Administration of 1,25-dihydroxyvitamin D3 results in the elevation of hippocampal seizure threshold levels in rats
Abstract
Electrical stimulation of the dorsal hippocampal formation of the rat was employed to determine the effect of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the hormonal form of vitamin D, on induced seizure thresholds. Stereotaxic injection of 100 micrograms or 50 micrograms 1,25-dihydroxyvitamin D3 in 2 microliter propylene glycol into the hippocampus resulted in a significant elevation in seizure threshold in all animals treated. 1,25-dihydroxyvitamin D3-induced increases were noted within 5-10 min and lasted at least 120-180 min after injection when the experiments were terminated. Intravenous injection of 1,25-(OH)2D3 also resulted in a significant elevation of seizure threshold; however, the increase was transient, lasting only 30 min. This effect was specific since 200 micrograms vitamin D3 or 200 micrograms 25-hydroxyvitamin D3 (25-(OH)D3), injected into the hippocampus, had no effect on seizure threshold levels. This investigation represents the first direct demonstration of a role for 1,25-(OH)2D3 in the regulation of seizure activity and suggests, along with the previously demonstrated presence of immunoreactive vitamin D-dependent calcium binding protein and receptors for 1,25-dihydroxyvitamin D3 in the brain, that the vitamin D endocrine system may play a significant role in the physiological mechanisms underlying convulsive disorders.
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Vitamin D and its analogues increase seizure threshold in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [196]
Vitamin D and its analogues decrease the severity of seizures in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [196]
Vitamin D and its analogues potentiate anticonvulsant activity of antiepileptic drugs in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [196]
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- Authors
- Siegel, A., Malkowitz, L., Moskovits, M. J., & Christakos, S.
- Affiliations
- Rutgers New Jersey Medical School (US)
- Corresponding author
- Christakos, Sylvia
- ORCID
- Christakos, Sylvia
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1984-04
- Volume
- 298
- Issue
- 1
- Pages
- 125-129
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2081968535
- Cited by
- 78
- References
- 27
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Keywords
- 1,25-dihydroxyvitamin D3, vitamin D, seizure threshold, hippocampus, epilepsy, convulsive disorders, vitamin D receptor, calcium-binding proteins, intracerebral injection, intravenous administration, vitamin D3, 25-hydroxyvitamin D3
- MeSH terms
- Animals, Calcitriol, Electric Stimulation, Electroencephalography, Hippocampus, Male, Rats, Inbred Strains, Seizures, Rats
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