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Rejuvenation of Bone Marrow Mesenchymal Stem Cells: Mechanisms and Their Application in Senile Osteoporosis Treatment

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A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease

Summers, B. S., Broome, S. T., Pang, T. W. R., Mundell, H. D., Belic, N. K., Tom, N., Ng, M. L., Yap, M. L., Sen, M. K., Sedaghat, S., et al. (2024) · International Journal of Tryptophan Research · doi:10.1177/11786469241248287 · Cited by 20 · see citing works

How to enhance MSCs therapeutic properties? An insight on potentiation methods

García-Guerrero, C., Fuentes, P., Araya, M. J., Djouad, F., Luz‐Crawford, P., Vega-Letter, A. M., & Altamirano, C. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03935-6 · Cited by 20 · see citing works

Melatonin finely tunes proliferation and senescence in hematopoietic stem cells

Cruciani, S., Garroni, G., Pala, R., Barcessat, A. R. P., Facchin, F., Ventura, C., Fozza, C., & Maioli, M. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151251 · Cited by 19 · see citing works

Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence

Hu, C., Feng, Y., Huang, G., Cui, K., Fan, M., Xiang, W., Shi, Y., Ye, D., Ye, H., Bai, X., et al. (2023) · Journal of Pineal Research · doi:10.1111/jpi.12916 · Cited by 18 · see citing works

Genome-wide DNA methylation of Munro’s microabscess reveals the epigenetic regulation in the pathogenesis of psoriasis

Xu, X., Zhang, Y., Pan, Z., Zhang, X., Liu, X., Tang, L., Zhang, X., Zhou, F., & Cheng, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1057839 · Cited by 17 · see citing works

A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies

Zhao, H., Zhao, H., & Ji, S. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10732-4 · Cited by 17 · see citing works

Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy

Zhang, L., Ding, F., Wu, X., Wang, R., Wan, Y., Hu, J., Zhang, X., & Wu, Q. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114719 · Cited by 18 · see citing works

Enhancing the therapeutic efficacy of mesenchymal stem cell transplantation in diabetes: Amelioration of mitochondrial dysfunction-induced senescence

Lee, H. J., Chae, C. W., & Han, H. J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115759 · Cited by 16 · see citing works

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Sun, J., Zhou, H., Chen, Z., Zhang, H., Cao, Y., Yao, X., Chen, X., Liu, B., Gao, Z., Shen, Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04694-3 · Cited by 16 · see citing works

Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells

Nir, D., Ribarski-Chorev, I., Shimoni, C., Strauss, C., Frank, J., & Schlesinger, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105750 · Cited by 16 · see citing works

Protective effect of MitoQ on oxidative stress-mediated senescence of canine bone marrow mesenchymal stem cells via activation of the Nrf2/ARE pathway

Zhong, L., Deng, J., Gu, C., Shen, L., Ren, Z., Ma, X., Yan, Q., Deng, J., Zuo, Z., Wang, Y., et al. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-021-00605-2 · Cited by 15 · see citing works

Pectin-coated Malvidin-3-O-galactoside attenuates silica-induced pulmonary fibrosis by promoting mitochondrial autophagy and inhibiting cell apoptosis

Yang, Y., Ma, C., Wang, Y., Tian, J., Li, B., & Zhao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156566 · Cited by 14 · see citing works

Potential Preventive Strategies for Amyotrophic Lateral Sclerosis

Kuraszkiewicz, B., Goszczyńska, H., Podsiadły-Marczykowska, T., Piotrkiewicz, M., Andersen, P. M., Gromicho, M., Großkreutz, J., Kuźma‐Kozakiewicz, M., Petri, S., Stubendorff, B., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00428 · Cited by 15 · see citing works

Human Fibroblast Growth Factor-Treated Adipose-Derived Stem Cells Facilitate Wound Healing and Revascularization in Rats with Streptozotocin-Induced Diabetes Mellitus

Chang, S., Lee, J. H., Oh, S. C., Lee, M. Y., & Lim, N. K. (2023) · Cells · doi:10.3390/cells12081146 · Cited by 13 · see citing works

Decreased miR-17-92 cluster correlates with senescence features, disrupted oxidative homeostasis, and impaired therapeutic efficacy of mesenchymal stem cells

Cen, Y., Qi, J., Chen, L., Xia, C., Zheng, M., Liu, Y., & Lou, G. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00515.2022 · Cited by 11 · see citing works

Melatonin-coated nanofiber cell sheets promote periodontal regeneration through ROS scavenging and preservation of stemness

Tang, W., Huo, F., Ju, R., Gao, X., He, M., Long, J., Zhang, J., Zhang, S., & Tian, W. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154626 · Cited by 10 · see citing works

Mitophagy involved the biological processes of hormones

Ma, Y., Zheng, Y., Zhou, Y., Weng, N., & Zhu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115468 · Cited by 9 · see citing works

