Cited by 221Stress Responses and CortisolAdrenal Hormones and DisordersTreatment of Major Depression

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Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression Implications for pathophysiology of DST nonsuppression

Holsboer, F., von Bardeleben, U., Wiedemann, K., Müller, O.A., Stalla, G.K.·1987·Biological Psychiatry

DOI 10.1016/0006-3223(87)90237-x

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Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
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Combined administration of human corticotropin-releasing factor and lysine vasopressin induces cortisol escape from dexamethasone suppression in healthy subjects
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Regulation of Glucocorticoid Receptors in Brain by Corticosterone Treatment of Adrenalectomized Rats
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The combined dexamethasone/corticotropin-releasing hormone stimulation test is more closely associated with features of diurnal activity of the hypothalamo—pituitary—adrenocortical system than the dexamethasone suppression test
Deuschle, M., Schweiger, U., Gotthardt, U., Weber, B., Körner, A., Schmider, J., Standhardt, H., Lammers, C., Krumm, B., & Heuser, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00276-x · Cited by 36
Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression
Baghai, T. C., Schüle, C., Zwanzger, P., Minov, C., Holme, C., Padberg, F., Bidlingmaier, M., Strasburger, C. J., & Rupprecht, R. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00060-9 · Cited by 36
“Moreover, even if depressive symptoms are resolved in an individual patient suffering from recurrent depressive episodes, a persisting or even increased cortisol hypersecretion during a combined Dex/CRH test performed after remission may serve as a predictor of an increased risk for relapse or recurrence of depression…”
Background
The Dexamethasone Suppression Test in Alzheimer’s Disease and Major Depression: Relationship to Dementia Severity, Depression, and CSF Monoamines
Molchan, S. E., Hill, J., Mellow, A. M., LAWLOR, B. A., Martínez, R. A., & Sunderland, T. (1990) · International Psychogeriatrics · doi:10.1017/s1041610290000370 · Cited by 35
Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the ‘Munich vulnerability study’
Krieg, J.-C., Lauer, C. J., Schreiber, W., Modell, S., & Holsboer, F. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00348-7 · Cited by 32
Self-citation
Response of ACTH and cortisol to human corticotropin-releasing hormone after short-term abstention from alcohol abuse
Heuser, I., von Bardeleben, U., Boll, E., & Holsboer, F. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90200-4 · Cited by 34
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Longitudinal neuroendocrine changes assessed by dexamethasone/CRH and growth hormone releasing hormone tests in psychotic depression
Owashi, T., Otsubo, T., Oshima, A., Nakagome, K., Higuchi, T., & Kamijima, K. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.011 · Cited by 33
“The combined dexamethasone (DEX)/CRH test was developed by Holsboer et al. (Holsboer et al., 1987; Holsboer-Trachsler, 1991) and the results of the dexamethasone/corticotropin releasing hormone (DEX/CRH) test are known to be more closely related to the activity of the HPA system than those of the DST (Heuser et al., 1…”
Background
Glucocorticoids as Predictors of Treatment Response in Depression
Horstmann, S., & Binder, E. B. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.586550 · Cited by 31
Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma
Paz-Filho, G., Licinio, J., & Wong, M. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000200015 · Cited by 34
Psychological coping in depressed outpatients: Association with cortisol response to the combined dexamethasone/CRH test
Hori, H., Teraishi, T., Ota, M., Hattori, K., Matsuo, J., Kinoshita, Y., Ishida, I., Nagashima, A., Koga, N., Higuchi, T., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.013 · Cited by 33
Combined dexamethasone suppression–corticotrophin-releasing hormone stimulation test in medication-free major depression and healthy volunteers
Sher, L., Oquendo, M. A., Burke, A. K., Cooper, T. B., & Mann, J. J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.049 · Cited by 30
“Some report greater cortisol and ACTH responses in depressed patients compared to healthy controls (Heuser et al., 1994a; Holsboer et al., 1987; Modell et al., 1997).”
