Effect of acute standing and prolonged upright activity on left ventricular hemodynamics, systolic and diastolic intervals, and QT-QS2 relationship
Abstract
It is generally accepted that upright posture decreases preload and afterload, which could alter left ventricular (LV) performance. It is not known if changes occurring with acute standing persist after prolonged ambulatory activity (amb-act). In seven normal subjects echocardiographic end-diastolic and end-systolic diameters, percent shortening of the internal diameter (% delta D) and end-systolic wall stress (ES-WS), radionuclide diastolic volume and ejection fraction, preejection period over left ventricular ejection time (PEP/LVET), and diastolic time and QT-QS2 were measured supine, within 1 to 2 minutes after standing and after prolonged (60 minutes) amb-act. In addition, serial measurements were performed in PEP/LVET for 105 minutes at 15-minute intervals. With acute standing, end-diastolic diameter, diastolic volume, and ES-WS decreased (p less than 0.01); heart rate and PEP/LVET increased (p less than 0.01); while % delta D and ejection fraction remained unchanged. There was an inverse correlation between change in PEP/LVET and diastolic diameter (r = -0.59), but no correlation between PEP/LVET and ES-WS. The diastolic time per beat and per minute decreased (375 +/- 115 msec from 519 +/- 176 msec [p less than 0.01] and 31.3 +/- 4.2 sec/min from 33.7 +/- 4.5 sec/min [p less than 0.01]). The QT-QS2 increased when compared to supine (-7 +/- 7.6 msec from -22 +/- 7.7 msec [p less than 0.005]), but the QT-QS2 relationship remained normal (QT less than or equal to QS2). All the dynamic changes that occurred with acute standing tended to persist during prolonged amb-act.
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The increase in PEP and decrease in LVET with posture change is well documented in prior literature and attributed to changes in preload, contractility, and afterload.
“The increase in PEP and the decrease in LVET is well documented in prior literature [26,47] and is attributed to changes in preload, contractility, and afterload.”
From A Chest‐Conformable, Wireless Electro‐Mechanical E‐Tattoo for Measuring Multiple Cardiac Time Intervals (2023) · cites this paper as [47]
Cites
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works
Systolic Time Intervals in Heart Failure in Man
WEISSLER, A. M., HARRIS, W. S., & SCHOENFELD, C. D. (1968) · Circulation · doi:10.1161/01.cir.37.2.149 · Cited by 1,217 · see citing works
Reichek, N., Wilson, J., Sutton, M. S. J., Plappert, T. A., Goldberg, S., & Hirshfeld, J. W. (1982) · Circulation · doi:10.1161/01.cir.65.1.99 · Cited by 653 · see citing works
A critical review of the systolic time intervals.
Lewis, R. P., Rittogers, S. E., Froester, W. F., & Boudoulas, H. (1977) · Circulation · doi:10.1161/01.cir.56.2.146 · Cited by 624 · see citing works
Self-citationThe ventricular pressure-volume diagram revisited.
SAGAWA, K. (1978) · Circulation Research · doi:10.1161/01.res.43.5.677 · Cited by 484 · see citing works
Bevegård, S., Holmgren, A., & Jönsson, B. (1960) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1960.tb01953.x · Cited by 446 · see citing works
McMICHAEL, J., & Sharpey‐Schafer, E. P. (1944) · Heart · doi:10.1136/hrt.6.1.33 · Cited by 277 · see citing works
Stead, E. A., Warren, J. V., Merrill, A. J., & Brannon, E. S. (1945) · Journal of Clinical Investigation · doi:10.1172/jci101609 · Cited by 255 · see citing works
Reflexes From Stretch Receptors in Blood Vessels, Heart and Lungs
Aviado, D. M., & Schmidt, C. F. (1955) · Physiological Reviews · doi:10.1152/physrev.1955.35.2.247 · Cited by 228 · see citing works
Changes in diastolic time with various pharmacologic agents: implication for myocardial perfusion.
Boudoulas, H., Rittgers, S. E., Lewis, R. P., Leier, C. V., & Weissler, A. M. (1979) · Circulation · doi:10.1161/01.cir.60.1.164 · Cited by 205 · see citing works
Self-citationMarsh, J. D., Green, L. H., Wynne, J., Cohn, P. F., & Grossman, W. (1979) · The American Journal of Cardiology · doi:10.1016/0002-9149(79)90446-6 · Cited by 201 · see citing works
Effect of arterial impedance changes on the end-systolic pressure-volume relation.
