Circulating proinsulin in patients with maturity onset diabetes
Abstract
The contribution of proinsulin to the total serum immunoreactive insulin (IRI) was measured in 59 patients with maturity onset diabetes (23 being treated with diet alone and 36 with oral sulfonylurea agents) and compared to that in 44 control subjects. The percentage of proinsulin was increased in 11 patients and correlated with plasma glucose, but not with IRI. There was no difference between the drug-treated group and diet-treated group, or between patients taking different sulfonylurea agents. Sequential studies in one patient showed normalization of the proportion of proinsulin following lowering of the plasma glucose level. It is probably that the increased circulating proportion of proinsulin in hyperglycemic diabetic patients is secondary to beta cell exhaustion with release of less mature granules.
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In established Type 2 diabetes, there is inefficient proinsulin processing to insulin and a reduction in the release of islet amyloid polypeptide (IAPP)/amylin.
“inefficient proinsulin processing to insulin [77, 78, 79, 80, 81, 82, 83] and a reduction in the release of islet amyloid polypeptide (IAPP), known also as amylin [84, 85, 86, 87], have been observed in established Type 2 diabetes.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [77]
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- Authors
- Mako, M. E., Starr, J. I., & Rubenstein, A. H.
- Corresponding author
- Rubenstein, Arthur H.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1977-12
- Volume
- 63
- Issue
- 6
- Pages
- 865-869
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1975645985
- Cited by
- 99
- References
- 11
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- proinsulin, maturity-onset diabetes, type 2 diabetes, immunoreactive insulin, dietary therapy, plasma glucose, beta-cell exhaustion, insulin granules, hyperglycemia
- MeSH terms
- Adult, Aged, Antigens, Blood Glucose, Diabetes Mellitus, Female, Humans, Insulin, Islets of Langerhans, Male, Middle Aged, Proinsulin, Sulfonylurea Compounds
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