Atrial Natriuretic Hormone Decreases Endocrine Response to a Combined Dexamethasone–Corticotropin-Releasing Hormone Test
Ströhle, A., Kellner, M. B., Holsboer, F., & Wiedemann, K. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00200-x · Cited by 29
Self-citation
Stimulation of the pituitary-adrenal axis with a low dose [Arg8]-vasopressin in depressed patients and healthy subjects
Wied, C. C. G., Westenberg, H. G. M., Koppeschaar, H. P. F., Thijssen, J. H. H., & van Ree, J. M. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90003-q · Cited by 27
Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression
Wichniak, A., Brünner, H., Ising, M., Gil, F. P., Holsboer, F., & Frieß, E. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.11.004 · Cited by 27
Self-citation
Blood mRNA expression levels of glucocorticoid receptors and FKBP5 are associated with depressive disorder and altered HPA axis
Hori, H., Yoshida, F., Ishida, I., Matsuo, J., Ogawa, S., Hattori, K., Kim, Y., & Kunugi, H. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.080 · Cited by 30
ACTH and Cortisol Response to Dex/CRH Testing in Women with and without Premenstrual Dysphoria during GnRH Agonist-Induced Hypogonadism and Ovarian Steroid Replacement
Lee, E., Nieman, L. K., Martinez, P. E., Harsh, V., Rubinow, D. R., & Schmidt, P. J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3451 · Cited by 26
The hypothalamo–pituitary–adrenal axis in major affective disorder: a review
Christensen, M. V., & Kessing, L. V. (2001) · Nordic Journal of Psychiatry · doi:10.1080/080394801317080873 · Cited by 25
“The use of the combined DEX / CRH test to predict outcome in depression In a study from 1987 the previously mentioned re ned DEX CRH test was used in a small patient sample and showed a tendency to normalization of the HPA-axis dysfunction when the depressive symptoms resolved (29).”
Method
Superoxide dismutase overexpression protects against glucocorticoid-induced depressive-like behavioral phenotypes in mice
Uchihara, Y., Tanaka, K., Asano, T., Tamura, F., & Mizushima, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.085 · Cited by 24
HPA-axis hyperactivity and mortality in psychotic depressive disorder: Preliminary findings
Coryell, W. H., Fiedorowicz, J. G., Zimmerman, M. A., & Young, E. A. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.005 · Cited by 22
“…cortisol (UFC) determination, the dexamethasone suppression test (DST) or, more recently, the combined dexamethasone/corticotropin releasing hormone test (Holsboer et al., 1995, 1987) is widely thought to be a state phenomena, an abnormality present during, but not between, depressive episodes.”
Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatients
Hori, H., Teraishi, T., Sasayama, D., Hattori, K., Hashikura, M., Higuchi, T., & Kunugi, H. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.022 · Cited by 23
Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test: a study in healthy subjects
Oshima, A., Miyano, H., Yamashita, S., Owashi, T., Suzuki, S., Sakano, Y., & Higuchi, T. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00010-3 · Cited by 22
Immune-endocrine host response to endotoxin in major depression
Vedder, H., Schreiber, W., Schuld, A., Kainz, M., Lauer, C. J., Krieg, J.-C., Holsboer, F., & Pollmächer, T. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.014 · Cited by 27
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Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain
Deng, X., Fu, J., Yang, S. T., Xu, B., Ji, Z., Guo, Q., & Ma, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.001 · Cited by 21
Magnetic resonance in patients with affective illness
McDonald, W. M., & Krishnan, K. R. R. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02195977 · Cited by 21
Persistent anxiolytic affects after chronic administration of the CRF1 receptor antagonist R121919 in rats
Gutman, D. A., Owens, M. J., Thrivikraman, K. V., & Nemeroff, C. B. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.004 · Cited by 20
“Moreover, there are a number of studies showing evidence for hypothalamic-pituitaryadrenal (HPA) axis hyperactivity in depression (Coplan et al., 1996; Gutman and Nemeroff, 2003; Holsboer et al., 1995; Holsboer et al., 1987; Nemeroff, 1999).”
A clinical study of the efficacy of a single session of individual exercise for depressive patients, assessed by the change in saliva free cortisol level
Ida, M., Ida, I., Wada, N., Sohmiya, M., Tazawa, M., & Shirakura, K. (2013) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-7-18 · Cited by 20
“The clinical manifestation of its dysfunction in depression includes basal hypercortisolemia [15], elevated cortisol secretion in the dexamethasone suppression test [16], and increased cortisol release in the combined dexamethasone suppression-corticotropine releasing hormone stimulation test [17,18].”
