Biochem Biophys Res Commun. 2007;358(1):99–103. https://doi.org/10.1016/j.bbrc.2007.04.142. · DOI
  25. Grogan SP, Miyaki S, Asahara H, D'Lima DD, Lotz MK. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther. 2009;11(3):R85. https://doi.org/10.1186/ar2719. · DOI
  26. Fickert S, Fiedler J, Brenner RE. Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers. Arthritis Res Ther. 2004;6(5):R422–32. https://doi.org/10.1186/ar1210. · DOI
  27. Su X, Zuo W, Wu Z, Chen J, Wu N, Ma P, et al. CD146 as a new marker for an increased chondroprogenitor cell sub-population in the later stages of osteoarthritis. J Orthop Res. 2015;33(1):84–91. https://doi.org/10.1002/jor.22731. · DOI
  28. Jayasuriya CT, Hu N, Li J, Lemme N, Terek R, Ehrlich MG, et al. Molecular characterization of mesenchymal stem cells in human osteoarthritis cartilage reveals contribution to the OA phenotype. Sci Rep. 2018;8(1):7044. https://doi.org/10.1038/s41598-018-25395-8. · DOI
  29. • Malaise O, Tachikart Y, Constantinides M, Mumme M, Ferreira-Lopez R, Noack S, et al. Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. Aging (Albany NY). 2019;11(20):9128–46. https://doi.org/10.18632/aging.102379. This study demonstrates a paracrine mechanism for the senescent MSCs in synovium and bone marrow to induce cartilage degeneration. · DOI
  30. Martinez FJ, Collard HR, Pardo A, Raghu G, Richeldi L, Selman M, et al. Idiopathic pulmonary fibrosis. Nat Rev Dis Primers. 2017;3:17074. https://doi.org/10.1038/nrdp.2017.74. · DOI · Paper page
  31. Cárdenes N, Álvarez D, Sellarés J, Peng Y, Corey C, Wecht S, et al. Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis. Stem Cell Res Ther. 2018;9(1):257. https://doi.org/10.1186/s13287-018-0970-6. · DOI
  32. Vicinanza C, Aquila I, Scalise M, Cristiano F, Marino F, Cianflone E, et al. Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification. Cell Death Differ. 2017;24(12):2101–16. https://doi.org/10.1038/cdd.2017.130. · DOI
  33. Castaldi A, Dodia RM, Orogo AM, Zambrano CM, Najor RH, Gustafsson ÅB, et al. Decline in cellular function of aged mouse c-kit(+) cardiac progenitor cells. J Physiol. 2017;595(19):6249–62. https://doi.org/10.1113/jp274775. · DOI
  34. Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, et al. Aged-senescent cells contribute to impaired heart regeneration. Aging Cell. 2019;18(3):e12931. https://doi.org/10.1111/acel.12931. · DOI · Paper page
  35. •• Nicaise AM, Wagstaff LJ, Willis CM, Paisie C, Chandok H, Robson P, et al. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. Proc Natl Acad Sci U S A. 2019;116(18):9030–9. https://doi.org/10.1073/pnas.1818348116. A nice study to demonstrate the contribution of senescent neural stem cells to multiple sclerosis. · DOI
  36. • Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X, et al. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem Cell Res Ther. 2019;10(1):218. https://doi.org/10.1186/s13287-019-1334-6. This work demonstrates molecular mechanisms of cell senescence in long term culture of MSCs. · DOI
  37. Burhans WC, Weinberger M. DNA replication stress, genome instability and aging. Nucleic Acids Res. 2007;35(22):7545–56. https://doi.org/10.1093/nar/gkm1059. · DOI · Paper page
  38. Chen X, Wang L, Hou J, Li J, Chen L, Xia J, et al. Study on the dynamic biological characteristics of human bone marrow Mesenchymal stem cell senescence. Stem Cells Int. 2019;2019:9271595–9. https://doi.org/10.1155/2019/9271595. · DOI
