Oxytocin-induced anxiogenic behavior in juvenile male rats
Open accessAbstract
Oxytocin (OT) is considered beneficial to mental health owing to its anxiolytic, prosocial, and anti-stress effects; however, the adverse effects of OT have been controversial, such as its potentially anxiogenic actions. Although OT influences drug abuse and reciprocally affects vulnerability to drug use, the relationship between OT's anxiogenic working and nicotine preference intake has not been clearly defined. To clarify this issue, the effect of acute peripheral administration of OT on anxiety and nicotine preference was investigated in juvenile male rats. Anxiogenic behaviors were noticeably increased in OT-administrated rats, with an increase in serum corticosterone levels. Moreover, increased anxiety-like behaviors and corticosterone levels were observed in the OT analog carbetocin-injected rats. In the nicotine preference test, the rats' aversive responses to initial nicotine choice and preference were not significantly different between saline-injected and OT-injected rats. However, when administered with OT, there was a significant negative correlation between anxiety-like behavior and low-dose nicotine consumption. Collectively, these results provide evidence that acute OT exposure could induce anxiogenic behavior with corticosterone augmentation, contributing to the attenuation of nicotine preference. This suggests that both aspects of OT, as well as their benefits and drawbacks, should be considered.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxytocin is a critical modulator of fear and anxiety and in the vast majority of cases elicits anxiolytic effects.
“Oxytocin, on its side, has been widely demonstrated to be a critical modulator of fear and anxiety (Jurek and Neumann, 2018), which in the vast majority of cases, elicits anxiolytic effects (see Jang et al. (2021); Chun et al. (2022)).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Jang et al. (2021)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans
De Dreu, C. K. W., Greer, L. L., Handgraaf, M. J. J., Shalvi, S., Van Kleef, G. A., Baas, M., Ten Velden, F. S., Van Dijk, E., & Feith, S. W. W. (2010) · Science · doi:10.1126/science.1189047 · Cited by 1,148 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · cited 1× · see citing works
“Sex differences in the OT system are not always uniform, often showing higher OT expression in females than in males, but higher OTR expression in males than in females (Dumais and Veenema 2016).”
BackgroundMens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
Declerck, C. H., Boone, C., & Kiyonari, T. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.006 · Cited by 331 · see citing works
Frahm, S., Ślimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.-F., Tsetlin, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.013 · Cited by 283 · see citing works
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268 · see citing works
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242 · see citing works
Effects of oxytocin on recollections of maternal care and closeness
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N., & Lydon, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012669107 · Cited by 235 · cited 1× · see citing works
“Consistent with our data, intranasal administration of OT increases the recollection of aversive events (Bartz et al. 2010) and startle responses to stressful stimuli (Grillon et al. 2013).”
BackgroundOxytocin increases anxiety to unpredictable threat
Grillon, C., Krimsky, M., Charney, D. R., Vytal, K., Ernst, M., & Cornwell, B. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.156 · Cited by 192 · see citing works
Peters, S., Slattery, D. A., Uschold‐Schmidt, N., Reber, S. O., & Neumann, I. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.021 · Cited by 180 · see citing works
Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats
Petersson, M., Hulting, A., & Uvnäs‐Moberg, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00159-7 · Cited by 156 · see citing works
Oxytocin—its role in male reproduction and new potential therapeutic uses
Thackare, H., Nicholson, H. D., & Whittington, K. (2006) · Human Reproduction Update · doi:10.1093/humupd/dmk002 · Cited by 146 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Zanos, P., Georgiou, P., Wright, S. R., Hourani, S. M., Kitchen, I., Winsky-Sommerer, R., & Bailey, A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.285 · Cited by 133 · see citing works
Oxytocin indexes relational distress following interpersonal harms in women
Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J., & McCabe, P. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.004 · Cited by 116 · see citing works
Oxytocin Facilitates Pavlovian Fear Learning in Males
Eckstein, M., Scheele, D., Patin, A., Preckel, K., Becker, B., Walter, A., Domschke, K., Grinevich, V., Maier, W., & Hurlemann, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.245 · Cited by 87 · see citing works
Sobota, R., Mihara, T., Forrest, A., Featherstone, R. E., & Siegel, S. J. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000074 · Cited by 80 · see citing works
Passoni, I. P., Leonzino, M., Gigliucci, V., Chini, B., & Busnelli, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12363 · Cited by 76 · see citing works
Behavioral stress decreases plasma oxytocin concentrations in primates.
Kalin, N., Gibbs, D., Barksdale, C., Shelton, S., & Carnes, M. (1985) · Life Science · doi:10.1016/0024-3205(85)90272-3 · Cited by 50 · see citing works
Chen, H., Sharp, B. M., Matta, S. G., & Wu, Q. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.149 · Cited by 47 · see citing works
Effects of oxytocin on nicotine withdrawal in rats
Manbeck, K. E., Shelley, D., Schmidt, C. E., & Harris, A. C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.002 · Cited by 45 · see citing works
Oxytocinergic regulation of endogenous as well as drug-induced mood
Broadbear, J. H., Kabel, D., Tracy, L. M., & Mak, P. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.002 · Cited by 30 · see citing works
Oxytocin and vasopressin modulate risk-taking
Patel, N., Grillon, C., Pavletic, N., Rosen, D., Pine, D. S., & Ernst, M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.018 · Cited by 29 · see citing works
Sakamoto, T., Sugimoto, S., & Uekita, T. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112701 · Cited by 25 · see citing works
Oxytocin attenuates aversive response to nicotine and anxiety-like behavior in adolescent rats
Lee, H., Jang, M., & Noh, J. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.11.007 · Cited by 21 · see citing works
Self-citationKritman, M., Lahoud, N., & Maroun, M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.04.001 · Cited by 21 · see citing works
Jung, T., & Noh, J. (2021) · Animal Cells and Systems · doi:10.1080/19768354.2021.1902854 · Cited by 18 · see citing works
Self-citationLee, Y., Kang, H., Jin, C., Zhang, Y., Kim, Y., & Han, K. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1595142 · Cited by 13 · see citing works
Park, H.-J., Shim, H. S., Park, S., & Shim, I. (2020) · Animal Cells and Systems · doi:10.1080/19768354.2020.1808063 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hernández-Mondragón, J. C., Hernández-Hernández, D. A., Crespo-Ramírez, M., Prospero-García, O., Rocha-Arrieta, L., Fuxe, K., Borroto-Escuela, D. O., & Perez de la Mora, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1251922 · Cited by 17 · see citing works
- Authors
- Jang, M., Jung, T., Kang, M., Kim, J., & Noh, J.
- Affiliations
- Dankook University (KR)
- Korea Brain Research Institute (KR)
- Corresponding author
- Noh, Jihyun
- Venue
- Animal Cells and Systems
- Publisher
- Informa UK Limited
- Published
- 2021-10-31
- Volume
- 25
- Issue
- 6
- Pages
- 369-376
- ISSN
- 1976-8354 (ISSN-L)
- 2151-2485
- PMC
- PMC8765244
- OpenAlex
- W3209273604
- Cited by
- 8
- References
- 30
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 4
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animal Cells and Systems (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea
- Korea government (NRF-2019R1A2C1002963)
- Brain
- Ministry of Science
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, anxiogenic behavior, anxiety-like behavior, corticosterone, nicotine preference, carbetocin, young rats, nicotine use, drug abuse vulnerability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
