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Cited by 78Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

Effects of dexamethasone on glucose-induced insulin and proinsulin release in low and high insulin responders

Grill, V., Pigon, J., Hartling, S.G., Binder, C., Efendic, S.·1990·Metabolism
DOI 10.1016/0026-0495(90)90043-c
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Abstract

We compared the effects of dexamethasone-induced insulin resistance on B-cell secretory performance in 12 low insulin responders (LIR) and in eight high insulin responders (HIR). A hyperglycemic clamp (120 minutes) was performed before and after the subjects had ingested dexamethasone 3 mg x 2 for 2 1/2 days. Fasting levels of blood glucose increased from 4.60 +/- 0.13 to 5.74 +/- 0.23 mmol/L after dexamethasone in LIR and from 4.37 +/- 0.18 to 5.26 +/- 0.13 mmol/L in HIR. Dexamethasone treatment increased fasting levels of total immunoreactive insulin (IRI), C-peptide, and proinsulin, as well as the proinsulin to IRI ratio to a similar degree in LIR and HIR. The amount of glucose infused to uphold hyperglycemia during the clamp decreased by 54% after dexamethasone in LIR and by 46% in HIR. Mean level of stimulated IRI during the clamp increased after dexamethasone by 43% in LIR and by 53% in HIR. Mean level of stimulated C-peptide increased by 11% (not significant) in LIR and by 24% in HIR. Mean level of stimulated proinsulin increased by 86% in LIR and by 93% in HIR. The effects of dexamethasone on insulin secretion varied among individuals, since steroid treatment failed to affect IRI responses to glucose in two LIR and two HIR. The magnitude of dexamethasone effects on secretion was not correlated to pre-dexamethasone insulin sensitivity as assessed by a somatostatin-insulin-glucose infusion test (SIGIT) or by M/I (glucose infused/insulin level) ratios of the control clamp.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors
Grill, V., Pigon, J., Hartling, S. G., Binder, C., & Efendic, S.
Affiliations
Karolinska University Hospital (SE)
Corresponding author
Grill, V.
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1990-03
Volume
39
Issue
3
Pages
251-258
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(90)90043-c
OpenAlex
W1973883362
Cited by
78
References
35
Citations by year
2023: 2 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medicinska Forskningsrådet (0034, 04540)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
dexamethasone, insulin resistance, insulin secretion, proinsulin, C-peptide, hyperglycemic clamp, insulin sensitivity
MeSH terms
Insulin Secretion, Adult, Blood Glucose, C-Peptide, Dexamethasone, Drug Interactions, Female, Glucose, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Middle Aged, Proinsulin, Radioimmunoassay, Glucose Clamp Technique

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