Maughan, W. L., Sunagawa, K., Burkhoff, D., & SAGAWA, K. (1984) · Circulation Research · doi:10.1161/01.res.54.5.595 · Cited by 178 · see citing works
Cardiovascular dynamics during orthostasis and the influence of intravascular instrumentation
STEVENS, P. M. (1966) · The American Journal of Cardiology · doi:10.1016/0002-9149(66)90354-7 · Cited by 170 · see citing works
The uses and limitations of end-systolic indexes of left ventricular function.
Carabello, B. A., & Spann, J. F. (1984) · Circulation · doi:10.1161/01.cir.69.5.1058 · Cited by 152 · see citing works
Linear Relationship Between Electrical Systole, Mechanical Systole, and Heart Rate
Boudoulas, H. K., Geleris, P., Lewis, R. P., & Rittgers, S. E. (1981) · CHEST Journal · doi:10.1378/chest.80.5.613 · Cited by 105 · see citing works
Self-citationShaver, J. A., Kroetz, F. W., Leonard, J. J., & Paley, H. W. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105711 · Cited by 105 · see citing works
Alterations in preload and ejection phase indices of left ventricular performance,.
Rankin, L. S., Moos, S., & Grossman, W. (1975) · Circulation · doi:10.1161/01.cir.51.5.910 · Cited by 95 · see citing works
Plasma catechol amine and electroencephalographic responses to acute postural change
Hickler, R. B., Wells, R. E., Tyler, H. R., & Hamlin, J. T. (1959) · The American Journal of Medicine · doi:10.1016/0002-9343(59)90249-9 · Cited by 88 · see citing works
Normal left ventricular function.
Parker, J. O., & Case, R. (1979) · Circulation · doi:10.1161/01.cir.60.1.4 · Cited by 88 · see citing works
Cardiopulmonary readjustments in passive tilt
Matalon, S. V., & Farhi, L. E. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.47.3.503 · Cited by 74 · see citing works
The relation between heart volume and stroke volume in recumbent and erect positions1
Nylin, G. (1934) · Skandinavisches Archiv Für Physiologie · doi:10.1111/j.1748-1716.1934.tb01099.x · Cited by 70 · see citing works
The QT > QS2 syndrome: A new mortality risk indicator in coronary artery disease
Boudoulas, H. K., Sohn, Y. H., O’Neill, W. W., Brown, R., & Weissler, A. M. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90454-4 · Cited by 67 · see citing works
Self-citationBoudoulas, H. K., Geleris, P., Lewis, R. P., & Leier, C. V. (1981) · Circulation · doi:10.1161/01.cir.64.1.28 · Cited by 65 · see citing works
Self-citationAn ambulatory ventricular function monitor: Validation and preliminary clinical results
Wilson, R. A., Sullivan, P. J., Moore, R. H., Zielonka, J. S., Alpert, N. M., Boucher, C. A., McKusick, K. A., & Strausś, H. W. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90034-6 · Cited by 65 · see citing works
Orthostatic changes of the pulmonary and peripheral circulation in man a preliminary report
Eliasch, H., Werkö, L., Berglund, E., Ekberg, E., Ekdahl, B., Hanson, M., & LAGERLÖF, H. O. (1951) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365515109060578 · Cited by 62 · see citing works
Redwood, D. R., Henry, W. L., & Epstein, S. E. (1974) · Circulation · doi:10.1161/01.cir.50.5.901 · Cited by 60 · see citing works
Noninvasive Cardiovascular Diagnosis.
(1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-90-3-485_1 · Cited by 53 · see citing works
Influence of Posture on Cardiac Output and Minute Ventilation During Exercise
McGregor, M., Adam, W. R., & SEKELJ, P. (1961) · Circulation Research · doi:10.1161/01.res.9.5.1089 · Cited by 45 · see citing works
Rapaport, E., Wong, M., Escobar, E., & Martinez, G. (1966) · American Heart Journal · doi:10.1016/0002-8703(66)90177-3 · Cited by 40 · see citing works
QTQS2 ratio as an index of autonomic tone changes
Caprio, L. D., Ferro, G., Cuomo, S., Volpeau, M., Artiaco, D., LUCA, N. D., & Ricciardelli, B. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90411-9 · Cited by 35 · see citing works
Carel, R. S., Silverberg, D. S., Shoenfeld, Y., Eldar, M., Snir, C., & Mor, G. (1983) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198303000-00001 · Cited by 24 · see citing works
Howard, P. F., & Leathart, G. L. (1951) · PubMed · Cited by 19 · see citing works
Increased left ventricular emptying at maximal exercise after reduction in afterload.
