Early pharmacokinetics and clinical effects of oral d-amphetamine in normal subjects
Abstract
Seven normal subjects received 0.25 mg/kg D-amphetamine orally, both after an overnight fast and again after a standard breakfast. Plasma levels, subjective and cardiovascular effects, and observer-rated activation were assessed hourly for 5 hr. Food did not affect amphetamine levels. Plasma levels peaked at 2-3 hr. Maximum cardiovascular effects generally occurred at 1 hr, whereas maximum behavioral and subjective effects occurred at 2 hr. Subjective and behavioral effects declined thereafter, in spite of substantial amphetamine levels. A separate group of 8 subjects received 0.5 mg/kg D-amphetamine orally. Plasma levels, subjective and cardiovascular effects, and activation ratings were assessed hourly for 4 hr. Maximum plasma levels were approximately twice those seen in the first group. In this case, plasma levels peaked at 3-4 hr; blood pressure and subjective and behavioral effects were all maximal at 2-3 hr and were declining by 4 hr, in spite of stable or rising plasma levels.
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The selected 90-minute wait period allowed for the therapeutic effects of amphetamine-dextroamphetamine to occur before and throughout tasks.
“The selected 90-minute wait period for this study allowed for the therapeutic effects of amphetamine–dextroamphetamine to occur before and throughout tasks (Angrist et al., 1987).”
From Effects of stimulant medication on neuropsychological functioning in college students without ADHD. (2026) · cites this paper as Angrist et al., 1987
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Effects of stimulant medication on neuropsychological functioning in college students without ADHD.
Vasko, J. M., Looby, A., Serrano, J. W., Abu-Ramadan, T. M., Miller, E. A., McGee, N., Smith, D. T., & Hartung, C. M. (2026) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000853
- Authors
- Angrist, B., Corwin, J., Bartlik, B., & Cooper, T.
- Affiliations
- United States Department of Veterans Affairs (US)
- NYU Langone Health (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Angrist, Burt
- ORCID
- Cooper, Thomas
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 22
- Issue
- 11
- Pages
- 1357-1368
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2005947884
- Cited by
- 171
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 8 · 2012: 8
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- d-amphetamine, oral administration, pharmacokinetics, plasma drug concentration, food effect on absorption, cardiovascular effects, subjective effects, behavioral activation, dose-response relationship, stimulants
- MeSH terms
- Administration, Oral, Adult, Arousal, Dextroamphetamine, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged
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