  39. Jeong SG, Cho GW. Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells. Biochem Biophys Res Commun. 2015;460(4):971–6. https://doi.org/10.1016/j.bbrc.2015.03.136. · DOI
  40. Lai TP, Wright WE, Shay JW. Comparison of telomere length measurement methods. Philos Trans R Soc Lond Ser B Biol Sci. 2018;373(1741):20160451. https://doi.org/10.1098/rstb.2016.0451. · DOI
  41. Nadeau S, Cheng A, Colmegna I, Rodier F. Quantifying senescence-associated phenotypes in primary multipotent Mesenchymal stromal cell cultures. Methods Mol Biol. 2019;2045:93–105. https://doi.org/10.1007/7651_2019_217. · DOI
  42. Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, et al. Mesenchymal stromal cells deficient in autophagy proteins are susceptible to oxidative injury and mitochondrial dysfunction. Am J Respir Cell Mol Biol. 2017;56(3):300–9. https://doi.org/10.1165/rcmb.2016-0061OC. · DOI
  43. Revuelta M, Matheu A. Autophagy in stem cell aging. Aging Cell. 2017;16(5):912–5. https://doi.org/10.1111/acel.12655. · DOI
  44. Eckhart L, Tschachler E, Gruber F. Autophagic control of skin aging. Front Cell Dev Biol. 2019;7:143. https://doi.org/10.3389/fcell.2019.00143. · DOI
  45. Mortensen M, Watson AS, Simon AK. Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation. Autophagy. 2011;7(9):1069–70. https://doi.org/10.4161/auto.7.9.15886. · DOI
  46. Huang X, Zhang H, Liang X, Hong Y, Mao M, Han Q, et al. Adipose-derived Mesenchymal stem cells isolated from patients with abdominal aortic aneurysm exhibit senescence phenomena. Oxidative Med Cell Longev. 2019;2019:1305049–12. https://doi.org/10.1155/2019/1305049. · DOI
  47. Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. The clinical potential of Senolytic drugs. J Am Geriatr Soc. 2017;65(10):2297–301. https://doi.org/10.1111/jgs.14969. · DOI · Paper page
  48. Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016;15(3):428–35. https://doi.org/10.1111/acel.12445. · DOI · Paper page
  49. McHugh D, Gil J. Senescence and aging: causes, consequences, and therapeutic avenues. J Cell Biol. 2018;217(1):65–77. https://doi.org/10.1083/jcb.201708092. · DOI · Paper page
  50. Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, et al. Cellular senescence promotes adverse effects of chemotherapy and Cancer relapse. Cancer Discov. 2017;7(2):165–76. https://doi.org/10.1158/2159-8290.Cd-16-0241. · DOI · Paper page
  51. Ritschka B, Storer M, Mas A, Heinzmann F, Ortells MC, Morton JP, et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev. 2017;31(2):172–83. https://doi.org/10.1101/gad.290635.116. · DOI · Paper page
  52. Yang M, Teng S, Ma C, Yu Y, Wang P, Yi C. Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling. Cytotechnology. 2018;70(5):1301–13. https://doi.org/10.1007/s10616-018-0220-x. · DOI
  53. Park SY, Jeong AJ, Kim GY, Jo A, Lee JE, Leem SH, et al. Lactoferrin protects human Mesenchymal stem cells from oxidative stress-induced senescence and apoptosis. J Microbiol Biotechnol. 2017;27(10):1877–84. https://doi.org/10.4014/jmb.1707.07040. · DOI
  54. Lin TM, Tsai JL, Lin SD, Lai CS, Chang CC. Accelerated growth and prolonged lifespan of adipose tissue-derived human mesenchymal stem cells in a medium using reduced calcium and antioxidants. Stem Cells Dev. 2005;14(1):92–102. https://doi.org/10.1089/scd.2005.14.92. · DOI
  55. Lee JH, Jung HK, Han YS, Yoon YM, Yun CW, Sun HY, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14(4):3777–84. https://doi.org/10.3892/mmr.2016.5706. · DOI