Background
The Role of Corticotropin-Releasing Factor in the Pathophysiology of Psychiatric Disorders
Musselman, D. L., & Nemeroff, C. B. (1993) · Psychiatric Annals · doi:10.3928/0048-5713-19931201-07 · Cited by 18
Die Neuroendokrinologie von Stress und die Pathophysiologie und Therapie von Depression und Angst
Ströhle, A. (2003) · Der Nervenarzt · doi:10.1007/s00115-002-1444-7 · Cited by 18
Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women
Wirtz, P. H., Siegrist, J., Schuhmacher, A., Hoefels, S., Maier, W., & Zobel, A. W. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.002 · Cited by 16
“Cortisol levels over the work day were shown to be elevated with OC (Hurwitz-Eller et al., 2006).”
Influential
Angiotensin II AT1 receptor antagonists inhibit the angiotensin‐CRF‐AVP axis and are potentially useful for the treatment of stress‐related and mood disorders
Saavedra, J. M., & Pavel, J. (2005) · Drug Development Research · doi:10.1002/ddr.20027 · Cited by 16
Psychoneuroendocrinology: The Scientific Basis of Clinical Practice
(2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442 · Cited by 17
The Historical Development of Immunoendocrine Concepts of Psychiatric Disorders and Their Therapy
Steinberg, H., Kirkby, K. C., & Himmerich, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226136 · Cited by 18
“In current psychiatric practice, the so-called combined dexamethasone (Dex) suppression and corticotropin-releasing hormone (CRH) test (Dex/CRH test) is frequently administered to aid diagnosis of an affective disorder [91].”
Schizotypal Personality in Healthy Adults Is Related to Blunted Cortisol Responses to the Combined Dexamethasone/ Corticotropin-Releasing Hormone Test
Hori, H., Teraishi, T., Ozeki, Y., Hattori, K., Sasayama, D., Matsuo, J., Kawamoto, Y., Kinoshita, Y., Higuchi, T., & Kunugi, H. (2011) · Neuropsychobiology · doi:10.1159/000322146 · Cited by 14
Adrenocorticotropic hormone, β-endorphin and cortisol responses to oCRH in Unipolar Depressed Patients Pretreated with Dexamethasone
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Depression: Phenomenology, Epidemiology, and Pathophysiology
Nihalani, N. D., Simionescu, M., & Dunlop, B. W. (2009) · Medical psychiatry · doi:10.3109/9781420084887.001 · Cited by 13
Modified dexamethasone suppression-corticotropin-releasing hormone stimulation test: A pilot study of young healthy volunteers and implications for alcoholism research in adolescents and young adults
Sher, L., Cooper, T. B., Mann, J., & Oquendo, M. A. (2006) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh.2006.18.1.133 · Cited by 12
Acceptance and Commitment Therapy preceded by an experimental Attention Bias Modification procedure in recurrent depression: Study protocol for a randomized controlled trial
Østergaard, T., Lundgren, T., Zettle, R., Jonassen, R., Harmer, C. J., Stiles, T. C., Landrø, N. I., & Haaland, V. Ø. (2018) · Trials · doi:10.1186/s13063-018-2515-9 · Cited by 10
“More than 75% of patients diagnosed with major depressive disorder (MDD) experience more than one episode, often relapsing within 2 years of recovery [4].”
Influential
Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients
Lamego, M. K., Moura, A. D. S., Paes, F., Rocha, N., Filho, A. S. S., Lattari, E., Rimes, R., Manochio, J., Budde, H., Wegner, M., et al. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666151111125402 · Cited by 11
Extent of cortisol suppression at baseline predicts improvement in HPA axis function during antidepressant treatment
Scherf‐Clavel, M., Wurst, C., Nitschke, F., Stonawski, S., Burschka, C., Friess, L., Unterecker, S., Hommers, L. G., Deckert, J., Domschke, K., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104590 · Cited by 11
Salivary Cortisol Awakening Response as a Predictor for Depression Severity in Adult Patients with a Major Depressive Episode Performing a Daily Exercise Program
Refsgaard, E., Schmedes, A., & Martiny, K. (2022) · Neuropsychobiology · doi:10.1159/000521234 · Cited by 11
Pituitary and Adrenal Changes in Depression
Krishnan, K. (1993) · Psychiatric Annals · doi:10.3928/0048-5713-19931201-06 · Cited by 11
Methodological aspects of hCRF-stimulated ACTH and cortisol secretion in healthy subjects
Schreiber, W., Krieg, J. C., Bossert, S., Junker, M., Rauschhuber, R., Stalla, G. K., Müller, O. A., & Berger, T. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90034-0 · Cited by 10
Self-citation
Relationships of DEX/CRH and GHRH test results to the outcome of depression – Preliminary results suggest the GHRH test may predict relapse after discharge
Owashi, T., Otsubo, T., Oshima, A., Nakagome, K., Higuchi, T., & Kamijima, K. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.01.006 · Cited by 9
“The DEX/CRH test was performed as described in detail elsewhere (Heuser et al., 1994a; Holsboer et al., 1987; Zobel et al., 2001): 1.”
