Prevalence and risk factors of adenomyosis at hysterectomy
Abstract
BACKGROUND: The present study was performed to evaluate the prevalence and possible associated risk factors for adenomyosis. METHODS: Medical records were retrieved and histo-pathological material re-examined for 549 consecutive women undergoing hysterectomy in a two-year period from 1990-1991. RESULTS: The prevalence of adenomyosis in the study varied from 10.0-18.2%, depending on different diagnostic criteria. The presence of endometrial hyperplasia at the time of hysterectomy was the only variable significantly associated with adenomyosis (OR = 3.0; 95% CI: 1.2-8.3). No statistically significant association was found between adenomyosis and previous caesarean section, endometrial curettage or evacuation of the uterus. Furthermore, we did not see any significant association between adenomyosis and pain-related symptoms, indication for hysterectomy, age, parity or number of myometrial samples. CONCLUSIONS: Our study stresses the need for precise diagnostic criteria for adenomyosis, and furthermore indicates that endometrial hyperplasia and adenomyosis may have a common aetiology.
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The association between adenomyosis and multiparity has been challenged in a recent epidemiological study.
“However, this association between adenomyosis and multiparity has been challenged in a recent epidemiological study (36).”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [36]
Reported prevalence of adenomyosis varies from 10% to 57%.
“The reported prevalence of adenomyosis varies greatly among different studies, from as low as 10% to as high as 57% [15,16].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [16]
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- Authors
- Bergholt, T., Eriksen, L., Berendt, N., Jacobsen, M., & Hertz, J. B.
- Affiliations
- Gentofte Hospital (DK)
- ORCID
- Bergholt, T.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11
- Volume
- 16
- Issue
- 11
- Pages
- 2418-2421
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2151204568
- Cited by
- 227
- References
- 25
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 8 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 14 · 2018: 14 · 2017: 13 · 2016: 8 · 2015: 16 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- adenomyosis, prevalence, risk factors, hysterectomy, endometrial hyperplasia, diagnostic criteria, etiology, cesarean section, endometrial curettage, uterine evacuation, parity
- MeSH terms
- Adult, Cesarean Section, Curettage, Endometrial Hyperplasia, Endometriosis, Female, Humans, Hysterectomy, Middle Aged, Risk Factors
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