The mitochondria chronicles of melatonin and ATP: Guardians of phase separation

Loh, D., & Reiter, R. J. (2024) · Mitochondrial Communications · doi:10.1016/j.mitoco.2024.07.002 · Cited by 9 · see citing works

Mitochondrial homeostasis in stem cell senescence

Peng, B., & Zhang, H. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610006 · Cited by 8 · see citing works

VEGFR3 MITIGATES HYPERTENSIVE NEPHROPATHY BY ENHANCING MITOPHAGY VIA REGULATING CROTONYLATION OF HSPA1L

Wu, Q., Fu, J., Zhu, B., Meng, W., Ma, J., Lv, Y., Zhao, W., Wang, F., Liu, J., Wang, Y., et al. (2025) · Journal of Hypertension · doi:10.1097/01.hjh.0001197376.28877.a0 · Cited by 8 · see citing works

Circadian and non-circadian melatonin: influences on glucose metabolism in cancer cells

Reiter, R. J. (2020) · Journal of Current Science and Technology · doi:10.14456/jcst.2020.9 · Cited by 7 · see citing works

Renal aging and mitochondrial quality control

Guo, X., Wang, J., Wu, Y., Zhu, X., & Xu, L. (2024) · Biogerontology · doi:10.1007/s10522-023-10091-6 · Cited by 7 · see citing works

Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression

Go, G., Yoon, Y. M., Yoon, S., Lee, G., Lim, J. H., Han, S.-Y., & Lee, S. H. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.058 · Cited by 7 · see citing works

Cellular Senescence in Craniofacial Tissue Regeneration: Inducers, Biomarkers, and Interventions

Tang, W., Huo, F., Long, J., Zhang, S., & Tian, W. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0136 · Cited by 6 · see citing works

Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing

Mousavi, S. M., Etemad, L., Yari, D., Hashemi, M., & Salmasi, Z. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575299255240422055203 · Cited by 5 · see citing works

Mechanistic insights into epigenetic contributions to psoriasis pathogenesis and their clinical implications

Wang, Y., Jiang, Y., Lu, J., & Shi, Y. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102590 · Cited by 5 · see citing works

Melatonin as mitochondria-targeted drug

Süzen, S., & Saso, L. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.006 · Cited by 5 · see citing works

The Potential of Melatonin to Treat Atherosclerosis by Targeting Mitochondria

Sun, X., Chen, L., & Gui, Q. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230116102054 · Cited by 4 · see citing works

Imbalance of early-life vitamin D intake targets ROS-mediated crosstalk between mitochondrial dysfunction and differentiation potential of MSCs associated the later obesity

Li, P., Wang, Y., Liang, Y., Jiang, X., Tang, T., Fan, X., Wang, R., Yang, M., Liu, Y., Qi, K., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03860-8 · Cited by 4 · see citing works

Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells

Sheng, L., Suo, Y., Hong, S., Wu, X., Li, Y., Chen, B., Qin, J., Wu, L., Diwu, J., & Zhou, X. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141555 · Cited by 3 · see citing works

Senescence recovering by dual drug-encapsulated liposomal nanoparticles for large-scale human cell expansion

Ashiba, K., Mino, K., Okido, Y., Sato, K., & Kawakami, H. (2022) · Journal of Artificial Organs · doi:10.1007/s10047-022-01356-x · Cited by 3 · see citing works

Senolytic Phytocompounds in Redox Signaling

Thirumurugan, K. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-84965-8_12 · Cited by 3 · see citing works

SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies

Liu, H., Ouyang, Y., & Ge, H. (2025) · Human Cell · doi:10.1007/s13577-025-01285-w · Cited by 2 · see citing works

Aging and “rejuvenation” of resident stem cells — a new way to active longevity?

Baklaushev, V. P., Samoilova, E. M., Анатольевич, К. В., & Yusubalieva, G. M. (2022) · Journal of clinical practice · doi:10.17816/clinpract104999 · Cited by 2 · see citing works

Melatonin pretreatment can improve the therapeutic effect of adipose-derived stem cells on CCl4-induced liver fibrosis

Zhang, Z., Sun, Y., Wang, H., Yang, Y., Dong, R., Xu, Y., Zhang, M., Lv, Q., Chen, X., & Liu, Y. (2023) · Toxin Reviews · doi:10.1080/15569543.2023.2191263 · Cited by 2 · see citing works

Senomorphic, senolytic, and rejuvenation therapies

Zhu, X. Y., & Lerman, L. O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00025-1 · Cited by 2 · see citing works

Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammationPreprint

Sagar, S., Faizan, M. I., Chaudhary, N., Gheware, A., Sharma, K., Azmi, I., Singh, V. P., Kharya, G., Mabalirajan, U., Agrawal, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.27.470183 · Cited by 2 · see citing works

Mesenchymal stem cells with p38 mitogen-activated protein kinase interference ameliorate mouse ischemic stroke

Bai, Y., Wang, L., Xu, R., & Cui, Y. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231220663 · Cited by 1 · see citing works

Bidirectional effect of intestinal microbiome and host in circadian rhythm disruption: Environmental factors and breast cancer development

Engin, D., Engin, A. B., & Engin, A. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.104939 · Cited by 1 · see citing works

Targeting Mitochondria as a Strategy to Inhibit Cellular Senescence

Tan, I. L., & Velarde, M. C. (2021) · Current Molecular Biology Reports · doi:10.1007/s40610-021-00143-6 · Cited by 1 · see citing works

Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?