Method
The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression
Guerrieri, G. M., Dor, R. R. B., Li, X., Wei, S.-M., Martinez, P. E., Neiman, L. K., Rubinow, D. R., & Schmidt, P. J. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab407 · Cited by 9
The effect of repeated human corticotropin-releasing hormone administration on dexamethasone-suppressed pituitary—adrenocortical activity in healthy subjects
Wiedemann, K., & Holsboer, F. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00434-9 · Cited by 9
Self-citation
Precision Psychiatry Approach to Treat Depression and Anxiety Targeting the Stress Hormone System – V1b-antagonists as a Case in Point
Holsboer, F., & Ising, M. (2024) · Pharmacopsychiatry · doi:10.1055/a-2372-3549 · Cited by 8
Self-citation
Clinical aspects of the link between diabetes and depression
Nagy, G., Rosta, K., Szémán, B., Sasvári‐Székely, M., & Somogyi, A. (2011) · Orvosi Hetilap · doi:10.1556/oh.2011.29070 · Cited by 8
Contingent negative variation and Dex-CRH test in patients with major depression
Hemmeter, U., Heimberg, D. R., Naber, G., Hobi, V., & Holsboer‐Trachsler, E. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00020-0 · Cited by 8
Amitriptyline Metabolism in Elderly Depressed Patients and Normal Controls in Relation to Hypothalamic-Pituitary-Adrenal System Function
Schmider, J., Deuschle, M., Schweiger, U., Kørner, A., Gotthardt, U., & Heuser, I. J. E. (1995) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199508000-00003 · Cited by 7
HIGH-DOSE NALOXONE (1.0 MG/KG): PSYCHOLOGICAL AND ENDOCRINE EFFECTS IN NORMAL MALE SUBJECTS PRETREATED WITH ONE MILLIGRAM OF DEXAMETHASONE
Martín-del-Campo, A., Cortés-Sotres, J., Herrera-Ferrá, K., & Ulloa‐Aguirre, A. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00002-x · Cited by 7
Chapter 13. Psychiatric Effects of Exogenous Anabolic-Androgenic Steroids
Pope, H. G., & Katz, D. L. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg13 · Cited by 7
Lower cerebrospinal fluid CRH concentration in chronic schizophrenia with negative symptoms
Ishiwata, S., Hattori, K., Hidese, S., Sasayama, D., Miyakawa, T., Matsumura, R., Yokota, Y., Yoshida, S., & Kunugi, H. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.03.010 · Cited by 6
Hypothalamic-Pituitary-Adrenal Axis Hyperactivity and Brain Differences in Healthy Women
Ota, M., Hori, H., Sato, N., Sasayama, D., Hattori, K., Teraishi, T., Obu, S., Nakata, Y., & Kunugi, H. (2013) · Neuropsychobiology · doi:10.1159/000355298 · Cited by 6
Experimental Protocols for the Study of Stress in Animals and Humans
Gambarana, C. (2006) · Humana Press eBooks · doi:10.1385/1-59259-952-4:021 · Cited by 6
Depression and effects of antidepressant drugs on the stress systems
(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80059-8 · Cited by 6
The hypothalamic-pituitary-adrenal axis and genetic variants affecting its reactivity
Chistyakova, N. V., & Savostyanov, K. V. (2011) · Russian Journal of Genetics · doi:10.1134/s1022795411080035 · Cited by 5
“The dexamethasone test is also accompa nied by the estimation of the CRH level, and the com bined procedure is used as a pharmacological test of HPA axis activity [32].”
