The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Quantitation of time- and frequency-resolved optical spectra for the determination of tissue oxygenation
Open accessAbstract
The recent development of near-infrared time- and frequency-resolved tissue spectroscopy techniques to probe tissue oxygenation and tissue oxygenation kinetics has led to the need for further quantitation of spectroscopic signals. In this paper, we briefly review the theory of light transport in strongly scattering media as monitored in the time and frequency domains, and use this theory to develop algorithms for quantitation of hemoglobin saturation from the photon decay rate (delta log R/delta t) obtained using time-resolved spectroscopy, and from the phase-shift (theta) obtained from frequency-resolved, phase-modulated spectroscopy. To test the relationship of these optical parameters, we studied the behavior of delta log R/delta t and theta as a function of oxygenation in model systems which mimicked the optical properties of tissue. Our results show that deoxygenation at varying hemoglobin concentrations can be monitored with the change in the photon decay kinetics, delta delta log R/delta t in the time-resolved measurements, and with the change in phase-shift, delta theta, in the frequency-resolved technique. Optical spectra of the adult human brain obtained with these two techniques show similar characteristics identified from the model systems.
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Cites
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Self-citationRefractive index of some mammalian tissues using a fiber optic cladding method
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Self-citationTime-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle
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Self-citationEffect of photosensitizer concentration in tissue on the penetration depth of photoactivating light
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Cited by
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662
Villringer, A., Planck, J., Hock, C., Schleinkofer, L., & Dirnagl, U. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90181-j · Cited by 1,119
Beyond the Visible???Imaging the Human Brain With Light
Obrig, H., & Villringer, A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200301000-00001 · Cited by 892
Spectroscopy and Imaging with Diffusing Light
Yodh, A., & Chance, B. (1995) · Physics Today · doi:10.1063/1.881445 · Cited by 800
Self-citationFLUORESCENCE MOLECULAR IMAGING
Ntziachristos, V. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095831 · Cited by 731
Metadata
- Authors
- Sevick, E. M., Chance, B., Leigh, J., Nioka, S., & Maris, M.
- Venue
- Analytical Biochemistry
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 195
- Issue
- 2
- Pages
- 330-351
- ISSN
- 0003-2697 (ISSN-L)
- OpenAlex
- W1998055482
- Cited by
- 360
- References
- 14
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Quantitation of time- and frequency-resolved optical spectra for the determination of tissue oxygenation. https://app.cochat.ai/papers/10.1016/0003-2697(91)90339-u
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- Sevick, E. M., Chance, B., Leigh, J., Nioka, S., & Maris, M. (1991). Quantitation of time- and frequency-resolved optical spectra for the determination of tissue oxygenation. Analytical Biochemistry. https://doi.org/10.1016/0003-2697(91)90339-u
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