Roato, I., Visca, M., & Mussano, F. D. (2024) · Biomedicines · doi:10.3390/biomedicines12122811 · Cited by 1 · see citing works

Decreased miR-17-92 Cluster Correlates With the Senescent Features and Disrupted Oxidative Homeostasis, and the Impaired Therapeutic Efficacy of Adipose Tissue-derived Mesenchymal Stem CellsPreprint

Cen, Y., Qi, J., Chen, L., Liu, Y., & Lou, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1333637/v1

Melatonin pretreatment can improve the therapeutic effect of Adipose-derived Stem Cells on CCl4-induced liver fibrosisPreprint

Zhang, Z., Sun, Y., Wang, H., Yang, Y., Dong, R., Xu, Y., Zhang, M., Lv, Q., Chen, X., & Liu, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-868703/v1

Fundamental Mechanisms of Cytoprotection Induced by Stem Cells: Focus on Immune Response and Cellular Metabolism

Semedo, P., Câmara, N. O. S., & Novikoff, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00092-5

Effect of melatonin on oxidative stress of differentiated Dopaminergic cells

Ibrahim, H. A. M., Hussein, A. M., Gabr, M., Abdel-Aziz, A. F., & El-Saeed, R. A. (2023) · Egyptian Pharmaceutical Journal · doi:10.4103/epj.epj_22_23

Revitalizing mesenchymal stem cells: Mechanisms of aging and role of herbal preconditioning in combating senescence

Elmi, F., Soltanmohammadi, F., Keshavarz, P., & Alizadeh, E. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107311

Comprehensive Analysis and Experimental Validation of Immune-Related Biomarkers and Immune Microenvironment in Diabetic Nephropathy

Zhou, W., Zeng, Z., Li, X., & Yang, M. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s541886

Additional file 1 of New insights into mitophagy and stem cells

Lin, Q., Chen, J., Gu, L., Dan, X., Zhang, C., & Yang, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15153841

Additional file 2 of Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Sun, J., Zhou, H., Chen, Z., Zhang, H., Cao, Y., Yao, X., Chen, X., Liu, B., Gao, Z., Shen, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24630475

Additional file 1 of Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Sun, J., Zhou, H., Chen, Z., Zhang, H., Cao, Y., Yao, X., Chen, X., Liu, B., Gao, Z., Shen, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24630340

Mechanisms and Drug-Augmenting Strategies of Mesenchymal Stem Cells for Preserving β-Cell in Type 2 Diabetes

Wang, K., Li, J., Han, C., & Li, J. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s586404

Cadmium induces renal injury via a BMAL1-dependent inflammatory and senescence cascade: Attenuation by Lycium barbarum polysaccharide and melatonin

Yu, G., Fu, X., Zhou, D., Ma, Y., Zou, H., Song, R., Bian, J., Liu, Z., & Tong, X. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120563

Mesenchymal stem cell senescence as a potency brake: causes, consequences, and cures

Zhou, S., Xie, Y., Guo, Y., Zhang, Y., & Liu, Y. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1929624

Melatonin Enhances Mitophagy by Upregulating Expression of Heat Shock 70 kDa Protein 1L in Human Mesenchymal Stem Cells under Oxidative Stress

Yoon, Y. M., Kim, H. J., Lee, J. H., & Lee, S. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184545 · Cited by 33 · see citing works

Melatonin finely tunes proliferation and senescence in hematopoietic stem cells

Cruciani, S., Garroni, G., Pala, R., Barcessat, A. R. P., Facchin, F., Ventura, C., Fozza, C., & Maioli, M. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151251 · Cited by 19 · see citing works

Melatonin reverses H ₂ O ₂ ‐induced premature senescence in mesenchymal stem cells via the <scp>SIRT</scp> 1‐dependent pathway

Zhou, L., Chen, X., Liu, T., Gong, Y., Chen, S., Pan, G., Cui, W., Luo, Z., Pei, M., Yang, H., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12250 · Cited by 158 · see citing works

Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3

Zhang, Z., Bao, Y., Wei, P., Yan, X., Qiu, Q., & Qiu, L. (2023) · Oral Diseases · doi:10.1111/odi.14649 · Cited by 9 · see citing works

Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Wu, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020697 · Cited by 29 · see citing works