Method
Neuroendocrine Alterations in Major Depressive Disorder
Ali, F., & Nemeroff, C. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-58131-8.00005-7 · Cited by 5
A unifying hypothesis of Alzheimer's disease. II. Pathophysiological processes
Heininger, K. (1999) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199912)14:8 · Cited by 27
The dexamethasone-hCRH stimulation test and cognitive performance during antidepressive treatment with trimipramine
Holsboer‐Trachsler, E., Hemmeter, U., Stohler, R., Hatzinger, M., Gerhard, U., & Hobi, V. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90552-6 · Cited by 5
Biologischer Hintergrund
Matussek, N., & Holsboer, F. (1987) · Springer eBooks · doi:10.1007/978-3-642-71819-9_8 · Cited by 5
Self-citation
The Interacting Neuroendocrine Network in Stress-Inducing Mood Disorders
Leff, P., Hernández, M. E., Becerril‐Villanueva, E., Martinez, C. B. D. R., Téllez-Santillán, C., Pérez-Tapia, M., Salazar, A., Antón, B., Berlanga, C., & Pavón, L. (2010) · The Open Neuroendocrinology Journal · doi:10.2174/1876528901003010180 · Cited by 5
“An altered test using the combined DEX/CRH challenge test, has been recently developed and used to assess the functioning of HPA axis through the stimulation by CRH, and inhibited through DEX administration [43].”
Method
Tolerability of the dexamethasone–corticotropin releasing hormone test in major depressive disorder
Dunlop, B. W., Betancourt, Y., Binder, E. B., Heim, C. C., Holsboer, F., Ising, M., McKenzie, M., Mletzko, T., Pfister, H., Nemeroff, C. B., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.020 · Cited by 4
“One promising test for predicting treatment response in MDD is the dexamethasonecorticortopin releasing hormone (Dex-CRH) test (Holsboer et al., 1987).”
Self-citation
Determination of dexamethasone in saliva
Thijssen, J. H. H., Wied, C. C. G., Heeswijk, G. M. V., & Veeman, W. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.8.1238 · Cited by 4
Neuroendocrinology
Nemeroff, C. B., & Neigh, G. N. (2012) · doi:10.1093/med/9780199696758.003.0020 · Cited by 4
Genetics of Endocrine-Behavior Interactions
Müller, M. B., Keck, M. E., Steckler, T., & Holsboer, F. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50093-7 · Cited by 4
Self-citation
Cortisol Response to Corticotropin Releasing Hormone in Dexamethasone-Pretreated Patients with Depression
von Bardeleben, U., & Holsboer, F. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3_22 · Cited by 4
Self-citation
Corticosteroid Hormones in Stress and Anxiety – Role of Receptor Variants and Environmental Inputs
DeRijk, R. H., Kitraki, E., & de Kloet, E. R. (2009) · doi:10.1002/9783527628346.ch7 · Cited by 4
Chapter 15. Psychiatric and Behavioral Manifestations of Hyperthyroidism and Hypothyroidism
Bauer, M., Szuba, M. P., & Whybrow, P. C. (2003) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550442.lg15 · Cited by 4
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“did a study on the repeated administration of the combined DEX/CRH test which had been developed before by Holsboer et al. [”
Background
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Self-citation

Authors: Holsboer, F., von Bardeleben, U., Wiedemann, K., Müller, O. A., & Stalla, G. K.
Affiliations: Johannes Gutenberg University Mainz (DE)
Ludwig-Maximilians-Universität München (DE)
Corresponding author: Holsboer, F.
ORCID: Wiedemann, K.
Müller, O.A.
Stalla, G.K.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1987-02
Volume: 22
Issue: 2
Pages: 228-234
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(87)90237-x
OpenAlex: W1979581115
Cited by: 221
References: 13
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 7 · 2012: 11
FWCI: 2.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: corticotropin-releasing factor, dexamethasone suppression test, depression, hypothalamic-pituitary-adrenal axis, glucocorticoid feedback, serial assessment, depression pathophysiology
MeSH terms: Adrenocorticotropic Hormone, Adult, Bipolar Disorder, Corticotropin-Releasing Hormone, Depressive Disorder, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System

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Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression Implications for pathophysiology of DST nonsuppression

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