  56. Kornienko JS, Smirnova IS, Pugovkina NA, Ivanova JS, Shilina MA, Grinchuk TM, et al. High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells. Sci Rep. 2019;9(1):1296. https://doi.org/10.1038/s41598-018-37972-y. · DOI · Paper page
  57. Dai Z, Jin Y, Zheng J, Liu K, Zhao J, Zhang S, et al. MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis. Biomed Pharmacother. 2019;109:1112–9. https://doi.org/10.1016/j.biopha.2018.10.166. · DOI
  58. Li H, Fan J, Fan L, Li T, Yang Y, Xu H, et al. MiRNA-10b reciprocally stimulates osteogenesis and inhibits adipogenesis partly through the TGF-β/SMAD2 signaling pathway. Aging Dis. 2018;9(6):1058–73. https://doi.org/10.14336/ad.2018.0214. · DOI
  59. Fan J, An X, Yang Y, Xu H, Fan L, Deng L, et al. MiR-1292 targets FZD4 to regulate senescence and osteogenic differentiation of stem cells in TE/SJ/mesenchymal tissue system via the Wnt/β-catenin pathway. Aging Dis. 2018;9(6):1103–21. https://doi.org/10.14336/ad.2018.1110. · DOI
  60. Galkin F, Zhang B, Dmitriev SE, Gladyshev VN. Reversibility of irreversible aging. Ageing Res Rev. 2019;49:104–14. https://doi.org/10.1016/j.arr.2018.11.008. · DOI
  61. Hynes K, Menicanin D, Han J, Marino V, Mrozik K, Gronthos S, et al. Mesenchymal stem cells from iPS cells facilitate periodontal regeneration. J Dent Res. 2013;92(9):833–9. https://doi.org/10.1177/0022034513498258. · DOI
  62. Spitzhorn LS, Megges M, Wruck W, Rahman MS, Otte J, Degistirici Ö, et al. Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. Stem Cell Res Ther. 2019;10(1):100. https://doi.org/10.1186/s13287-019-1209-x. · DOI
  63. Fernandez-Rebollo E, Franzen J, Goetzke R, Hollmann J, Ostrowska A, Oliverio M, et al. Senescence-associated Metabolomic phenotype in primary and iPSC-derived Mesenchymal stromal cells. Stem Cell Reports. 2020;14(2):201–9. https://doi.org/10.1016/j.stemcr.2019.12.012. · DOI
  64. Kornicka K, Marycz K, Marędziak M, Tomaszewski KA, Nicpoń J. The effects of the DNA methyltranfserases inhibitor 5-Azacitidine on ageing, oxidative stress and DNA methylation of adipose derived stem cells. J Cell Mol Med. 2017;21(2):387–401. https://doi.org/10.1111/jcmm.12972. · DOI
  65. Assis RIF, Wiench M, Silvério KG, da Silva RA, Feltran GDS, Sallum EA, et al. RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation. PLoS One. 2018;13(12):e0207873. https://doi.org/10.1371/journal.pone.0207873. · DOI
  66. Gao B, Lin X, Jing H, Fan J, Ji C, Jie Q, et al. Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice. Aging Cell. 2018;17(3):e12741. https://doi.org/10.1111/acel.12741. · DOI
  67. Ito T, Teo YV, Evans SA, Neretti N, Sedivy JM. Regulation of cellular senescence by Polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways. Cell Rep. 2018;22(13):3480–92. https://doi.org/10.1016/j.celrep.2018.03.002. · DOI · Paper page

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Metadata

Authors
Liu, Y., & Chen, Q.
ORCID
Chen, Qian
Venue
Current Molecular Biology Reports
Publisher
Springer Science and Business Media LLC
Published
2020-10-28
Volume
6
Issue
4
Pages
173-182
ISSN
2198-6428
DOI
10.1007/s40610-020-00141-0
PMC
PMC8011589
Cited by
41
References
11
Language
en
Licence
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R61AR076807-01)
  • National Institute of General Medical Sciences (P30 GM122732)

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