CoChat
Sign Up
Cited by 476Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men

Leyton, M·2002·Neuropsychopharmacology
DOI 10.1016/s0893-133x(02)00366-4
Open this paper in CoChat — free account

Abstract

Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using: (1) brain parametric maps to statistically generate regions of significant change; and (2) a priori identified regions of interest (ROI) manually drawn on each individual's co-registered magnetic resonance (MR) images. Compared with placebo, d-amphetamine decreased [11C]raclopride binding potential (BP) with significant effects in ventral but not dorsal striatum. Change in BP in the statistically generated cluster correlated with self-reported drug-induced 'drug wanting' (r = 0.83, p =.01) and the personality trait of Novelty Seeking-Exploratory Excitability (r = 0.79, p =.02). The same associations were seen in the manually drawn ROI in ventral striatum but not in dorsal putamen or caudate. Changes in extracellular dopamine (DA) did not correlate with mood. Mesolimbic DA might mediate interest in obtaining reward rather than reward, per se. Individual differences in amphetamine-induced DA release might be related to predispositions to drug and novelty seeking.

Integrity signals

Registry

Crossref · 10.1016/s0893-133x(02)00366-4

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Recruitment of brain regions involved in reward processing has been linked to measures of sensation seeking in humans and animals.

    “Recruitment of brain regions and systems implicated in reward-processing (e.g., ventral striatum, orbitofrontal cortex) has been linked to measures of sensation seeking in humans and animals”

    From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Leyton et al., 2002

  • Many rewards induce dopamine release as a consequence and correlate, but not the cause, of pleasure.

    “Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”

    From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002

  • Increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure.

    “Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”

    From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002

  • Dopamine surges in nucleus accumbens evoked by addictive amphetamine or by L-DOPA correlate poorly with human subjective liking ratings of the drug, but do control their subjective wanting ratings to take more of that drug.

    “Dopamine surges in nucleus accumbens evoked by addictive amphetamine or by L-DOPA correlate poorly with human subjective liking ratings of the drug - but do control their subjective wanting ratings to take more of that drug (Leyton et al., 2002; Evans et al., 2006).”

    From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002

  • In humans, dopamine levels are more highly correlated with subjective ratings of 'wanting' a reward than with pleasure ratings of that same reward.

    “In humans, studies show that dopamine levels are more highly correlated with subjective ratings of ‘wanting’ a reward than with pleasure ratings of that same reward (Leyton et al., 2002; Volkow et al., 2002).”

    From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Leyton et al., 2002

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Leyton, M.
Affiliations
McGill University (CA)
Corresponding author
Leyton, M
ORCID
Leyton, M
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2002-12
Volume
27
Issue
6
Pages
1027-1035
ISSN
0893-133X (ISSN-L)
DOI
10.1016/s0893-133x(02)00366-4
OpenAlex
W2071825212
Cited by
476
References
60
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 21 · 2022: 7 · 2021: 9 · 2020: 95 · 2019: 8 · 2018: 16 · 2017: 14 · 2016: 24 · 2015: 23 · 2014: 27 · 2013: 26 · 2012: 34
FWCI
4.53
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (36429, MOP–36429)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
amphetamine, extracellular dopamine, novelty seeking, [11C]raclopride, ventral striatum, mesolimbic dopamine system, individual differences, reward seeking, personality traits
MeSH terms
Adult, Amphetamine, Analysis of Variance, Corpus Striatum, Dopamine, Exploratory Behavior, Extracellular Space, Humans, Magnetic Resonance Imaging, Male, Tomography, Emission-Computed, Behavior, Addictive, Raclopride

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review