Andersen, K., & Vik‐Mo, H. (1984) · Circulation · doi:10.1161/01.cir.69.3.492 · Cited by 19 · see citing works
The effect of upright tilt on the volume of the failing human left ventricle
Stefadouros, M. A., Shahawy, M. E., Stefadouros, F., & Witham, A. C. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90463-9 · Cited by 14 · see citing works
Rolfe, S. J., Rasor, T., Shaffer, P. A., Sanitate, P. A., & Bashore, T. M. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90631-3 · Cited by 12 · see citing works
Self-citationCentral and Peripheral Catecholamine Mechanisms in Circulatory Control
Reid, J. L., & Dollery, C. T. (2008) · Cardiology · doi:10.1159/000169803 · Cited by 11 · see citing works
Effects of orthostatic postural changes on myocardial oxygen demands
Langou, R. A., Wolfson, S., Olson, E. G., & Cohen, L. S. (1977) · The American Journal of Cardiology · doi:10.1016/s0002-9149(77)80099-4 · Cited by 10 · see citing works
The effect of tilting on the right atrial pressure of patients with heart failure
Ryan, J. M., Oser, B. M., & Huston, J. R. (1958) · American Heart Journal · doi:10.1016/0002-8703(58)90003-6 · Cited by 5 · see citing works
Left Ventricular Pressure Responses in Post‐Angiographic Angina
Boudoulas, H. K., & Leighton, R. F. (1975) · Catheterization and Cardiovascular Diagnosis · doi:10.1002/ccd.1810010408 · Cited by 4 · see citing works
Self-citationKossmann, C. E. (1961) · Circulation · doi:10.1161/01.cir.24.2.326 · Cited by 3 · see citing works
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Cacioppo, J. T., Uchino, B. N., & Berntson, G. G. (1994) · Psychophysiology · doi:10.1111/j.1469-8986.1994.tb02449.x · Cited by 223 · see citing works
Di Rienzo, M., Vaini, E., Castiglioni, P., Merati, G., Meriggi, P., Parati, G., Faini, A., & Rizzo, F. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.04.005 · Cited by 163 · see citing works
Effects of variation in posture and respiration on RSA and pre‐ejection period
Houtveen, J. H., Groot, P. F. C., & de Geus, E. J. C. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00363.x · Cited by 88 · see citing works
Bhattacharya, S., Nikbakht, M., Alden, A., Tan, P., Wang, J., Alhalimi, T. A., Kim, S., Wang, P., Tanaka, H., Tandon, A., et al. (2023) · Advanced Electronic Materials · doi:10.1002/aelm.202201284 · Cited by 42 · see citing works
Assantachai, P., Chatthanawaree, W., Thamlikitkul, V., Praditsuwan, R., & Pisalsarakij, D. (2002) · PubMed · Cited by 24 · see citing works
Franklin, J. O., Alpert, M., Twardowski, Z. J., Khanna, R., Nolph, K. D., Morgan, R. J., & Kelly, D. L. (1988) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(88)80222-1 · Cited by 22 · see citing works
Cardiac size and motion during water immersion: Implications for volume homeostasis
Kinney, E. L., Cortada, X., & Ventura, R. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90276-6 · Cited by 17 · see citing works
Alpert, M., Franklin, J. O., Twardowski, Z. J., Khanna, R., Nolph, K. D., & Morgan, R. J. (1990) · Springer eBooks · doi:10.1007/978-1-4615-9555-7_65 · Cited by 2 · see citing works
CIRCULATORY RESPONSES TO SUDDEN STRENUOUS EXERCISE
GWON, O., Fukuoka, Y., Sone, R., Nabekura, Y., & IKEGAMI, H. (1991) · 体力科學 · doi:10.7600/jspfsm1949.40.483
- Authors
- Boudoulas, H., Barrington, W., Olson, S. M., Bashore, T. M., & Wooley, C. F.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Boudoulas, Harisios
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 1985-09
- Volume
- 110
- Issue
- 3
- Pages
- 623-630
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2005668582
- Cited by
- 9
- References
- 41
- Citations by year
- 2023: 1 · 2013: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- upright posture, standing, left ventricular hemodynamics, diastolic time, pre-ejection period, end-systolic wall stress, end-diastolic diameter, ejection fraction, preload and afterload, diastolic function
- MeSH terms
- Adult, Blood Pressure, Diastole, Echocardiography, Electrocardiography, Female, Heart, Heart Rate, Heart Ventricles, Humans, Male, Posture, Radionuclide Imaging, Systole, Time Factors, Ventricular Function
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