Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia
Abstract
Objective Our purpose was to investigate the plasma levels of three potent antioxidant nutrients in women with preeclampsia. Study design Fasting venous blood samples were collected from 30 women with preeclampsia and from 44 women with uncomplicated pregnancies. The criteria for recruitment included age 15 to 35 years, gestational age 28 to 42 weeks, singleton pregnancy, intact membranes, absence of labor contractions, and absence of any other medical complication concurrent with preeclampsia. Reduced ascorbic acid, alpha-tocopherol, and beta-carotene levels were assayed with high-pressure liquid chromatography. Results Plasma levels of reduced ascorbic acid were significantly decreased in patients with mild and severe preeclampsia (p Conclusion In patients with preeclampsia antioxidant nutrients may be utilized to a greater extent to counteract free radical-mediated cell disturbances, resulting in a reduction in antioxidant plasma levels. Water-soluble antioxidant nutrients may initially be consumed, followed by lipid-soluble antioxidants.
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In patients with preeclampsia, antioxidant nutrient levels and antioxidant response are lower, while lipid peroxidation is higher.
“In patients with preeclampsia, antioxidant nutrient levels as well as antioxidant response was lower while lipid peroxidation was higher (Takagi et al, 2004;Aydin et al, 2004 andMikhail et al, 1994).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Mikhail et al, 1994
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- Authors
- Mikhail, M. S., Anyaegbunam, A., Garfinkel, D., Palan, P. R., Basu, J., & Romney, S. L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Mikhail, Magdy S.
- ORCID
- Basu, Jayasri
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 171
- Issue
- 1
- Pages
- 150-157
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2063095299
- Cited by
- 229
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, antioxidant nutrients, reduced ascorbic acid, vitamin C, alpha-tocopherol, vitamin E, beta-carotene, free radicals, oxidative stress, pregnancy complications
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Carotenoids, Female, Humans, Pilot Projects, Pre-Eclampsia, Pregnancy, Vitamin E, Case-Control Studies, beta Carotene
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