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Cited by 152Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersLGBTQ Health, Identity, and Policy

Self-Esteem and Social Adjustment in Young Women with Turner Syndrome—Influence of Pubertal Management and Sexuality: Population-Based Cohort Study

Carel, Jean-Claude, Elie, Caroline, Ecosse, Emmanuel, Tauber, Maïthé, Léger, Juliane, Cabrol, Sylvie, Nicolino, Marc, Brauner, Raja +2 more·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-2652
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Abstract

CONTEXT: Pediatric management of patients with Turner syndrome focuses on height, frequently resulting in a delay of pubertal induction. The influence of pubertal management on psychosocial adjustment and sex life has not been evaluated in Turner syndrome patients. OBJECTIVE: The objective of the study was to identify the determinants of self-esteem, social adjustment, and initiation of sex life in patients with Turner syndrome, particularly those related to pubertal management. DESIGN: This was a prospective evaluation, the StaTur study. SETTING: The study was conducted with a population-based registry of GH-treated patients. PARTICIPANTS: Participants included 566 young adult women with Turner syndrome, aged 22.6 +/- 2.6 yr (range, 18.3-31.2). MAIN OUTCOME MEASURES: Measures used in the study were Coopersmith's Self-Esteem Inventory, Social Adjustment Scale Self-Report, questions on sexual experience, and extensive data on pediatric management. RESULTS: Low self-esteem was associated with otological involvement and limited sexual experience. Low social adjustment was associated with lower paternal socioeconomic class and an absence of sexual experience. Late age at first kiss or date was associated with cardiac involvement and a lack of spontaneous pubertal development. Age at first sexual intercourse was related to age at puberty and paternal socioeconomic class. Delayed induction of puberty had a long-lasting effect on sex life. Height and height gain due to GH treatment had no effect on outcomes. CONCLUSIONS: Puberty should be induced at a physiologically appropriate age in patients with Turner syndrome to optimize self-esteem, social adjustment, and initiation of the patient's sex life. Therapeutic interventions altering normal pubertal development in other groups of patients should be reconsidered in light of these findings.

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Crossref · 10.1210/jc.2005-2652

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  • Despite having normal sex drive/libido, individuals with TS are less likely to be married or in relationships compared to women of the same age.

    “Despite having normal sex drive/libido, individuals with TS are less likely to be married or in relationships as compared to women of the same age.371,372,569,570”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [371]

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Authors
Carel, J.-C., Elie, C., Ecosse, E., Tauber, M., Léger, J., Cabrol, S., Nicolino, M., Brauner, R., Chaussain, J.-L., & Coste, J.
Affiliations
  • Inserm (FR)
  • Hôpital Cochin (FR)
  • Department of Biostatistics (C.E., E.E., J.C.), Groupe Hospitalier Cochin-Saint Vincent de Paul and Université Paris V, 75014 Paris, France
  • Hôpital des Enfants (FR)
  • Department of Pediatric Endocrinology (J.L.), Hôpital Robert Debré, 75935 Paris, France
  • Hôpital Armand-Trousseau (FR)
  • Hospices Civils de Lyon (FR)
  • Bicêtre Hospital (FR)
Corresponding author
Carel, Jean-Claude
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-08-01
Volume
91
Issue
8
Pages
2972-2979
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-2652
OpenAlex
W2043794909
Cited by
152
References
48
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 16 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 8
FWCI
5.30
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
Keywords
Turner syndrome, self-esteem, social adaptation, puberty induction, puberty, sexual initiation, growth hormone therapy, young women, cardiac involvement, psychosocial outcomes
MeSH terms
Adolescent, Adult, Age Factors, Analysis of Variance, Body Height, Coitus, Female, Humans, Menarche, Puberty, Surveys and Questionnaires, Self Concept, Sexual Behavior, Social Adjustment, Socioeconomic Factors, Turner Syndrome, Body Mass Index, Sexuality

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