The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns
Open accessAbstract
In the twentieth century, NAD+ research generated multiple discoveries. Identification of the important role of NAD+ as a cofactor in cellular respiration and energy production was followed by discoveries of numerous NAD+ biosynthesis pathways. In recent years, NAD+ has been shown to play a unique role in DNA repair and protein deacetylation. As discussed in this review, there are close interactions between oxidative stress and immune activation, energy metabolism, and cell viability in neurodegenerative disorders and ageing. Profound interactions with regard to oxidative stress and NAD+ have been highlighted in the present work. This review emphasizes the pivotal role of NAD+ in the regulation of DNA repair, stress resistance, and cell death, suggesting that NAD+ synthesis through the kynurenine pathway and/or salvage pathway is an attractive target for therapeutic intervention in age-associated degenerative disorders. NAD+ precursors have been shown to slow down ageing and extend lifespan in yeasts, and protect severed axons from degeneration in animal models neurodegenerative diseases.
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“linking oxidative stress and mitochondrial dysfunction (Massudi et al., 2012).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Massudi et al., 2012
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Metadata
- Authors
- Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N.
- Affiliations
- Sydney Adventist Hospital (AU)
- UNSW Sydney (AU)
- Corresponding author
- Braidy, Nady
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2012-01
- Volume
- 17
- Issue
- 1
- Pages
- 28-46
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- PMC
- PMC6837626
- OpenAlex
- W1987514860
- Cited by
- 158
- References
- 196
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 20 · 2020: 17 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 4
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Redox Report (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of New South Wales
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- NAD+ metabolism, oxidative stress, NAD biosynthesis, kynurenine pathway, salvage pathway, DNA repair, protein deacetylation, stress tolerance, cell death, neurodegenerative diseases, aging, lifespan extension, axonal degeneration, immune activation, energy metabolism
- MeSH terms
- Aging, Animals, Cell Membrane, DNA Repair, Energy Metabolism, Enzyme Activation, Humans, Kynurenine, Mammals, NAD, Poly(ADP-ribose) Polymerases, Cell Death, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases, Sirtuins
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