Cited by 229Pregnancy and preeclampsia studiesAntioxidant Activity and Oxidative StressNeurological Complications and Syndromes

Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia

Mikhail, Magdy S., Anyaegbunam, Akolisa, Garfinkel, David, Palan, Prabhudas R., Basu, Jayasri, Romney, Seymour L.·1994·American Journal of Obstetrics and Gynecology

Abstract

Objective Our purpose was to investigate the plasma levels of three potent antioxidant nutrients in women with preeclampsia. Study design Fasting venous blood samples were collected from 30 women with preeclampsia and from 44 women with uncomplicated pregnancies. The criteria for recruitment included age 15 to 35 years, gestational age 28 to 42 weeks, singleton pregnancy, intact membranes, absence of labor contractions, and absence of any other medical complication concurrent with preeclampsia. Reduced ascorbic acid, alpha-tocopherol, and beta-carotene levels were assayed with high-pressure liquid chromatography. Results Plasma levels of reduced ascorbic acid were significantly decreased in patients with mild and severe preeclampsia (p Conclusion In patients with preeclampsia antioxidant nutrients may be utilized to a greater extent to counteract free radical-mediated cell disturbances, resulting in a reduction in antioxidant plasma levels. Water-soluble antioxidant nutrients may initially be consumed, followed by lipid-soluble antioxidants.

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Registry

Crossref · 10.1016/0002-9378(94)90462-6

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29 of 29 references verified0 citation errors · 0 not checkable

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  • In patients with preeclampsia, antioxidant nutrient levels and antioxidant response are lower, while lipid peroxidation is higher.

    “In patients with preeclampsia, antioxidant nutrient levels as well as antioxidant response was lower while lipid peroxidation was higher (Takagi et al, 2004;Aydin et al, 2004 andMikhail et al, 1994).”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Mikhail et al, 1994

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Authors
Mikhail, M. S., Anyaegbunam, A., Garfinkel, D., Palan, P. R., Basu, J., & Romney, S. L.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Mikhail, Magdy S.
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1994-07
Volume
171
Issue
1
Pages
150-157
ISSN
0002-9378 (ISSN-L)
OpenAlex
W2063095299
Cited by
229
References
29
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 5
FWCI
6.26
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords
preeclampsia, antioxidant nutrients, reduced ascorbic acid, vitamin C, alpha-tocopherol, vitamin E, beta-carotene, free radicals, oxidative stress, pregnancy complications
MeSH terms
Adolescent, Adult, Ascorbic Acid, Carotenoids, Female, Humans, Pilot Projects, Pre-Eclampsia, Pregnancy, Vitamin E, Case-Control Studies, beta Carotene

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